**PLEASE NOTE DAY AND LOCATION**
April 21, 2014, 4:00 PM, D-209 Health Sciences Building
Benjamin R. tenOever, Ph.D.
Professor, Department of Microbiology
Fishberg Professor, Department of Medicine
Ichan School of Medicine at Mount Sinai
"Adventures in microRNAs and microbe manipulation"
The tenOever lab broadly focuses on the molecular interactions between viruses and their host. More specifically, the lab is interested in the host antiviral response and the means by which the virus circumvents these activities to propagate the infection. This research encompasses the study of cellular antiviral proteins and small RNAs, of both cellular and virus origin, which contribute to the outcome of infection. For this seminar - I will discuss the interplay between viruses and microRNAs and how this knowledge can be used to generate a new toolbox of virus-based tools.
Neal Groman Lecture
April 22, 2014, 4:00 PM, A-420 Hogness Auditorium
Jorge E. Galán, D.V.M., Ph.D.
Lucille P. Markey Professor of Microbiology
Chair of the Department of Microbial Pathogenesis
Yale University School of Medicine
"Typhoid toxin, a window in the biology of Salmonella typhi"
Salmonella Tyhi continues to be a serious global health concern, resulting in more than 200,000 annual deaths. A distinguishing feature of S. Typhi is that it only infects humans, causing a life-threatening systemic infection known as "typhoid fever". This is in sharp contrast to most other Salmonellae, which can infect a variety of hosts and are usually associated with self-limiting gastroenteritis (i. e. "food poisoning"). The molecular bases for Salmonella Typhi's unique pathogenesis and host specificity will be discussed.