Associate Professor of Microbiology
Office Location: 322 Rosen Building
Campus Box: 358070
John Mittler received his B.A. in biophysics and applied mathematics from the University of California at Berkeley. John got his Ph.D. from the University of California at Irvine where he studied bacterial evolution with Dr. Richard Lenski. After getting his Ph.D., he did postdoctoral research on bacteria-phage interactions with Bruce Levin at Emory University and HIV-1 dynamics with Alan Perelson at Los Alamos National Laboratory.
Dr. Mittler’s laboratory focuses on the population biology microorganisms. Owing to their rapid generation times, large population sizes, and ease of culture, microbes are ideally suited for testing ecological and evolutionary theories. The laboratory takes particular delight in projects that make good use of mathematical or computational models of population dynamics. Examples of questions addressed in our laboratory include: (1) How rapidly do bacteria and viruses replicate within a host? (2) How can combination antiretroviral therapy regimens be optimized to reduce the probability that viruses will evolve drug resistance? (3) What are the ecological forces that prevent cheaters from exploiting bacteria that release “public goods”, such as antibiotics and proteases, into the growth medium?
Curlin M., Iyer, S., and Mittler, J. E. 2007. Optimal timing and duration of induction therapy for HIV-1 Infection. PLoS Computational Biology 3:e133.
Gill, W. P, Harik, N. S., Whiddon, M. R., Mittler, J. E., and Sherman D. R. 2009. A replication clock for Mycobacterium tuberculosis. Nature Medicine 15:211-214.
Haft, R. J. F., Mittler J. E., and Traxler B. 2009. Competition favours reduced cost of plasmids to host bacteria. ISME Journal 3:761-769.
Heath L., Fox, A., Mc Clure J., Diem, K., van ‘t Wout A., Zhou H., Park D., Schouten J., Twigg, J. H., Corey L., Mullins J. I., and Mittler, J. E. 2009. Evidence for limited genetic compartmentalization of HIV-1 between lung and blood. PLoS ONE 4:e6949.
Lim, H-C, Curlin M.E., and Mittler J.E. 2011. HIV Therapy Simulator: a graphical user interface for comparing the effectiveness of novel therapy regimens. Bioinformatics 27: 3065-3066.