Ken Lindsay

Ryan Larson

Department: Biochemistry
Year Entered: 2007
Prior Degrees: BS, University of Washington, 2007

Research Synopsis:
I am currently a graduate student in the lab of James B. Hurley of the Department of Biochemistry, here at the University of Washington, where I am studying photoreceptor metabolism as it relates to the photoreceptor cell’s altering energy demand in light and dark adaptation and further, how this relates to photoreceptor cell degeneration.

Due to its unique morphology and role with retina, the photoreceptor cells represents a incredible source of questions regarding how the basic metabolism of cell relates to cell degeneration and for this model; the maintenance of one’s sight.

One of the main foci of my research has been to study how the photoreceptor cell harnesses its mitochondria to respond to new demands as it adapts to light and dark conditions. In addition, as a means of studying cellular energetics, the photoreceptor cell represents a intriguing model of how the Phosphocreatine Energy Circuit operates within the cell, as a buffering mechanism and as a means of shuttling energy to distant processes in the cell. By studying how these processes work together, we will be able to more closely understand a synergistic process for maintaining energy levels within the cell.

My interest in the molecular medicine program stems from a desire to apply my knowledge of the mechanics of cellular health from a biochemistry foundation towards the improvement of modern medicine as in applies to the betterment of human health, thus bridging the gap between the lab bench and the bedside.