Molecular Medicine Seminar 2008

01.08.08

Dr. Janet Eary--Course Intro/Imaging sarcoma treatment resistance

• Fluorodeoxyglucose Positron Emission Tomography Predicts Outcome for Ewing Sarcoma Family of Tumors
• Fluorodeoxyglucose Positron Emission Tomography Scanning: Basic Principles and Imaging of Adult Soft-Tissue Sarcoma

01.10.08

Dr. Jay Heinecke--Proteomic analysis of vascular inflammation and lipid deposition

• What does it mean to identify a protein in proteomics?
• Mass spectrometry-based proteomics

01.15.08

Dr. Jash Unadkat--The importance of transporters in drug disposition, efficacy and toxicity

• Mitochondrial Expression of the Human Equilibrative Nucleoside Transporter 1 (hENT1) Results in Enhanced Mitochondrial Toxicity of Antiviral Drugs
• Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography
• Transporters as a determinant of drug clearance and tissue distribution
• Presentation Slides

Dr. Jeanne Link--Imaging apoptosis: challenges and successes

• Evaluation of 18F-Annexin V as a PET Imaging Agent in an Animal Model of Apoptosis

Dr. Jan Abkowitz--Red cell production, FLV and anemia

Dr. Mark Wurfel--Human immune polymorphisms and impact on health

• Selective predisposition to bacterial infections in IRAK-4-deficient children
• A tutorial on statistical methods for population association studies
• A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis

Dr. Ray Yeung--TSC1 tumor suppressor genes

• Activated Mammalian Target of Rapamycin Pathway in the Pathogenesis of Tuberous Sclerosis Complex Renal Tumors
• The Tuberous Sclerosis Complex
• mTOR and cancer: insights into a complex relationship

Dr. Andy Scharenberg--Lymphocytes and adaptive immunity

• Agammaglobulinemia
• Have We Seen the Last Variant of Severe Combined Immunodeficiency?
• Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency
• LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1
• Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

Dr. David Mankoff--Estrogen receptor imaging in breast cancer

• Molecular Imaging Research in the Outcomes Era: Measuring Outcomes for Individualized Cancer Therapy

• Tumor-Specific Positron Emission Tomography Imaging in Patients

Dr. Jeanine McCune--Drug therapy monitoring for hematologic malignancy

• The Art and Science of Personalized Medicine
• Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
• Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantation

Dr. Jim Caldwell--Myocardial receptor imaging

• Evidence for Pre- to Postsynaptic Mismatch of the Cardiac Sympathetic Nervous System in Ischemic Congestive Heart Failure

Dr. Lalita Ramakrishnan--Tuberculosis

• Superinfecting mycobacteria home to established tuberculous granulomas
• Mutual attraction: Does it benefit the host or the bug?
• Tuberculous granuloma formation is enhanced by a mycobacterium virulence determinant
• A clear view of mycobacterial infection

Dr. Regina Wender--Hydrogen Sulfide and Suspended Animation:  National Enquirer Headline?? or Molecular Medicine??

• H2S Induces a Suspended Animation-Like State in Mice
• Hydrogen Sulphide and its Therapeutic Potential
• A New Gaseous Signalling Molecule Emerges: Cardioprotective Role of Hydrogen Sulfide

Dr. Scott Weigle--Clinical aspects of obesity

• Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
• Central Nervous System Control of Food Intake and Body Weight

Dr. David Eyre--Collagen-based biomarkers of bone and joint disease

• Advances in Therapy for Osteoporosis

• Osteoarthritis in 2007

• Endocrine regulation of energy metabolism by the skeleton

Dr. Lawrence Loeb--Cancers express a mutator phenotype: origin and consequences

• Human cancers express a mutator phenotype
• Random mutations, selected mutations: A PIN opens the door to new genetic landscapes

Dr. Cassian Yee--Melanoma

• Recent advances in the use of antigen-specific T cells for the treatment of cancer
• Adoptive T cell therapy: Addressing challenges in cancer immunotherapy
• Adoptive T cell therapy of cancer

Dr. Susan Ott--Bone metabolism and osteoporosis

• Regulation of bone mass by Wnt signaling
• Editorial: Sclerostin and Wnt Signaling--The Pathway to Bone Strength
• The Role of Receptor Activator of Nuclear Factor-KB (RANK)/RANK Ligand/Osteoprotegerin: Clinical Implications
• RANKL and OPG Regulation of Bone Remodeling

Dr. Paul Pottinger--Antimicrobial drug resistance

• Vaccine protection against Staphylococcus aureus pneumonia
• Emergence of Community-Acquired Methicillin-Resistant Staphylococcus Aureus USA 300 Clone as the Predominant Cause of Skin and Soft-Tissue Infections
• Extended-spectrum Beta-lactamase-producing Enterobacteriaceae: an emerging public-health concern
• Real-time quantification of Pseudomonas florescens cell removal from glass surfaces due to bacteriophage varphi S1 application