Michael Katze
Professor of Microbiology

Website
COS Profile
Email: honey@u.washington.edu
Phone:(206) 221-2848
Office Location: 258B Rosen Building
Campus Box: 358070

Research:

Dr. Katze is Professor of Microbiology and Associate Director and Core Staff Scientist at the Washington National Primate Research Center. He received his Ph.D. from Hahnemann Medical College and was a postdoctoral fellow at the University of Uppsala in Sweden as part of a fellowship with the European Molecular Biology Organization. Prior to joining the faculty at the University of Washington, Dr. Katze conducted research in molecular biology and virology at the Memorial Sloan-Kettering Cancer Center in New York City.

Research in the Katze lab is focused on virus-host interactions. In particular, the lab studies the varied and complex mechanisms used by viruses to avoid the interferon-mediated antiviral response and the clever ways by which viruses hijack the cellular protein synthesizing machinery. The lab is a leader in using the technologies of functional genomics, including DNA microarrays and proteomics, to study the wide constellation of changes in cellular gene expression and protein production that occur in response to virus infection. These technologies are used to analyze a broad range of experimental systems, including those focused on hepatitis C virus (HCV), influenza virus, Ebola virus, and simian immunodeficiency virus (SIV). Additional studies are aimed at profiling patterns of gene expression in serial liver biopsies obtained from patients who have undergone liver transplantation due to HCV-associated liver disease.

The lab is also working to develop a nationwide resource to facilitate the use of genomic technologies in nonhuman primate research, with particular emphasis on the rhesus macaque. The aim in establishing this resource is to provide the research community with the tools necessary to gain insight into the evolutionary relationship between human and macaque genomes and to better use the macaque as a model for reproduction, development, infection, and disease. Current work is focused on the construction of rhesus macaque cDNA libraries, large-scale expressed sequence tag (EST) sequencing of library clones, and the construction of oligonucleotide microarrays.

Selected Publications:

Katze, M. G., J. L. Fornek, R. E. Palermo, K. A. Walters, and M. J. Korth. 2008. Innate immune modulation by RNA viruses: emerging insights from functional genomics. Nat. Rev. Immunol. 8:644-654.


Chan, E. Y., W. J. Qian, D. L. Diamond, T. Liu, M. A. Gritsenko, M. E. Monroe, D. G. Camp, II, R. D. Smith, and M. G. Katze. 2007. Quantitative analysis of human immunodeficiency virus type 1-infected CD4+ cell proteome: dysregulated cell cycle progression and nuclear transport coincide with robust virus production. J. Virol. 81:7571-7583.


Gibbs, R. A., J. Rogers, M. G. Katze, et al. 2007. Evolutionary and biomedical insights from the rhesus macaque genome. Science 316:222-234.


Kobasa, D., S. M. Jones, K. Shinya, J. C. Kash, J. Copps, H. Ebihara, Y. Hatta, J. H. Kim, P. Halfmann, M. Hatta, F. Feldmann, J. B. Alimonti, L. Fernando, Y. Li, M. G. Katze, H. Feldmann, and Y. Kawaoka. 2007. Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature 445:319-323.


Tan, S. L., G. Ganji, B. Paeper, S. Proll, and M. G. Katze. 2007. Systems biology and the host response to viral infection. Nat. Biotechnol. 25:1383-1389.


Kash, J. C., T. M. Tumpey, S. C. Proll, V. Carter, O. Perwitasari, M. J. Thomas, C. F. Basler, P. Palese, J. K. Taubenberger, A. Garcia-Sastre, D. E. Swayne, and M. G. Katze. 2006. Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus. Nature 443:578-581.