Kannan Krishnan

2012 IEEE Donald G. Fink Prize Paper Award

Professor Krishnan IEEE Press Release about Donald G. Fink Prize Paper Award.



Paper Provides a Comprehensive Overview of Biomedical Nanomagnetics
and its Applications to Medicine


PISCATAWAY, N.J. (12 April 2011) – Kannan M. Krishnan, an engineer who has applied his expertise in biomedical nanomagnetics to provide a much-needed paper detailing the advances and challenges in using magnetic nanoparticles for medical applications, is being honored by IEEE with the 2012 IEEE Donald G. Fink Prize Paper Award. IEEE is the world’s largest technical professional association.
The award, sponsored by the IEEE Life Members Committee and given to an outstanding survey, review or tutorial paper appearing in any of the IEEE Transactions, Proceedings of the IEEE, journals or magazines, recognizes Krishnan for his paper “Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics and Therapy,” which appeared in the July 2010 issue of the IEEE Transactions on Magnetics (vol. 46, no. 7, pp. 2523–2558). The award will be presented on 9 May 2012 at the IEEE International Magnetics Conference in Vancouver, Canada.
Biomedical nanomagnetics is a rapidly evolving, cutting-edge multidisciplinary field that impacts engineering, physical science and medicine. Biomedical nanomagnetics aims to detect disease at the earliest possible time through diagnostics and imaging. It also addresses the challenge of delivering treatment at the right place and at the right time while minimizing unnecessary exposure through targeted therapy with a triggered release. Krishnan’s paper makes this interdisciplinary topic accessible to physicists, chemists, biologists and engineers, and it is considered required reading for both experts and newcomers to the field.
Because the field is progressing so rapidly, there seems to be a lack of comprehensive textbooks or review articles. However, Krishnan’s paper is able to provide extensive coverage of magnetic nanoparticle synthesis and its implications for medical imaging, diagnostics and therapy. Krishnan addresses targeted drug delivery for cancer treatment, novel contrast agents for magnetic resonance imaging, cancer therapy using magnetic hyperthermia, in vitro diagnostics based on magnetic nanoparticles and the recently developed magnetic particle imaging technique.
Krishnan presents the relevant physics of nanoscale magnetic particles and reviews the synthesis and characterization of these particles. He discusses the practical necessities for modifying particle surface chemistry to address in vivo applications while also conforming to U.S. Food and Drug Administration regulations. And readers are brought up-to-date with advances, challenges and opportunities in the field.
A substantial portion of the paper reviews research on the exciting new imaging modality of magnetic particle imaging and puts it into context with other imaging methods. Magnetic particle imaging has many characteristics of positron emission tomography but without the need for radionuclide biomarkers. It directly determines the three-dimensional spatial density of magnetic nanoparticles by performing tomography based on the locally defined low-frequency alternating-current susceptibility of biofluid. Magnetic particle imaging can quickly and quantitatively measure processes like blood flow, and research on developing a commercial instrument has shown resolution as fine as one millimeter. Krishnan has been one of the pioneers of magnetic particle imaging and optimizing the magnetic particles to provide the best contrast.
An IEEE Senior Member, Krishnan is a Fellow of the American Association for the Advancement of Science, the American Physical Society and the Institute of Physics (London). His honors include the Burton Medal from the Microscopy Society of America (1992), the University of Washington College of Engineering Outstanding Educator Award (2004), the IEEE Magnetics Society Distinguished Lecturer Award (2009) and a Fulbright Specialist Award (2010). He received his bachelor of technology degree in mechanical engineering from the Indian Institute of Technology, Kanpur, India, his master’s degree from the State University of New York at Stony Brook and doctorate from the University of California, Berkeley. Krishnan is currently a professor with the Department of Materials Science and Physics at the University of Washington, Seattle.

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