Investigators - Clinical/Translational - de boer

Ian de Boer, MD, MS

Project 1: SUGAR: Study of glucose and insulin in renal disease

The overall goals of this patient-oriented research study are to define insulin resistance in moderate-severe CKD, including its severity, its relationships with beta-cell function and glucose tolerance, methods of quantitative assessment for use in future epidmiologic studies and clinical trials, and associations with endothelial function, arterial stiffness, oxidative stress, and inflammation.

Observational study enrolling human subjects: University of Washington
Contact: Laura Curtin, 221-3938, now enrolling

Project 2: Vitamin D catabolism in chronic kidney disease

This project will define vitamin D catabolism and its health impact in chronic kidney disease using synergistic patient-oriented and epidemiologic studies.

Observational study enrolling human subjects: University of Washington
Contact: Laura Curtin, 221-3938, enrollment to begin in 2015

Project 3: Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease

This study will test effects of cholecalciferol and omega-3 fatty acid supplementation on albuminuria and glomerular filtration rate as an ancillary study to the NIH-funded Vitamin D and Omega-3 Trial (VITAL)

Clinical Trial: University of Washington
Contact: Fully enrolled

Project 4: Phosphorous & Vitamin D in the MESA Cohort

The overall goal of this epidemiologic study is to define relationships of phosphorous excess and vitamin D insufficiency with pathophysiologically relevant clinical and subclinical cardiovascular disease outcomes in a community based, multi-ethnic population.

Current Funding

R01 DK087726 (de Boer, PI)
NIH, NIDDK (8/15/10-7/31/15)
Insulin resistance in chronic kidney disease

R01 DK099199 (de Boer, PI)
NIH, NIDDK (4/15/14-2/28/19)
Vitamin D catabolism in chronic kidney disease

R01 DK008762 (de Boer, PI)
NIH (9/1/10-8/31/15)
Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease

R01 HL111375 (Hoofnagle, PI; de Boer, Co-Investigator)
NIH, National Heart, Lung, and Blood Institute
HDL and cardiovascular risk in chronic kidney disease

R01 GM63666 (Thummel, P; de Boer, Co-Investigator)
NIH, NIGMS (07/01/014 – 06/30/18)
Hormonal Regulation of Human CYP3A

R01 DK102134-01 (Young, PI; de Boer, Co-Investigator)
NIH, NIDDK 9/20/13-8/31/16
CKD-Targeted Analyses of the Jackson Heart Study

UL1 TR000423 (Disis, PI; de Boer, Role: KL2 Career Development Program Co-Director)
NIH, National Center for Advancing Translational Science
Insulin resistance in chronic kidney disease

JDRF 17-2013-9 (Paterson, PI; de Boer, Co-Investigator)
Junvenile Diabetes Research Fund
Genetics of the decline in glomerular filtration rate in Type 1 diabetes

Past Funding

RC4 DK090766 (de Boer, PI)
NIH (9/30/10-9/29/12)
Vitamin D metabolism and type 1 diabetes complications

ExtenD investigator-initiated grant (de Boer, PI)
Abbott Laboratories (7/1/09-6/30/11)
Effects of paricalcitol on glucose tolerance, immune cell function, and oxidative stress in stage 3-4 chronic kidney disease

KL2 RR025015 (Disis, PI; Role: Clinical Research Scholar)
NIH/NCRR (9/17/07-6/30/11)

Pilot & Feasibility Award (de Boer, PI)
UW DERC (NIH/NIDDK) (7/1/07-6/30/10)
Pilot clinical trial of vitamin D3 in the metabolic syndrome

Current Research Members

Laura Curtin: Research Coordinator

Connor Henry: Research Assistant

Nicole Robinson: Research Assistant

Leila Zelnick: Biostatistician

Publications

PubMed provides a list of Dr. De Boer's research publications

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