Research Highlight #1

In vivo coupling of oxidative phosphorylation is inversely proportional to oxidative stress.

Research Highlight #2

New data indicate the fast-twitch muscle is more susceptible to oxidative stress induced changes in mitochondrial metabolism and that this response changes with age.

Research Highlight #1

In vivo coupling of oxidative phosphorylation is inversely proportional to oxidative stress. These results are the first in vivo support of the “Uncoupling to Survive” hypothesis that reduced coupling of oxidative phosphorylation is a defense against reactive oxygen species production by the mitochondria. Experiments are underway to determine mechanisms underlying the reduced coupling and whether the effect is diminished with age.

Abstracts

Siegel M, Knowles G, Harper M-E, Marcinek DJ. Oxidative stress leads to reduced coupling of oxidative phosphorylation in in vivo resting mouse skeletal muscle. Experimental Biology Conference April 2010, Anaheim, CA

Siegel M, Harper M-E, Marcinek DJ. The absence of UCP3 does not alter coupling of oxidative phosphorylation in resting skeletal muscle. Experimental Biology Conference, April 2009. New Orleans, LA.

Research Highlight #2

The adaptive response to oxidative stress varies with muscle fiber type and age. New data indicate the fast-twitch muscle is more susceptible to oxidative stress induced changes in mitochondrial metabolism and that this response changes with age.

Abstracts

David J. Marcinek, Jason Villarin, and Shane Kruse. Oxidative stress leads to a decline in mitochondrial capacity in aged fast-twitch, but not slow-twitch muscle. Experimental Biology. April, 2010. Anaheim, CA.

Villarin JJ, Conley KE, Kushmerick MJ, Marcinek DJ. Oxidative metabolism in aged mouse soleus and EDL muscle.  Experimental Biology Conference, 2009. New Orleans, LA.

Marcinek DJ, Smith SR, Van Remmen H. Increased mitochondrial capacity due to chronic oxidative stress is reduced with age. Experimental Biology Conference. April 2009. New Orleans, LA.