Nathanson Laboratory--Publications

Dept of

Laszlo, GS, Rosoff, ML, Amieux, PS, and Nathanson, NM. (2006) Multiple promoter elements required for Leukemia Inhibitory Factor-stimulated M2 muscarinic acetylcholine receptor promoter activity. J. Neurochem. 98.1302-1315.

Abrams, P, Andersson, KE, Bucafusco, J, Chapple, C, de Groat, WC, Fryer, A, Kay, G, Laties, A, Nathanson, NM, Pasricha, J, and Wein, A. (2006) Muscarinic receptors: their distribution and function in body systems and the implications for treating overactive bladder. Brit. J. Pharmacol. 148.565-578.

Goin JC, Nathanson NM. (2005) Quantitative analysis of homo- and heterodimerization of muscarinic acetylcholine receptors in live cells: regulation of receptor down-regulation by heterodimerization. J Biol Chem. [Epub ahead of print]

Zhang Y, Hamilton SE, Nathanson NM, Yan J. (2005) Decreased Input-Specific Plasticity of the Auditory Cortex in Mice Lacking M1 Muscarinic Acetylcholine Receptors. Cereb Cortex. [Epub ahead of print]

Shen W, Hamilton SE, Nathanson NM, Surmeier DJ. (2005) Cholinergic suppression of KCNQ channel currents enhances excitability of striatal medium spiny neurons. J Neurosci. 25(32):7449-58.

Gibson RM, Laszlo GS, Nathanson NM. (2005) Calmodulin-dependent protein kinases phosphorylate gp130 at the serine-based dileucine internalization motif. Biochim Biophys Acta. 1714(1):56-62.

Iverson HA, Fox D 3rd, Nadler LS, Klevit RE, Nathanson NM. (2005) Identification and structural determination of the M(3) muscarinic acetylcholine receptor basolateral sorting signal. J Biol Chem. 280(26):24568-75. Epub 2005 May 2.

Zhang Y, Dyck RH, Hamilton SE, Nathanson NM, Yan J. (2005) Disrupted tonotopy of the auditory cortex in mice lacking M1 muscarinic acetylcholine receptor. Hear Res. 201(1-2):145-55.

Laszlo, G., and Nathanson, N.M. (2003) Src family kinase-independent signal transduction and gene induction by leukemia inhibitory factor. J Biol Chem 278(30): 27750-27757.

Nathanson, N.M (2003) An array of details on G-protein coupled receptor signaling: differential effects of a1 -adrenergic receptor subtypes on gene expression and cytokine receptor signaling. Molec Pharmacol 63(5): 959-960.

Anagnostaras, S.G., Murphy, G.G., Hamilton, S.E., Mitchell S.L., Rahnama, N.P., Nathanson, N.M., and Silva, A.J. (2003) Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nature Neurosci 6(1): 51-58.

Bymaster, F.P., Carter, P.A., Yamada, M., Gomeza, J., Wess, J., Hamilton, S.H., Nathanson, N.M., McKinzie, D., and Felder, C.C. (2003) Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur J Neurosci 17(7): 1403-1410.

Bartoe, J.L., and Nathanson, N.M. (2002) The independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor. Molec Brain Res 107(2): 108-119.

Goin, J.C., and Nathanson, N.M. (2002) Subtype-specific regulation of the expression and function of muscarinic acetylcholine receptors in embryonic chicken retinal cell. J Neurochem 83(4): 964-972.

Hardouin, S.N., Richmond, KN., Zimmermann, A., Hamilton, S.E., Feigl, E.O., and Nathanson, N.M. (2002) Altered cardiovascular responses in M1 muscarinic receptor knockout mice. J Pharmacol Exp Ther 301(1): 129-137.

Berkeley, J.L., Gomeza, J., Wess, J., Hamilton, S.E., Nathanson, N.M., and Levey, A.I. (2001) M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices. Molec Cell Neurosci 18(5): 512-524.

Hamilton, S.E., and Nathanson, N.M. (2001) The M1 receptor is required for muscarinic activation of MAP kinase in cortical neurons. J Biol Chem 276(19): 15850-15853.

Nadler, L.S., and Nathanson, N.M. (2001) Identification of a basolateral sorting signal for the M3 muscarinic acetylcholine receptor in Madin-Darby Canine Kidney cells. J Biol Chem 276(13): 10539-10547.

Birdsall, N.J.M., Nathanson, N.M., and Schwarz, R.D. (2001) Muscarinic receptors: it's a knockout. Trends in Pharmacol Sci 22: 215-219.

Belmonte, K.E., McKinnon, L.A., and Nathanson, N.M. (2000) Developmental expression of muscarinic acetylcholine receptors in chick retina: selective induction of M2 muscarinic receptor expression in ovo by a factor secreted by muller glial cells. J Neurosci 20(22): 8417-8425.

Gibson, R.M., Schiemann, W.P., Pritchard, L.B., Reno, J.M., Ericsson, L.H., and Nathanson, N.M. (2000) Phosphorylation of human gp130 at Ser782 adjacent to the di-leucine internalization motif: Effects on expression and signaling. J Biol Chem 275(29): 22574-22582.

Schlador, M.L., Grubbs, R., and Nathanson, N.M. (2000) Multiple topological domains mediate subtype-specific internalization of the M2 muscarinic acetylcholine receptor. J Biol Chem 275(30): 23295-23302.

Nathanson, N.M. (2000) A multiplicity of muscarinic mechanisms: enough signaling pathways to take your breath away. Proc Natl Acad Sci USA 97(12): 6245-6247.

Bartoe, J.L., and Nathanson, N.M. (2000) Differential regulation of LIF-stimulated neuronal gene expression by phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways. J Neurochem 74(5): 2021-2032.

Creason, S., Tietje, K.M., and Nathanson, N.M. (2000) Isolation and functional characterization of the chick M5 muscarinic acetylcholine receptor gene. J Neurochem 74(2): 882-885.

Rouse, S.T., Hamilton, S.E., Potter, L.T., Nathanson, N.M., and Conn, P.J. (2000) Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors. Neurosci Lett 278(1-2): 61-64.

Nadler LS, Kumar G, Hinds TR, Migeon JC, and Nathanson NM. (1999) Assymetric distribution of muscarinic acetylcholine receptors in Madin Darby Canine Kidney cells. Amer J Physiol 277(6 Pt 1): C1220-1228.

Shapiro, M.S., Loose, M.D., Hamilton, S.E., Nathanson, N.M., Gomeze, J., Wess, J., and Hille, B. (1999) Assignment of muscarinic receptor subtypes mediating G-protein modulation of Ca2+ channels using knockout mice. Proc Natl Acad Sci USA 96(19): 10899-10904.

Rosoff ML and Nathanson NM. (1999) Tyrosines 905 and 915 of gp130 are required for maximum induction of m2 muscarinic acetylcholine receptor and VIP gene transcription by cytokines in neuronal cells. Cell Mol Neurobiol 19(2): 289-296.

Schiemann WP and Nathanson NM. (1998) Raf-1 independent stimulation of mitogen-activated protein kinase by leukemia inhibitory factor in 3T3-L1 cells. Oncogene 16(20): 2671-2679.

Rosoff ML and Nathanson NM. (1998) GATA factor-dependent regulation of cardiac m2 muscarinic acetylcholine gene transcription. J Biol Chem 273(15): 9124-9129.

Fischer AJ, McKinnon LA, Nathanson NM, and Stell WK. (1998) Identification and localization of muscarinic acetylcholine receptors in the ocular tissues of the chick. J Comp Neurol 392(3): 273-284.

McKinnon LA, Gunther EC, and Nathanson NM. (1998) Developmental regulation of the cm2 muscarinic acetylcholine receptor gene: selective induction by a secreted factor produced by embryonic chick retinal cells. J Neurosci 18(1): 59-69.

Hamilton SE, Loose MD, Qi M, Levey AI, Hille B, McKnight GS, Idzerda RL, and Nathanson NM. (1997) Disruption of the m1 receptor gene ablates muscarinic receptor-dependent M current regulation and seizure ativity in mice. Proc Natl Acad Sci USA 94(24): 13311-13316.

Thomas SL, Chmelar RS, Lu C, Halvorsen SW, and Nathanson NM. (1997) Tissue-specific regulation of G-protein-coupled inwardly rectifying K+ channel expression by muscarinic receptor activation in ovo. J Biol Chem 272(47): 29958-29962.

Jackson DA and Nathanson NM. (1997) Regulation of expression and fucntion of m2 and m4 muscarinic receptors in cultured embryonic chick heart cells by transforming growth factor-beta 1. Biochem Pharmacol 54(4): 525-527.

Schlador ML and Nathanson NM. (1997) Synergistic regulation of m2 muscarinic acetylcholine receptor desensitization and sequestration by G protein-coupled receptor kinase-2 and beta-arrestin-1. J Biol Chem 272(30): 18882-18890.

Schiemann WP, Bartoe JL, and Nathanson NM. (1997) Box 3-independent signaling mechanisms are involved in leukemia inhibitory factor receptor alpha- and gp130-mediated stimulation of mitogen-activated protein kinase. Evidence for participation of multiple signaling pathways which converge at Ras. J Biol Chem 272(26): 16631-16636.

Hamilton SE and Nathanson NM. (1997) Differential localization of G-proteins, G alpha o and G alpha i-1, -2, and -3, in polarized epithelial MDCK cells. Biochem Biophys Res Commun 234(1): 1-7.

Rosoff ML, Wei J, and Nathanson NM. (1996) Isolation and characterization of the chicken m2 acetylcholine receptor promotor region: induction of gene transcription by leukemia inhibitory factor and ciliary neurotrophic factor. Proc Natl Acad Sci USA 93(25): 14889-14894.

Goldman PS, Schlador ML, Shapiro RA, and Nathanson NM. (1996) Identification of a region required for subtype-specific agonist-induced sequestration of the m2 muscarinic acetylcholine receptor. J Biol Chem 271(8): 4215-4222.


Nathanson NM. (1996) Regulation of muscarinic acetylcholine receptor expression and function. Prog Brain Res 109: 165-168.


Hamilton SE, McKinnon LA, Jackson DA, Goldman PS, Migeon JC, Habecker BA, Thomas SL, and Nathanson NM. (1995) Molecular analysis of the regulation of muscarinic receptor expression and function. Life Sci 56(11-12): 939-43.


Jackson DA and Nathanson NM. (1995) Subtype-specific regulation of muscarinic receptor expression and function by heterologous receptor activation. J Biol Chem 270(38): 22374-22377.


McKinnon LA and Nathanson NM. (1995) Tissue-specific regulation of muscarinic acetylcholine receptor expression during embryonic development. J Biol Chem 270(35): 20636-20642.


Migeon JC, Thomas SL, and Nathanson, NM. (1995) Differenctial coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G(o) alpha subunits. J Biol Chem 270(27): 16070-16074.


Schiemann WP, Graves LM, Baumann H, Morella KK, Gearing DP, Nielsen MD, Krebs EG, and Nathanson NM. (1995) Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activiation. Proc Natl Acad Sci USA 92(12): 5361-5365.

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