Wang Wang, MD, PhD

  • Researcher, Mitochondria and Metabolism Center
  • Assistant Professor, Anesthesiology and Pain Medicine

Research

  • Cardiac bioenergetics and mitochondrial function regulation
  • Intracellular signaling pathways and therapeutic targets of heart failure
  • Mitochondrial dysfunction in neurodegenerative disease
  • Confocal imaging and in vivo evaluation of mitochondrial function

Awards

  • National Institutes of Health,  Fellow Award for Research Excellence (2003 & 2004)
  • International Society for Heart Research (ISHR), Richard J. Bing Award for Young Investigators (2007)

Current Memberships

  • American Heart Association
  • American Physiological Society
  • Biophysical Society
  • International Society for Heart Research

Current Funding

  • American Heart Association Scientist Development Grant: Activation and role of mitochondrial permeability transition pore in cardiac excitation contraction coupling.
  • National Institutes of Health (R01, PI: Tian, R.): Complex I deficiency triggered acceleration of heart failure.
  • National Institutes of Health (R01, PI: Wang, W): Mitochondrial Respiration and Superoxide Production in Healthy and Failing Heart.

Selected Publications

  • Wang Wang, Matthew S. Barnabei, Michelle Asp, Frazer Heinis, Erik Arden, Jennifer Davis, Elizabeth Braunlin, Qi Li, Jonathan Davis, James D. Potter, Joseph M. Metzger. Noncanonical EF-hand Motif Strategically Delays Ca2+ Buffering to Enhance Cardiac Performance. Nat. Med. In press. 2013.
  • Zhanglong Huang, Wanrui Zhang, Guohua Gong, Huaqiang Fang, Ming Zheng, Xianhua Wang, Jiejia Xu, Robert T. Dirksen, Shey-Shing Sheu, Heping Cheng, Wang Wang. Response to “A critical evaluation of cpYFP as a probe for superoxide”. Free Radic. Biol. Med. 51, 1937-1940, 2011.
  • Wang Wang*, Huaqiang Fang, Linda Groom, Aiwu Cheng, Wanrui Zhang, Jie Liu, Xianhua Wang, Kaitao Li, Peidong Han, Ming Zheng, Jinhu Yin, Weidong Wang, Mark P. Mattson, Joseph P. Y. Kao, Edward G. Lakatta, Shey-Shing Sheu, Kunfu Ouyang, Ju Chen, Robert T. Dirksen, Heping Cheng*. Superoxide flashes in single mitochondria. Cell. 134, 279-290, 2008. (*: corresponding authors)
  • Carlo G. Tocchetti*, Wang Wang*, Jeffrey P. Froehlich*, Sabine Huke, Miguel A. Aon, Gerald M. Wilson, Giulietta Di Benedetto, Brian O’ Rourke, Wei Dong Gao, David A. Wink, John P. Toscano, Manuela Zaccolo, Donald M. Bers, Hector H. Valdivia, Heping Cheng, David A. Kass, Nazareno Paolocci. Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ. Res. 100, 96-104, 2007. (*: co-first authors)
  • Wang Wang, Weizhong Zhu, Shiqiang Wang, Dongmei Yang, Michael T. Crow, Rui-Ping Xiao, Heping Cheng. Sustained β1-adrenergic stimulation modulates cardiac contractility by Ca2+/calmodulin kinase signaling pathway. Circ. Res. 95, 798-806, 2004.

Wang Lab

Contact Information

Mitochondria and Metabolism Center
850 Republican St, Room N121
Seattle, WA  98109-8057
Phone: 206-685-4765
Fax: 206-616-4819
Email: Wang Wang