phenotype function WRN mutation database

maRTA RecQ analyses maRTA protocols

structure engineering gene targeting disease prevention

The Monnat Lab is located in the Departments of Pathology and Genome Sciences at the University of Washington School of Medicine in Seattle. Our research focuses on human RecQ helicase deficiency syndromes such as Werner syndrome, high resolution analyses of DNA replication dynamics, and the engineering of homing endonucleases for targeted gene modification in human cells. Click on any of the photos above for more information on these research projects, and see our Publications page for recent manuscripts from work in each of these areas. Our research is supported by awards from: