Past Seminars

The weekly seminar series organized by CNT and the Molecular Engineering and Sciences Institute provides a forum for bringing national and international leaders in nanoscale science and technology to campus, and for graduate students enrolled in our Dual Ph.D. program in Nanotechnology to present their research.

All seminars are held on Tuesdays from 2:30 to 3:20 PM in Johnson Hall Room 102 (North end of building and across from MolE).

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Seminars

2013-01-15

Thermo-targeted Chemotherapy to Clean Dirty Tumor Margins

Asst. Prof. Darin Furgeson, University of Utah - Dept. of Pharmaceutics & Pharmaceutical Chemistry
Speaker's Website
Prof. Patrick S. Stayton, Dept. of Bioengineering

The tumor margins are the barrier to hepatocellular carcinoma (HCC) eradication for tumors greater than 3 cm. Indeed, inadequately treated tumor margins commonly result in cancer recurrence with increased tumor size and mass. This presentation details a new synergistic approach for combining (i) focal locoregional, percutaneous microwave thermal ablation for HCC core destruction and induction of sub-lethal, hyperthermic ablative margins for (ii) site-specific delivery of thermosensitive biopolymer-geldanamycin conjugates. As will be discussed, this unique approach provides several advantages over current clinical thermal ablation strategies by simultaneously destroying the HCC core from the inside out and the HCC ablative margins from the outside-in.