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James Mullins
Professor of Microbiology and Medicine
Adjunct Professor of Laboratory Medicine

Website
Email: jmullins@u.washington.edu
Phone:(206) 732-6163
Office Location: 358B Rosen Building
Campus Box: 358070

 

 

 

 

 

Research:

Dr. Mullins obtained his Ph.D. in Cell Biology and Biochemistry from the University of Minnesota in 1978. He did postdoctoral work at the California Institute of Technology before becoming Assistant then Associate Professor at the Harvard University School of Public Health. In 1989 he moved to Stanford University as Professor and was Chairman of the Department of Microbiology and Immunology from 1991 until his move to the University of Washington in 1994 where he is on the faculty of the Departments of Microbiology, Medicine, and Laboratory Medicine. He served as Chair of Microbiology from 1997-2002. Dr. Mullins has published more than 360 original articles, reviews and book chapters on the topics of retroviruses and AIDS and has delivered more than 320 invited seminars and symposium presentations.

The Mullins lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship in an effort to assist the fight to stop the AIDS pandemic. They use a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS, with the intention of applying this information to the development of more effective therapies and vaccines. These techniques include virology, molecular biological and statistical analysis of nucleotide sequences.

Selected Publications:

1 Wagner, T.A., Mckernan, J.L., Tobin, N.H., Tapia, K.A., Mullins, J.I., and Frenkel, L.M., An Increasing Proportion of Monotypic HIV-1 DNA Sequences During Antiretroviral Treatment Suggests Proliferation of HIV-Infected Cells, J Virol 87 (3), 1770-8 (2013) PMC3554159

2 Shankarappa, R. and Mullins, J.I., Viral Population Structures Inferred Using Heteroduplex Mobility and DNA Sequence Analyses, J Virol Methods 194 (1-2), 169-77 (2013)

3 Rolland, M., Manocheewa, S., Swain, J.V., Lanxon-Cookson, E.C., Kim, M., Westfall, D.H., Larsen, B.B., Gilbert, P.B., and Mullins, J.I., HIV-1 Conserved-Element Vaccines: Relationship between Sequence Conservation and Replicative Capacity, J Virol 87 (10), 5461-7 (2013) PMC3648173

4 Raugi, D.N., Smith, R.A., Ba, S., Toure, M., Traore, F., Sall, F., Pan, C., Blankenship, L., Montano, A., Olson, J., Dia Badiane, N.M., Mullins, J.I., Kiviat, N.B., Hawes, S.E., Sow, P.S., Gottlieb, G.S., and For the University of Washington-Dakar, H.I.V.S.G., Complex Patterns of Protease Inhibitor Resistance among Antiretroviral Treatment-Experienced HIV-2 Patients from Senegal: Implications for Second-Line Therapy, Antimicrob Agents Chemother 57 (6), 2751-60 (2013) PMC3716120

5 Nakamura, K.J., Cerini, C., Sobrera, E.R., Heath, L., Sinkala, M., Kankasa, C., Thea, D.M., Mullins, J.I., Kuhn, L., and Aldrovandi, G.M., Coverage of Primary Mother-to-Child HIV Transmission Isolates by Second-Generation Broadly Neutralizing Antibodies, AIDS 27 (3), 337-46 (2013)

6 Mclaren, P.J., Coulonges, C., Ripke, S., Van Den Berg, L., Buchbinder, S., Carrington, M., Cossarizza, A., Dalmau, J., Deeks, S.G., Delaneau, O., De Luca, A., Goedert, J.J., Haas, D., Herbeck, J.T., Kathiresan, S., Kirk, G.D., Lambotte, O., Luo, M., Mallal, S., Van Manen, D., Martinez-Picado, J., Meyer, L., Miro, J.M., Mullins, J.I., Obel, N., O'brien, S.J., Pereyra, F., Plummer, F.A., Poli, G., Qi, Y., Rucart, P., Sandhu, M.S., Shea, P.R., Schuitemaker, H., Theodorou, I., Vannberg, F., Veldink, J., Walker, B.D., Weintrob, A., Winkler, C.A., Wolinsky, S., Telenti, A., Goldstein, D.B., De Bakker, P.I., Zagury, J.F., and Fellay, J., Association Study of Common Genetic Variants and HIV-1 Acquisition in 6,300 Infected Cases and 7,200 Controls, PLoS Pathog 9 (7), e1003515 (2013) PMC3723635

7 Manocheewa, S., Swain, J.V., Lanxon-Cookson, E., Rolland, M., and Mullins, J.I., Fitness Costs of Mutations at the HIV-1 Capsid Hexamerization Interface, PLoS ONE 8 (6), e66065 (2013) PMC3681919

8 Mailliard, R., Smith, K.N., Fecek, R.J., Rappocciolo, G., Nascimento, E.J.M., Marques, E.T., Watkins, S.C., Mullins, J.I., and Rinaldo, C.R., Selective Induction of CTL Helper Rather Than Killer Activity by Natural Epitope Variants Promotes Dendritic Cell–Mediated HIV-1 Dissemination, Journal of immunology 191 (5), 2570-80 (2013)

9 Liu, Y., Holte, S., Rao, U., Mcclure, J., Konopa, P., Swain, J.V., Lanxon-Cookson, E., Kim, M., Chen, L., and Mullins, J.I., A Sensitive Real-Time PCR Based Assay to Estimate the Impact of Amino Acid Substitutions on the Competitive Replication Fitness of Human Immunodeficiency Virus Type 1 in Cell Culture, J Virol Methods 189 (1), 157-66 (2013) PMC3608845

10 Lingappa, J.R., Thomas, K.K., Hughes, J.P., Baeten, J.M., Wald, A., Farquhar, C., De Bruyn, G., Fife, K.H., Campbell, M.S., Kapiga, S., Mullins, J.I., Celum, C., and Partners in Prevention, H.S.V.H.I.V.T.S.T., Partner Characteristics Predicting HIV-1 Set Point in Sexually Acquired HIV-1 among African Seroconverters, AIDS research and human retroviruses 29 (1), 164-71 (2013) PMC3537302

11 Larsen, B.B., Chen, L., Maust, B.S., Kim, M., Zhao, H., Deng, W., Westfall, D., Beck, I., Frenkel, L.M., and Mullins, J.I., Improved Detection of Rare HIV-1 Variants Using 454 Pyrosequencing, PLoS One 8 (10), e76502 (2013) PMC3788733

12 Lanxon-Cookson, E.C., Swain, J.V., Manocheewa, S., Smith, R.A., Maust, B., Kim, M., Westfall, D., Rolland, M., and Mullins, J.I., Factors Affecting Relative Fitness Measurements in Pairwise Competition Assays of Human Immunodeficiency Viruses, J Virol Methods 194 (1-2), 7-13 (2013)

13 Kunwar, P., Hawkins, N., Dinges, W.L., Liu, Y., Gabriel, E.E., Swan, D.A., Stevens, C.E., Maenza, J., Collier, A.C., Mullins, J.I., Hertz, T., Yu, X., and Horton, H., Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design, PLoS ONE 8 (5), e64405 (2013) PMC3669284

14 Kulkarni, V., Rosati, M., Valentin, A., Ganneru, B., Singh, A.K., Yan, J., Rolland, M., Alicea, C., Beach, R.K., Zhang, G.M., Le Gall, S., Broderick, K.E., Sardesai, N.Y., Heckerman, D., Mothe, B., Brander, C., Weiner, D.B., Mullins, J.I., Pavlakis, G.N., and Felber, B.K., HIV-1 p24(Gag) Derived Conserved Element DNA Vaccine Increases the Breadth of Immune Response in Mice, PLoS One 8 (3), e60245 (2013) PMC3610668

15 Iyer, S., Bouzek, H., Deng, W., Larsen, B., Casey, E., and Mullins, J.I., Quality Score Based Identification and Correction of Pyrosequencing Errors, PLoS One 8 (9), e73015 (2013) PMC3764156

16 Deng, W., Maust, B.S., Westfall, D.H., Chen, L., Zhao, H., Larsen, B.B., Iyer, S., Liu, Y., and Mullins, J.I., Indel and Carryforward Correction (Icc): A New Analysis Approach for Processing 454 Pyrosequencing Data, Bioinformatics 29 (19), 2402-9 (2013) PMC3777116

17 Campbell, M.S., Kahle, E.M., Celum, C., Lingappa, J.R., Kapiga, S., Mujugira, A., Mugo, N.R., Fife, K.H., Mullins, J.I., Baeten, J.M., and Partners in Prevention, H.S.V.H.I.V.T.S.T., Plasma Viral Loads During Early HIV-1 Infection Are Similar in Subtype C- and Non-Subtype C-Infected African Seroconverters, J Infect Dis 207 (7), 1166-70 (2013) PMC3583276

18 Bull, M.E., Heath, L.M., Mckernan-Mullin, J.L., Kraft, K.M., Acevedo, L., Hitti, J.E., Cohn, S.E., Tapia, K.A., Holte, S.E., Dragavon, J.A., Coombs, R.W., Mullins, J.I., and Frenkel, L.M., Human Immunodeficiency Viruses Appear Compartmentalized to the Female Genital Tract in Cross-Sectional Analyses but Genital Lineages Do Not Persist over Time, J Infect Dis 207 (8), 1206-15 (2013) PMC3603533

 



 

 



 

 

Department of Microbiology · University of Washington · Box 357735 · Seattle WA 98195-7735

phone: (206) 543-5824 · fax: (206) 543-8297 · micro@u.washington.edu