Research:
John Mittler received his B.A. in biophysics and applied mathematics from the University of California at Berkeley and his Ph.D. in biological sciences from the University of California at Irvine with Dr. Richard Lenski. John also did postdoctoral research at Emory University with Dr. Bruce Levin and at Los Alamos National Laboratory with Dr. Alan Perelson.
Dr. Mittler’s laboratory specializes in the population biology of microorganisms. Examples of questions addressed in his laboratory include: (1) How can therapy regimens be optimized to reduce the probability that HIV-1 will evolve resistance to anti-retroviral drugs? (2) Can we create realistic mathematical models for the interactions between HIV-1 and the immune system? (3) How can compartments and reservoirs for viral and bacterial infections be identified and targeted? (4) How can cytokines and other immunodulatory agents be employed to reduce HIV-1 replication? (5) Can we create models to account for the ordered construction and evolution of the flagellum in Salmonella typhimurium?
Selected Publications:
Wang, K., Jenwitheesuk, E., Samudrala, S., and Mittler J. E. 2004. Simple linear model provides highly accurate genotypic predictions of HIV-1 drug resistance. Antiviral Therapy 9: 343-352.
Wang, K., Samudrala, R., and Mittler, J. E. 2004. Antivirogram or PhenoSense: a comparison of their reproducibility and an analysis of their correlation. Antiviral Therapy 9: 703–712.
Mittler, J. 2005. Within-host dynamics and treatment of HIV-1 infection: Unanswered Questions and Challenges for Computational Biologists. Chapter 16 in Deterministic and Stochastic Models for AIDS Epidemics and HIV Infection with Interventions. Eds. Wu, H. and Tan W-Y. World Scientific Publisher.
Liu, Y., Mullins, J. I., and Mittler, J. E. 2006. Waiting Times for the Appearance of Cytotoxic T-lymphocyte Escape Mutants in Chronic HIV-1 infection. Virology 347:140-146.
Price, M. V. and Mittler, J. E. 2006. Cachers, scavengers, and thieves: a novel mechanism for desert rodent coexistence. American Naturalist 168:194–206.
Wang, K., Mittler, J. E., and Samudrala R. 2006. Comment on evidence for positive epistasis in HIV-1. Science 312:848.
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