Investigators - Clinical/Translational - himmelfarb

Jonathan Himmelfarb, MD

Project 1: Vascular Structure and Function in Arteriovenous Fistula Maturation

The central hypothesis of this proposal is that uremia-related functional and structural alterations in the vasculature can be identified which will predict the probability of AV fistula maturation.

Project 2: Genetic Determinants of Outcomes of Acute Kidney Injury

The central hypotheses are that genetic factors can be identified which predispose to the development of AKI, influence survival and recovery of kidney function after the development of AKI, and impact long-term risk for ESRD in survivors of AKI.

Project 3: Novel biomarker validation and dosing algorithms for anemia management in ESRD

The central hypothesis is that specific serum proteins and peptides are candidate surrogate biomarkers for EPO responsiveness and can be used to improve existing algorithms for predictive EPO response indexing.

Project 4: A Tissue Engineered Human Kidney Microphysiological System

The goal of this proposal is to develop a model system that predicts drug excretion by the human kidney, emulating healthy and disease related conditions, using an in vitro 3-dimensional modular microphysiological system with human kidney-derived cells.

Project 5: HDL and cardiovascular risk in chronic kidney disease

The goal of this proposal is to establish the HDL proteomic changes in subjects with CKD and how they are associated with endothelial dysfunction in vitro and in vivo.

Project 6: Mechanisms of Arterial Graft Healing

The central  hypothesis is that the p27Kip1-838AA genotype is associated with long term patency after arteriovenous fistula and graft creation for dialysis access.

Project 7: Endothelial Dysfunction, Nitric Oxide, and Renal Failure

The central hypothesis is that administration of glutamine can improve endothelial function in subjects with moderate to severe chronic kidney disease by bypassing the metabolic block on mitochondrial oxidative phosphorylation (Warburg effect.)

Project 8: Longitudinal US Canadian Study of Incident Dialysis (LUCID)

The LUCID study is a large prospective observational study of patients commencing dialysis in United States (Boston, Seattle) and Canada (Vancouver, Calgary, Edmonton, Ottawa, and Toronto). This study collects research-quality information on risk factors and outcomes from an ethnically heterogeneous population of dialysis patients and stores specimens (blood and urine) obtained at baseline and during long-term follow-up.

Current Funding

U01 DK 082179 (Himmelfarb, PI)
NIH/NIDDK (7/1/08-6/30/15)
“Vascular Structure and Function in Arteriovenous Fistula Maturation”   The central hypothesis of this proposal is that uremia-related functional and structural alterations in the vasculature can be identified which will predict the probability of AV fistula maturation.

U01 DK084012-01(Himmelfarb, PI)
NIH/NIDDK (9/1/10-8/31/15)
Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease

R01 DK087726 (de Boer, PI)
NIH (7/1/2010-6/30/15)
“Genetic Determinants of Outcomes of Acute Kidney Injury” The central hypotheses are that genetic factors can be identified which predispose to the development of AKI, influence survival and recovery of kidney function after the development of AKI, and impact long-term risk for ESRD in survivors of AKI.

R01 DK091584 (Merchant, PI. Himmelfarb, Co- I)
NIH/NIDDK (9/20/11 – 8/31/15)
"Novel biomarker validation and dosing algorithms for anemia management in ESRD .The central hypothesis is that specific serum proteins and peptides are candidate surrogate biomarkers for EPO responsiveness and can be used to improve existing algorithms for predictive EPO response indexing.

UH2/UH3 TR000504 (Himmelfarb, PI)
NIH/NCATS (7/24/12-6/1/17)
“A Tissue Engineered Human Kidney Microphysiological System.” The goal of this proposal is to develop a model system that predicts drug excretion by the human kidney, emulating healthy and disease related conditions, using an in vitro 3-dimensional modular microphysiological system with human kidney-derived cells

Canadian Institute of Health Research (Tonelli PI, Himmelfarb Co-I)
(7/01/12-6/30/16)
“Longitudinal US Canadian Study of Incident Dialysis (LUCID)” The LUCID study is a large prospective observational study of patients commencing dialysis in United States and Canada .

RO1 DK045462 (Goligorsky PI, Himmelfarb, Co-I)
NIH/NIDDK (9/01/11 – 4/30/15)
“Endothelial Dysfunction, Nitric Oxide, and Renal Failure” The central hypothesis is that administration of glutamine can improve endothelial function in subjects with moderate to severe chronic kidney disease by bypassing the metabolic block on mitochondrial oxidative phosphorylation (Warburg effect.)

RO1 HL111375 (Hoofnagle PI, Himmelfarb Co-I)
NIH/NHLBI (7/01/12-6/30/16)
“HDL and cardiovascular risk in chronic kidney disease” The goal of this proposal is to establish the HDL proteomic changes in CKD and how they are associated with endothelial dysfunction in vitro and in vivo.

UO1 DK099923 (Himmelfarb, Co-PI)
NIH/NIDDK (9/15/13- 6/30/18)
“Anti-Inflammatory Interventions in Maintenance Hemodialysis Patients” The goal of this proposal is to test anti-inflammatory agents in pilot clinical trials in patients undergoing hemodialysis.

Recently Completed Funding

R01 HL 065 193-08 (Ikizler, PI, Himmelfarb, Co-I)
NIH (7/1/09-6/30/13)
“Genes and Fibrinolytic Capacity of Human Endothelium”
This proposal is designed to test the hypothesis that bradykinin-stimulated inflammation contributes to the cardiovascular event risk in patients undergoing hemodialysis. This study is in no cost extension.

2R01HL070938- (Himmelfarb, Co-PI) 
NIH/NHLBI (9/05/09-5/31/13)
"Oxidative Stress in Chronic Kidney Disease"
This proposal seeks to assess the importance of diet, exercise and physical functioning on surrogate markers of cardiovascular risk in stage 3 CKD, including oxidative stress, inflammation and endothelial dysfunction. This study is in no cost extension.

Current Research Members

Please visit the Kidney Research Website for Dr. Himmelfarb's Investigators

Publications

PubMed provides a list of Dr. Himmelfarb's research publications

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