Rong Tian, MD, PhD
Director of Mitochondria and Metabolism Center
Professor of Anesthesiology & Pain Medicine, and Bioengineering
Adjunct Professor, Biochemistry and Pathology
My research focuses on the molecular mechanisms regulating cell metabolism and energetics. A long-term goal of my laboratory is to understand the role of mitochondria and metabolism in the pathogenesis of human diseases, in particular cardiovascular diseases.We have utilized molecular and genetic approaches to identify and perturb specific regulators in the key pathways of cardiac energy metabolism in mice and subsequently interrogated the physiological and biochemical responses in vivo during the development of heart failure using multi-nuclear NMR spectroscopy. Our past work focused on the oxidative metabolism and mitochondrial ATP synthesis in heart failure using mouse models of altered glucose and fatty acid metabolism in the heart. Our recent work seeks to decipher the mechanistic links between impaired oxidative phosphorylation and mitochondria-triggered cell death during chronic stresses. Results of these studies identified an important role of cellular redox state in diseases caused by mitochondrial dysfunction including cardiovascular and neurological pathologies.
The three key areas are:
- Energy metabolism in cardiovascular diseases
- Mitochondrial dysfunction and metabolic signaling
- NMR spectroscopy and Imaging-guided spectroscopy
Rong Tian describes her path to becoming a leader in Cardiovascular Science in the following article featured in Circulation Research: http://circres.ahajournals.org/content/120/10/1542
Honors and Awards
2004 Young Investigator Award of the American Physiological Society
2003-07 Established Investigator of the American Heart Association
2008 Elected to American Society of Clinical Investigation
2010 Distinguished Achievement Award of the American Heart Association Basic Science Council
2017 College of Fellows, American Institute for Medical and Biological Engineering
2017 Research Achievement Award of the International Society for Heart Research
2017 Bernard and Joan Marshall Distinguished Investigator, British Society for CV Research
All publications can be found at the following link: All Publications
- Lee CF, Chavez J, Garcia-Menendez L, Choi YS, Roe N, Chiao YA, Edgar J, Goo YA, Goodlett, Bruce J, Tian R. Normalization of NAD+ Redox Balance as a Therapy for Heart Failure. Circulation 2016 Sep 20;134(12):883-94.
- Li T, Zhang Z, Kolwicz Jr. SC, Abell L, Roe ND, Kim M, Zhou B, Cao Y, Ritterhoff J, Gu H, Raftery D, Sun H, Tian R. Defective branched-chain amino acid (BCAA) catabolism disrupts glucose metabolism and sensitizes the heart to ischemia-reperfusion injury. Cell Metab. 2017 Feb 7;25(2):374-385.
- Wang W, Karamanlidis G, Tian R. Novel targets for mitochondrial medicine. Sci Transl Med. 2016 Feb 17;8(326):326rv3. doi: 10.1126/scitranslmed.aac7410. Review. PubMed PMID: 26888432.
- Kim M, Hunter RW, Garcia-Menendez L, Gong G, Yang YY, Kolwicz SC Jr, Xu J, Wang W, Sakamoto K, Tian R. Mutation in the γ2-subunit of AMPK stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage. Circ Res. 2014 Mar 14;114(6):966-75. Epub 2014 Feb 6.
- Karamanlidis G, Lee CF, Garcia-Menendez L, Kolwicz Jr. SC, Suthammarak W, Gong G, Sedensky MM, Morgan PG, Wang W, Tian R. Mitochondria Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metab. 2013 Aug 6;18(2):239-50.
- Kolwicz, Jr. SC, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R. Cardiac-specific deletion of acetyl CoA carboxylase 2 (ACC2) prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res 2012, Aug 31; 111(6): 728-38. PMID: 22730442.
- Yan J, Young ME, Cui L, Lopaschuk GD, Liao R, Tian R. Increased glucose uptake and oxidation in mouse hearts prevents high fatty acid oxidation but causes cardiac dysfunction in diet-induced obesity. Circulation. 2009; 119:2818-2828. Epub 2009 May 18. PMID:19451348 PMCID: PMC2765220
- Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M , Seidman CE, Seidman JG, Ingwall JS ,Balschi JA, Tian R. Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest. 2007 May;117(5):1432-9. Epub 2007 Apr 12. PMID:17431505 PMCID: PMC1847536
Laboratory: Tian Lab