HIGH RESOLUTION IMAGING AND SPECTROSCOPY CORE FACILITY

14 Tesla (600 MHz) High Resolution IMaging (HRIM)

The High Resolution Nuclear Magnetic Resonance (NMR) Spectroscopy, Magnetic Resonance Imaging (MRI), and Magnetic Resonance Spectroscopy (MRS) Core Facility at the South Lake Union campus assists researchers from the University of Washington Mitochondria and Metabolism Center and the research community at large.

The facility is capable of multi-nuclear, high resolution NMR as well as in vivo MRS and micro MRI.  All projects are welcome.

Facility

The cornerstone of the facility is a state-of-the-art 14 Tesla (600 MHz) vertical wide bore Bruker Magnetic Resonance Spectrometer. The magnet system is fully equipped for NMR and provides cost effective in vivo MRI and MRS in small animals, such as mice.

It is equipped with a sample temperature control unit and a biological sensor system directly linked to the instrument, allowing animal monitoring and control of studies.  The laboratory has a satellite workstation for data processing, a lab bench area for sample/animal preparation, an isoflurane anesthesia system for  in-vivo work, and a small refrigerator for temporary storage of samples and reagents.

The facility is currently approved for non-survival and survival work at the BSL-1 and BSL-2 levels and can be added to researchers’ protocols at these levels. Please review our Lab Safety Resources page to find links to the UW IACUC and their required forms.

Equipment and Software

High Resolution Spectroscopy

Software: TOPSPIN (Bruker-Biospin)

Imaging

Software: ParaVision (Bruker-Biospin)