Professor of Microbiology
Phone:(206) 732-6135, (206) 604-1690
Office Location: 258B Rosen Building
Campus Box: 358070
Dr. Katze is Professor of Microbiology and Associate Director and Core Staff Scientist at the Washington National Primate Research Center. He received his Ph.D. from Hahnemann Medic1al College and was a postdoctoral fellow at the University of Uppsala in Sweden as part of a fellowship with the European Molecular Biology Organization. Prior to joining the faculty at the University of Washington, Dr. Katze conducted research in molecular biology and virology at the Memorial Sloan-Kettering Cancer Center in New York City.
Research in the Katze lab is focused on the use of systems biology (high-throughput and computational) approaches to define and model virus-host interactions, innate immune signaling, and the varied strategies used by viruses to evade cellular defense mechanisms. The lab studies a wide range of viral pathogens, including pandemic, seasonal, and avian influenza viruses, SARS and MERS coronaviruses, Ebola virus, hepatitis C virus, and human and simian immunodeficiency viruses. In addition, the group is spearheading efforts to develop genomic resources for nonhuman primate, ferret, and Syrian hamster models of human virus infection..
In July 2013, the lab was awarded a $15 million contract to serve as the NIAID Nonhuman Primate Core Functional Genomics Laboratory for AIDS Vaccine Research and Development. This is a national resource for measuring vaccine responses at the molecular level and for discovering markers that may be prognostic in assessing if a vaccination will protect against HIV.
Chang, S.T., M.J. Thomas, P. Sova, R.R. Green, R.E., Palermo, and M.G. Katze. 2013. Next-generation sequencing of small RNAs from HIV-infected cells identifies phased microRNA expression patterns and candidate novel microRNAs differentially expressed upon infection. mBio. 4(1):e00549-12.
Josset, L., V.D. Menachery, L.E. Gralinski, S. Agnihothram, P. Sova, V.S. Carter, B.L. Yount, R.L. Graham, R.S. Baric, and M.G. Katze. 2013. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio 4(3):e00165-13.
Law, G.L., M.J. Korth, A.G. Benecke, and M.G. Katze. 2013. Systems virology: host-directed approaches to viral pathogenesis and drug targeting. Nature Rev. Microbiol. 11:455-466.
Pipes, L., S. Li, M. Bozinoski, X. Peng, S. Kelly, J.M. Weiss, J. Thierry-Mieg, D. Thierry-Mieg, P. Zumbo, R. Chen, R. Palermo, G.P. Schroth, C.E. Mason, and M.G. Katze. 2013. The Nonhuman Primate Reference Transcriptome Resource (NHPRTR) for comparative functional genomics. Nucleic Acid Res. 41:D906-914.
Josset, L., J.A. Belser, M. J. Pantin-Jackwood, J.H. Chang, S.T. Chang, S.E. Belisle, T.M. Tumpey, and M.G. Katze. 2012. Implication of inflammatory macrophages, nuclear receptors and interferon regulatory factors in increased virulence of pandemic 2009 H1N1 influenza A virus after host adaptation. J. Virol. 86:7192-7206.
Tisoncik, J.R., M.J. Korth, C.P. Simmons, J. Farrar, T.R. Martin, and M.G. Katze. 2012. Into the eye of the cytokine storm. Microbiol. Mol. Bio. Rev. 76:16-32.