Wang Wang, MD, PhD

  • Researcher, Mitochondria and Metabolism Center
  • Assistant Professor, Anesthesiology and Pain Medicine
  • Adjunct Assistant Professor of Pathology

Research Interests

The overall goal of my research is to identify novel molecular mechanisms and signaling pathways that orchestrate metabolism and cell function as well as to understand how they contribute to human disease. I have a broad background in medicine, physiology and pathology, with extensive trainings in medicine, molecular and cellular biology, biophysics, mitochondrial biology and cardiovascular physiology. Particularly, my development of a novel intra-mitochondrial superoxide indicator and the discovery of a bursting superoxide event in individual mitochondria of live cells are breakthrough advancement in the bioenergetics field. In addition, I have investigated the role of beta-adrenergic signaling and protein modification in cardiac excitation contraction coupling and developed novel genetic approaches for the treatment of diastolic heart failure. I have developed independent and collaborative research programs to systematically investigate the interplay among mitochondrial respiration, free radical generation, calcium handling and morphological dynamics. We are funded to study how excitation contraction coupling modulates mitochondrial function and how individual mitochondrion contributes to stress-induced human disease such as heart failure, diabetes and neurodegeneration. We are especially interested in the novel role of mitochondrial dynamics regulators in health and disease. 

  • Cardiovascular bioenergetics and mitochondrial funciton regulation
  • Metabolic pathways and therapeutic targets in heart failure
  • Mitochondrial dysfunction in neurodegenerative disease
  • Confocal imaging and in vivo evaluation of mitochondrial function

Honors and Awards

  • National Institutes of Health,  Fellow Award for Research Excellence (2003 & 2004)
  • International Society for Heart Research (ISHR), Richard J. Bing Award for Young Investigators (2007)
  • The Academy of Cardiovascular Research Excellence (ACRE) Young Investigator Award (2011)

Current Memberships

  • American Heart Association
  • American Physiological Society
  • American Society for Biochemistry and Molecular Biology
  • Biophysical Society
  • International Society for Heart Research

Current Funding

  • American Heart Association Scientist Development Grant: Activation and role of mitochondrial permeability transition pore in cardiac excitation contraction coupling.
  • National Institutes of Health (R01, PI: Tian, R.): Complex I deficiency triggered acceleration of heart failure.
  • National Institutes of Health (R01, PI: Wang, W): Mitochondrial Respiration and Superoxide Production in Healthy and Failing Heart.

Recent Publications

  • Guohua Gong, Xiaoyun Liu, Wang Wang. Regulation of metabolism in individual mitochondria during excitation-contraction coupling. J Mol Cell Cardiol. 76, 235, 2014.
  • Jin O-Uchi, Bong Sook Jhun, Shangcheng Xu, Stephen Hurst, Anna Raffaello, Xiaoyun Liu, Bing Yi, HuIliang Zhang, Polina Gross, Jyotsna Mishra, Alina Ainbinder, Sarah Kettlewell, Godfrey L. Smith, Robert T. Dirksen, Wang Wang, Rosario Rizzuto, Shey-Shing Sheu. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid. Redox Signal. Antioxid Redox Signal. 21, 863, 2014.
  • Georgios Karamanlidis, Chi Fung Lee, Lorena Garcia-Menendez, Stephen C. Kolwicz, Jr., Wichit Suthammarak, Guohua Gong, Margaret M. Sedensky, Philip G. Morgan, Wang Wang, and Rong Tian. Mitochondrial Complex I Deficiency Increases Protein Acetylation and Accelerates Heart Failure. Cell Metab. 18, 239-250, 2013.
  • Guohua Gong, Wang Wang. Confocal Imaging of Single Mitochondrial Superoxide Flashes in Intact Heart and in vivo. J. Vis. Exp. e50818, 2013.
  • Lan Wei-LaPierre, Guohua Gong, Brent J. Gerstner, Sylvie Ducreux, David I. Yule, Sandrine Pouvreau, Xianhua Wang, Shey-Shing Sheu, Heping Cheng, Robert T. Dirksen, Wang Wang. Respective Contribution of Mitochondrial Superoxide and pH to Mt-cpYFP Flash Activity. J. Biol. Chem. 288, 10567-10577, 2013.
  • Wang Wang, Matthew S. Barnabei, Michelle Asp, Frazer Heinis, Erik Arden, Jennifer Davis, Elizabeth Braunlin, Qi Li, Jonathan Davis, James D. Potter, Joseph M. Metzger. Noncanonical EF-hand Motif Strategically Delays Ca2+ Buffering to Enhance Cardiac Performance. Nat. Med. 19, 305-312, 2013.
  • Wang Wang*, Huaqiang Fang, Linda Groom, Aiwu Cheng, Wanrui Zhang, Jie Liu, Xianhua Wang, Kaitao Li, Peidong Han, Ming Zheng, Jinhu Yin, Weidong Wang, Mark P. Mattson, Joseph P. Y. Kao, Edward G. Lakatta, Shey-Shing Sheu, Kunfu Ouyang, Ju Chen, Robert T. Dirksen, Heping Cheng*. Superoxide flashes in single mitochondria. Cell. 134, 279-290, 2008. (*: corresponding authors)

Wang Lab

Contact Information

Mitochondria and Metabolism Center
850 Republican St, Room N121
Seattle, WA  98109-8057
Phone: 206-685-4765
Fax: 206-616-4819
Email: Wang Wang