Investigators - Clinical/Translational - de boer

Ian de Boer, MD, MS

Project 1: SUGAR: Study of glucose and insulin in renal disease

The overall goals of this patient-oriented research study are to define insulin resistance in moderate-severe CKD, including its severity, its relationships with beta-cell function and glucose tolerance, methods of quantitative assessment for use in future epidmiologic studies and clinical trials, and associations with endothelial function, arterial stiffness, oxidative stress, and inflammation.

Clinical Trial: University of Washington
Contact: Laura Curtin, 221-3938

Project 2: Phosphorous & Vitamin D in the MESA Cohort

The overall goal of this epidemiologic study is to define relationships of phosphorous excess and vitamin D insufficiency with pathophysiologically relevant clinical and subclinical cardiovascular disease outcomes in a community based, multi-ethnic population.

Project 3: Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease

This study will test effects of cholecalciferol and omega-3 fatty acid supplementation on albuminuria and glomerular filtration rate as an ancillary study to the NIH-funded Vitamin D and Omega-3 Trial (VITAL)

Clinical Trial: University of Washington
Contact: Fully enrolled

Project 4: Metabolic effects of paricalcitol

This placebo-controlled cross-over clinical trial tests effects of the active vitamin D analogue paricalcitol on glucose tolerance, immune cell function, and oxidative stress in non-diabetic stage 3-4 chronic kidney disease.

Clinical Trial: University of Washington
Contact: Fully enrolled

Project 5: Continuous glucose monitoring to assess glycemia in chronic kidney disease

The goal of this patient-oriented research study is to describe the extent of glucose variability, incidence rates and severity of hypoglycemia, the performance of biomarkers evaluating hyperglycemia, and the biologic sequelae of impaired glucose regulation in those with advanced diabetic kidney disease using a state-of-the-art continuous glucose monitoring system.

Current Funding

R01 HL096875 (de Boer, Kestenbaum, multiple PI)
NIH (4/1/10-3/31/14)
Phosphorous and vitamin D metabolism and cardiovascular outcomes: the multi-ethnic study of atherosclerosis

R01 DK008762 (de Boer, PI)
NIH (9/1/10-8/31/15)
Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease

R01 DK087726 (de Boer, PI)
NIH (8/15/10-7/31/14)
Insulin resistance in chronic kidney disease

UL1 TR000423 (Disis, PI; de Boer, Role: KL2 Career Development Program Co-Director)
NIH, National Center for Advancing Translational Science
Insulin resistance in chronic kidney disease

R01 HL111375 (Hoofnagle, PI; de Boer, Co-Investigator)
NIH, National Heart, Lung, and Blood Institute
HDL and cardiovascular risk in chronic kidney disease

JDRF 17-2013-9 (Paterson, PI; de Boer, Co-Investigator)
Junvenile Diabetes Research Fund
Genetics of the decline in glomerular filtration rate in Type 1 diabetes

Past Funding

RC4 DK090766 (de Boer, PI)
NIH (9/30/10-9/29/12)
Vitamin D metabolism and type 1 diabetes complications

ExtenD investigator-initiated grant (de Boer, PI)
Abbott Laboratories (7/1/09-6/30/11)
Effects of paricalcitol on glucose tolerance, immune cell function, and oxidative stress in stage 3-4 chronic kidney disease

KL2 RR025015 (Disis, PI; Role: Clinical Research Scholar)
NIH/NCRR (9/17/07-6/30/11)

Pilot & Feasibility Award (de Boer, PI)
UW DERC (NIH/NIDDK) (7/1/07-6/30/10)
Pilot clinical trial of vitamin D3 in the metabolic syndrome

Current Research Members

Laura Curtin: Research Coordinator

Cassiane Robinson-Cohen, PhD: Epidemiologist

Publications

PubMed provides a list of Dr. De Boer's research publications

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