Kyle Jacoby

Department: Molecular and Cellular Biology
Year Entered: 2008
Prior Degrees: BA in Biology, University of California Santa Barbara, 2008

Research Synopsis:
My research and career interests span many classical categories of science, but generally include the exploration and development of novel biological tools for their clinical or practical application. For example, I am currently attempting to use homology and directed evolution approaches to better understand homing endonucleases. I will use this understanding along with directed evolution and a collaborative computational design effort to attempt to modify their specificities toward clinically relevant targets. I enjoy integrating many different biological disciplines in order to find the best solution and tackle a given problem. I am participating in the certificate program because I believe my research interests align well with strengths and goals of the program.

Publications:
Aoki SK, Malinverni JC, Jacoby K, Thomas B, Pamma R, Trinh BN, Remers S, Webb J, Braaten BA, Silhavy TJ, Low DA. Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB. Mol Microbiol. 2008 Oct;70(2):323-40.