Past Seminars

The weekly seminar series organized by CNT and the Molecular Engineering and Sciences Institute provides a forum for bringing national and international leaders in nanoscale science and technology to campus, and for graduate students enrolled in our Dual Ph.D. program in Nanotechnology to present their research.

All seminars are held on Tuesdays from 2:30 to 3:20 PM in Johnson Hall Room 102 (North end of building and across from MolE).

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Seminars

2013-04-16

Programmable Nanotherapeutics and Organs on Chips

Donald E. Ingber, M.D., Ph.D., Harvard University - Bioengineering
Speaker's Website
Shaoyi Jiang, Chemical Engineering

In this presentation, I will describe work we have been carrying out in the Biomimetic Microsystems and Programmable Nanomaterials platforms at the Wyss Institute for Biologically Inspired Engineering at Harvard, as well as our new model for innovation, collaboration and technology translation. The goal of the first platform is to engineer human 'Organs-on-Chips': microchips lined by living human cells created with microfabrication techniques that recapitulate organ-level functions as a way to replace animal testing for drug development. I will review recent advances we have made in development of multiple organ chips, including human lung, gut and bone marrow chips. I will also describe our ongoing efforts to develop more than 10 different organ chips, to integrate them into a 'human body on chips', and to engineer an automated instrument for real-time analysis of cellular responses to pharmaceuticals, toxins and other chemicals. The goal of the second platform is to create multi-functional nanotechnologies for regenerative medicine and drug delivery applications, with the long-term goal of developing injectable programmable devices for biomedicine. I will describe new bioinspired nanotechnologies, including a fluid Shear-Activated Nanotherapeutic delivery system that targets drugs specifically to vascular occlusion sites.