Investigators - Clinical/Translational - de boer
Ian de Boer, MD, MS
Project 1: Randomized clinical trial of vitamin D3 in diabetic kidney disease
This placebo-controlled proof-of-concept clinical trial test whether cholecalciferol (vitamin D3) is safe, effectively raises serum 25-hydroxyvitamin D concentrations, and reduces albuminuria and other markers of cardiovascular risk among participants with type 2 diabetes and microalbuminuria.
Clinical Trial: University of Washington
Contact: Alexandra Flynn, 221-3938
Project 2: Metabolic effects of paricalcitol
This placebo-controlled cross-over clinical trial tests effects of the active vitamin D analogue paricalcitol on glucose tolerance, immune cell function, and oxidative stress in non-diabetic stage 3-4 chronic kidney disease.
Clinical Trial: University of Washington
Contact: Laura Curtin, 221-3938
Project 3: Phosphorous & Vitamin D in the MESA Cohort
The overall goal of this epidemiologic study is to define relationships of phosphorous excess and vitamin D insufficiency with pathophysiologically relevant clinical and subclinical cardiovascular disease outcomes in a community based, multi-ethnic population.
Project 4: SUGAR: Study of glucose and insulin in renal disease
The overall goals of this patient-oriented research study are to define insulin resistance in moderate-severe CKD, including its severity, its relationships with beta-cell function and glucose tolerance, methods of quantitative assessment for use in future epidmiologic studies and clinical trials, and associations with endothelial function, arterial stiffness, oxidative stress, and inflammation.
Clinical Trial: University of Washington
Contact: Laura Curtin, 221-3938
Project 5: Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
This study will test effects of cholecalciferol and omega-3 fatty acid supplementation on albuminaria and glomerular filtration rate as an ancillary study to the NIH-funded Vitamin D and Omega-3 Trial (VITAL)
Project 6: Vitamin D and type 1 diabetes complications
This study will test associations of novel biomarkers of Vitamin D metabolism with teh development of kidney and cardiovascular disease in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Study (DCCT/EDIC)
Current Funding
R01 HL096875 (de Boer, Kestenbaum, multiple PI)
NIH (4/1/10-3/31/14)
Phosphorous and vitamin D metabolism and cardiovascular outcomes: the multi-ethnic study of atherosclerosis
R01 DK008762 (de Boer, PI)
NIH (9/1/10-8/31/15)
Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
R01 DK087726 (de Boer, PI)
NIH (8/15/10-7/31/14)
Insulin resistance in chronic kidney disease
RC4 DK090766 (de Boer, PI)
NIH (9/30/10-9/29/12)
Vitamin D metabolism and type 1 diabetes complications
R01 HL094555 (Mukamal, Djousse, Ix, Kizer, Zieman, PIs; Role: Co-investigator)
NIH/NIHLBI (7/1/09-6/30/13)
Determinants and Consequences of Diabetes in Older Adults
ExtenD investigator-initiated grant (de Boer, PI)
Abbott Laboratories (7/1/09-6/30/11)
Effects of paricalcitol on glucose tolerance, immune cell function, and oxidative stress in stage 3-4 chronic kidney disease
Past Funding
KL2 RR025015 (Disis, PI; Role: Clinical Research Scholar)
NIH/NCRR (9/17/07-6/30/11)
Pilot & Feasibility Award (de Boer, PI)
UW DERC (NIH/NIDDK) (7/1/07-6/30/10)
Pilot clinical trial of vitamin D3 in the metabolic syndrome
Current Research Members
Cortney Bosworth, MD: Renal Fellow
Laura Curtin: Research Coordinator
Aparna Laksman: Research Assistant
Micahel Sachs, PhD: Biostatistician
Publications
PubMed provides a list of Dr. De Boer's research publications