James Mullins
Professor of Microbiology and of Medicine
Adjunct Professor of Laboratory Medicine

Website
COS Profile
Email: jmullins@u.washington.edu
Phone:(206) 732-6163
Office Location: 358B Rosen Building
Campus Box: 358070

Research:

Dr. Mullins obtained his Ph.D. in Cell Biology and Biochemistry from the University of Minnesota in 1978. He did postdoctoral work at the California Institute of Technology before becoming Assistant then Associate Professor at the Harvard University School of Public Health. In 1989 he moved to Stanford University as Professor and was Chairman of the Department of Microbiology and Immunology from 1991 until his move to the University of Washington in 1994 where he is on the faculty of the Departments of Microbiology, Medicine, and Laboratory Medicine. He served as Chair of Microbiology from 1997-2002.

The Mullins lab uses the techniques of molecular, computational and virus biology to provide basic insights into the HIV-human host relationship in an effort to assist the fight to stop the AIDS pandemic. They use a variety of techniques to understand the implications of HIV's extraordinary genetic diversity for the pathogenesis of AIDS, with the intention of applying this information to the development of more effective therapies and vaccines. These techniques include virology, molecular biological and statistical analysis of nucleotide sequences.

Selected Publications:

1 Rolland, M., Tovanabutra, S., Decamp, A.C., Frahm, N., Gilbert, P.B., Sanders-Buell, E., Heath, L., Magaret, C.A., Bose, M., Bradfield, A., O'sullivan, A., Crossler, J., Jones, T., Nau, M., Wong, K., Zhao, H., Raugi, D.N., Sorensen, S., Stoddard, J.N., Maust, B.S., Deng, W., Hural, J., Dubey, S., Michael, N.L., Shiver, J., Corey, L., Li, F., Self, S.G., Kim, J., Buchbinder, S., Casimiro, D.R., Robertson, M.N., Duerr, A., Mcelrath, M.J., Mccutchan, F.E., and Mullins, J.I., Genetic Impact of Vaccination on Breakthrough Hiv-1 Sequences from the Step Trial, Nature medicine 17 (3), 366-71 (2011) PMC3053571

2 Rolland, M., Frahm, N., Nickle, D.C., Jojic, N., Deng, W., Allen, T.M., Brander, C., Heckerman, D.E., and Mullins, J.I., Increased Breadth and Depth of Cytotoxic T Lymphocytes Responses against Hiv-1-B Nef by Inclusion of Epitope Variant Sequences, PLoS ONE 6 (3), e17969 (2011) PMC3065451

3 Niu, L., Termini, J.M., Kanagavelu, S.K., Gupta, S., Rolland, M.M., Kulkarni, V., Pavlakis, G.N., Felber, B.K., Mullins, J.I., Fischl, M.A., and Stone, G.W., Preclinical Evaluation of Hiv-1 Therapeutic Ex Vivo Dendritic Cell Vaccines Expressing Consensus Gag Antigens and Conserved Gag Epitopes, Vaccine 29 (11), 2110-9 (2011) PMC3046258

4 Mullins, J.I., Heath, L., Hughes, J.P., Kicha, J., Styrchak, S., Wong, K.G., Rao, U., Hansen, A., Harris, K.S., Laurent, J.P., Li, D., Simpson, J.H., Essigmann, J.M., Loeb, L.A., and Parkins, J., Mutation of Hiv-1 Genomes in a Clinical Population Treated with the Mutagenic Nucleoside Kp1461, PLoS ONE 6 (1), e15135 (2011) PMC3021505

5 Liu, Y., Mcnevin, J.P., Holte, S., Mcelrath, M.J., and Mullins, J.I., Dynamics of Viral Evolution and Ctl Responses in Hiv-1 Infection, PLoS ONE 6 (1), e15639 (2011) PMC3024315

6 Herbeck, J.T., Rolland, M., Liu, Y., Mclaughlin, S., Mcnevin, J., Zhao, H., Wong, K., Stoddard, J.N., Raugi, D., Sorensen, S., Genowati, I., Birditt, B., Mckay, A., Diem, K., Maust, B.S., Deng, W., Collier, A.C., Stekler, J.D., Mcelrath, M.J., and Mullins, J.I., Demographic Processes Affect Hiv-1 Evolution in Primary Infection before the Onset of Selective Processes, Journal of virology 85 (15), 7523-34 (2011) PMC3147913

7 Campbell, M.S., Mullins, J.I., Hughes, J.P., Celum, C., Wong, K.G., Raugi, D.N., Sorensen, S., Stoddard, J.N., Zhao, H., Deng, W., Kahle, E., Panteleeff, D., Baeten, J.M., Mccutchan, F.E., Albert, J., Leitner, T., Wald, A., Corey, L., and Lingappa, J.R., Viral Linkage in Hiv-1 Seroconverters and Their Partners in an Hiv-1 Prevention Clinical Trial, PLoS ONE 6 (3), e16986 (2011) PMC3047537

8 Baeten, J.M., Kahle, E., Lingappa, J.R., Coombs, R.W., Delany-Moretlwe, S., Nakku-Joloba, E., Mugo, N.R., Wald, A., Corey, L., Donnell, D., Campbell, M.S., Mullins, J.I., and Celum, C., Genital Hiv-1 Rna Predicts Risk of Heterosexual Hiv-1 Transmission, Science translational medicine 3 (77), 77ra29 (2011) PMC3087186

9 Rolland, M., Carlson, J.M., Manocheewa, S., Swain, J.V., Lanxon-Cookson, E., Deng, W., Rousseau, C.M., Raugi, D.N., Learn, G.H., Maust, B.S., Coovadia, H., Ndung'u, T., Goulder, P.J.R., Walker, B.D., Brander, C., Heckerman, D.E., and Mullins, J.I., Amino-Acid Co-Variation in Hiv-1 Gag Subtype C: Hla-Mediated Selection Pressure and Compensatory Dynamics, PLoS ONE 5 (9), e12463 (2010)

10 Lingappa, J.R., Hughes, J.P., Wang, R.S., Baeten, J.M., Celum, C., Gray, G.E., Stevens, W.S., Donnell, D., Campbell, M.S., Farquhar, C., Essex, M., Mullins, J.I., Coombs, R.W., Rees, H., Corey, L., Wald, A., and For the Partners in Prevention, H.S.V.H.I.V.T.S.T., Estimating the Impact of Plasma Hiv-1 Rna Reductions on Heterosexual Hiv-1 Transmission Risk, PLoS One 5 (9), e12598 (2010)

11 Huang, X.L., Fan, Z., Borowski, L., Mailliard, R.B., Rolland, M., Mullins, J.I., Day, R.D., and Rinaldo, C.R., Dendritic Cells Reveal a Broad Range of Mhc Class I Epitopes for Hiv-1 in Persons with Suppressed Viral Load on Antiretroviral Therapy, PLoS ONE 5 (9), e12936 (2010) PMC2944894

12 Herbeck, J.T., Gottlieb, G.S., Winkler, C.A., Nelson, G.W., An, P., Maust, B.S., Wong, K.G., Troyer, J.L., Goedert, J.J., Kessing, B.D., Detels, R., Wolinsky, S.M., Martinson, J., Buchbinder, S., Kirk, G.D., Jacobson, L.P., Margolick, J.B., Kaslow, R.A., O'brien, S.J., and Mullins, J.I., Multistage Genomewide Association Study Identifies a Locus at 1q41 Associated with Rate of Hiv-1 Disease Progression to Clinical Aids, J Infect Dis 201(4), 618-26 (2010)

13 Heath, L., Frenkel, L.M., Foley, B.T., and Mullins, J.I., Comment on "the Origins of Sexually Transmitted Hiv among Men Who Have Sex with Men", Science Translational Medicine 2 (50), 50le1-le1 (2010)

14 Dinges, W.L., Richardt, J., Friedrich, D., Jalbert, E., Liu, Y., Stevens, C.E., Maenza, J., Collier, A.C., Geraghty, D.E., Smith, J., Moodie, Z., Mullins, J.I., Mcelrath, M.J., and Horton, H., Virus Specific Cd8+ T Cell Responses Better Define Hiv Disease Progression Than Hla Genotype, J Virol 84 (9), 4461-8 (2010)

15 Deng, W., Maust, B.S., Nickle, D.C., Learn, G.H., Liu, Y., Heath, L., Kosakovsky Pond, S., and Mullins, J.I., Divein: A Web Server to Analyze Phylogenies, Sequence Divergence, Diversity, and Informative Sites,Biotechniques 48 (5), 405-8 (2010)

16 Curlin, M.E., Zioni, R., Liu, Y., Deng, W., Gottlieb, G.S., Zhu, T., and Mullins, J.I., Hiv-1 Envelope Subregion Length Variation During Disease Progression PLoS Pathog 16 (6), e1001228 (2010) PMCPMC3002983

17 Boutwell, C.L., Rolland, M.M., Herbeck, J.T., I., M.J., and Allen, T.A., Viral Evolution and Escape During Acute Hiv-1 Infection, J Infect Dis 202 (S2), S309-S14 (2010)

18 Troyer, R.M., Mcnevin, J., Liu, Y., Zhang, S.C., Krizan, R.W., Abraha, A., Tebit, D.M., Zhao, H., Avila, S., Lobritz, M.A., Mcelrath, M.J., Le Gall, S., Mullins, J.I., and Arts, E.J., Variable Fitness Impact of Hiv-1 Escape Mutations to Cytotoxic T Lymphocyte (Ctl) Response, PLoS Pathog 5 (4), e1000365 (2009)

19 Liu, Y., Woodward, A., Zhu, H., Andrus, T., Mcnevin, J., Lee, J., Mullins, J.I., Corey, L., Mcelrath, M.J., and Zhu, T., Preinfection Human Immunodeficiency Virus (Hiv)-Specific Cytotoxic T Lymphocytes Failed to Prevent Hiv Type 1 Infection from Strains Genetically Unrelated to Viruses in Long-Term Exposed Partners, J Virol 83 (20), 10821-9 (2009) PMC2753147

20 Liu, Y., Mcnevin, J., Rolland, M., Zhao, H., Deng, W., Maenza, J., Stevens, C.E., Collier, A.C., Mcelrath, M.J., and Mullins, J.I., Conserved Hiv-1 Epitopes Continuously Elicit Subdominant Cytotoxic T-Lymphocyte Responses, J Infect Dis 200 (12), 1825-33 (2009)