Professor of Microbiology and of Chemical Engineering
University of Washington Vice Provost for Research
Phone:(206) 616-5282, (206) 616-0804
Office Location: 440 R&T Building, G80 Gerberding
Campus Box: 355014, 351202
In addition to her appointment in Microbiology, Dr. Mary Lidstrom holds the Frank Jungers Chair of Chemical Engineering. She received a B.S. in microbiology from Oregon State University, and a M.Sc. and Ph.D. in bacteriology from the University of Wisconsin. Dr. Lidstrom conducted postdoctoral work as a Leverhulme Fellow in Microbiology at the University of Sheffield, and has held academic appointments in microbiology at the University of Washington, in the Center for Great Lakes Studies in Milwaukee, Wisconsin and in Environmental Engineering Science at the California Institute of Technology. She serves on the advisory boards of the DOE Energy Biosciences Council, the Environmental Sciences Division of the Oak Ridge National Laboratory, and is a member of the National Academies of Sciences. She is also the Vice Provost for Research at the University of Washington.
Research in Dr. Lidstrom's laboratory is focused on molecular and metabolic manipulations of methylotrophic bacteria, which are capable of growth on methane, methanol, and methylated amines. The long-term goal of this research is to develop environmentally sound and economically viable alternatives to current chemical production and cleanup strategies. Genetic, physiological and metabolic modeling approaches are used to understand key metabolic pathways in these bacteria, with the goal of directed manipulation of key metabolic pathways and enzymes. The laboratory's recent discovery that methylotrophic bacteria contain a metabolic pathway previously thought to be found only in methanogenic archaea has generated a new research thrust focused on evolution of C1 metabolic pathways across the bacterial/archaeal boundaries. These studies are now being augmented by genomic approaches, including proteomics and expression microarrays. In addition, the laboratory is involved with an interdisciplinary center, the Microscale Life Sciences Center, with a focus on studying metabolism in single cells.
Chistoserdova, L., A. Lapidus and M.E. Lidstrom. 2003. Methylotrophy in Methylobacterium extorquens AM1 from a Genomic Point of View, J. Bacteriol., 185(10): 2980-7.
Lidstrom, M.E. Meldrum, D.R. 2003. Life-on-a-Chip. Nature Reviews Microbiology 1, 158-164.
Korotkova N., M. E. Lidstrom, and L. Chistoserdova. Identification of Genes Involved in the Glyoxylate regeneration cycle in Methylobacterium extorquens AM1 including two new genes, meaC and meaD. J. Bacteriol. 2005. 187(4): 1523-1526.
Chistoserdova, L., J.A. Vorholt, and M.E. Lidstrom. A genomic view of methane oxidation by aerobic bacteria and anaerobic archaea. Genome Biol. 2005. 6(2): Art. No. 208.
Marx, C.J., S. Van Dien, and M.E. Lidstrom. 2005. Flux analysis uncovers key role of functional redundancy in formaldehyde metabolism. PloS Biology 2005. 3(2): 244-253.
Miller J.A., M.G. Kalyuzhnaya, E. Noyes, J.C. Lara, M.E. Lidstrom, and L. Chistoserdova. Labrys methylaminophilus Gen. Nov., Sp. Nov., a new facultatively methylotrophic bacterium from a freshwater lake sediment. Internat. J. Syst. Evol. Microbiol. 2005. Accepted January 4.