Dr. Studholme's research is focused on mathematical and computational techniques to study brain anatomy and its change over time, with a particular focus on fetal and premature neonatal brain growth. His research group, the Biomedical Image Computing Group, is working on new techniques to solve the problem of how to produce images of the human fetal head in utero—which is especially challenging because the fetal head is often moving. Dr. Studholme's group uses magnetic resonance imaging (MRI) to solve this problem and provide the first high-resolution 3D images of early human brain growth. As part of this project, his group has developed a 4-dimensional computational map of tissue volume changes and surface shape changes that occur when the human brain surface begins to fold, in a process that will go on to form the complex anatomy of the adult human brain. In recent papers, Studholme's team has mapped the points at which the first differences in the left and right sides of the brain emerge in the developing fetus, and the team has developed techniques to accurately compare brain anatomy in premature babies to that of normally developing fetuses.