EDUCATION AND TRAINING
Nephrology Fellowship (1999-2003)
University of Washington
Seattle, WA
Chief Resident of Medicine (1999)
West Roxbury VA Hospital
West Roxbury, MA
Medicine Residency (1996-99)
Beth Israel Hospital
Boston, MA
Medical School (1992-96)
McGill University
Montreal, Quebec
Canada
SITE OF PRACTICE:
University of Washington Medical Center
CONTACT INFORMATION
University of Washington
Medical Center
1959 N.E. Pacific Street, BOX
356521
Seattle, WA 98195
Phone: (206) 543-2346
Fax: (206) 685-8661
Email:
rdrvsula@u.washington.edu
Administrative Contacts:
http://depts.washington.edu/
nephron/admin.htm |
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Raghu
Durvasula, M.D.
Assistant Professor of
Medicine
CLINICAL INTERESTS
- Pathogenesis and
treatment of glomerular disease
- Progression of
chronic kidney disease
RESEARCH INTERESTS
- Podocyte
injury in states of glomerular capillary hypertension
- Intra-renal
renin-agiotensin system and progression of glomerular disease
- Pleiotropic
effects of statins in podocyte disease
- Experimental
models of glomerular disease
CURRENT RESEARCH:
- Effects of
mechanical strain in mediating podocyte detachment through
upregulation of the matricellular protein SPARC
- Activation
of a local angiotensin system in podocytes as a result of the diabetic
milieu
- Effects
of rosuvostatin as a pro-survival factor for podocytes
- Establishing
the podocyte as a direct target of glucocorticoid signaling
- Identifying
B cell linker protein as a novel constituent of the slit diaphragm
assembly
SELECTED
PUBLICATIONS
Durvasula R,
Shankland, S. The Renin-angiotensin System in Glomerular Podocytes:
Mediator of Glomerulosclerosis and Link to Hypertensive Nephropathy
Current Hypertension reports. 8:132-8, 2006
Durvasula R,
Shankland S. Podocyte injury and targeting therapy: An update. Current
Opinions in Nephrology and Hypertension 15:1-7, 2006
Durvasula R,
Shankland S. Mechanical strain increases SPARC levels in podocytes:
Implications for glomerulosclerosis. American Journal of Physiology
Renal Physiology.289:F577-84, 2005
Durvasula RV,
Petermann AT, Hiromura K, Blonski M,
Pippin JW, Mundel P, Pichler R, Griffin S, Couser WG, Shankland SJ.
Activation of a local tissue angiotensin system in podocytes by
mechanical strain. Kidney International 65: 1-10, 2004.
Durvasula R,
Shankland, S. Models of renal disease: Models of Glomerulonephritis,
Methods in Molecular Medicine 86: 47-66, 2003.
AWARDS
-
NIH/NIDDK KO-8 Mentored Career
Development Award (07/2003-06/2008); project title: “Stretch Induced
Podocyte injury – Role in Glomerulosclerosis.”
-
DERC Pilot and Feasibility Award
08/2004 – 07/2007; project title: “Role of Angiotensin in mediating
podocyte injury in diabetic nephropathy.”
-
Astra Zeneca Investigator Initiated
Study 08/2005 – 07/2007; project title: “Role of rosuvastatin in
preventing podocyte injury: Implications for the stabilization of
progressive renal insufficiency.”
-
American Heart Association Beginner
Grant-In-Aid Award (07/2007 – 06/2009); project title: “The Role of
BLNK in Modulating Podocyte Response Following Injury.”
-
First prize, Outstanding Basic Science
Research, 2003: Awarded at the Nephrology Young Investigators’ Forum
hosted by the National Kidney Foundation of Northern California, San
Francisco, CA (abstract
entitled “Activation of a local
tissue angiotensin system in podocytes by mechanical strain.”)
-
Pfizer Inc. “Outstanding Abstract
Award” for Nephrology Fellows Program at the American Society of
Nephrology Annual Meeting 2001, San Francisco, CA (abstract entitled,
“Upregulation of SPARC and TGF-beta by mechanical stretch in cultured
mouse podocytes.”)
PROFESSIONAL
RESPONSIBILITIES:
- Moderator and
Abstract Reviewer, American Society of Nephrology Meetings, 2005-07
- Invited speaker,
Podocyte Signaling Symposium, American Society of Nephrology Meetings,
2007
- Ad hoc reviewer,
Kidney International, Journal of the American Society of Nephrology,
Hypertension, 2003-present
- Grant Reviewer
for National Medical Research Council, Singapore, 2006
- Member,
Northwest Renal Society, 2000-present
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