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The Monnat Lab is located in the Departments of Pathology and Genome Sciences at the University of Washington School of Medicine in Seattle. Our research is focused on three inter-related areas: human RECQ helicase deficiency syndromes such as Werner syndrome and the role of RECQ helicases in cancer; high resolution analyses of DNA replication dynamics; and genome engineering enabled by the design or engineering of highly site-specific homing endonuclease proteins. Click on any of the photos above for more information on these research projects. Our Publications page also includes our manuscripts from work in each of these areas. Our research is supported by awards from: