The weekly seminar series organized by CNT and the Molecular Engineering and Sciences Institute provides a forum for bringing national and international leaders in nanoscale science and technology to campus, and for graduate students enrolled in our Dual Ph.D. program in Nanotechnology to present their research.
All seminars are held on Tuesdays from 2:30 to 3:20 PM in Johnson Hall Room 102 (North end of building and across from MolE).
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Models and measurements of molecular motors in moving muscle: new views of classic problems
Prof. Tom Daniel, University of Washington - Biology
The constraint of constant volume for a contracting muscle cell implies a radial expansion that occurs during axial shortening will lead to increases in the radial spacing of the lattice of myofilaments. That change in filament spacing, in turn, can have a profound effect on the attachment rate of molecular motors that generate force (cross-bridges). At the same time, cross-bridges attaching to thin filaments and generating axial forces and may simultaneously restrict the extent to which the filament lattice can expand or contract in the radial direction as muscle shortens. This talk combines computational and experimental approaches to understand radial changes in the lattice in muscle. From Amazon Web Services to high speed time resolved X-ray diffraction we show how muscle function is crucially dependent on a direction of force and motion that has been neglected.
Copyright © 2012 The Center for Nanotechnology at the University of Washington