Investigators - Clinical/Translational - kestenbaum
Bryan Kestenbaum, MD, MS
Project 1: Mineral metabolism disturbances and arteriovenous fistula maturation
This project is determining the role of mineral metabolism disturbances in arteriovenous fistula maturation in a multi-site study of end stage renal disease patients.
Project 2: Mineral metabolism and cardiovascular outcomes
This project is evaluating serum, urine, and genetic markers of mineral metabolism in association with cardiovascular disease outcomes in the Multi-Ethnic Study of Atherosclerosis.
Project 3: Markers of proximal tubule secretion
This project is quantifying renal proximal tubule secretion function from specific serologic and urine markers and determining associations with kidney disease progression and cardiovascular outcomes.
Project 4: Skeletal muscle dysfunction in chronic kidney disease
This project is measuring skeletal muscle mitochondrial oxidative phosphorylation and coupling capacity in chronic kidney disease patients using magnetic resonance spectroscopy and optical spectroscopy.
Project 5: Insulin resistance in chronic kidney disease
This project is characterizing insulin sensitivity, beta-cell function, and glucose tolerance using gold-standard methods among individuals who have moderate-severe chronic kidney disease.
Project 6: CKD targeted analyses of the Jackson Heart Study
This project is determining novel and traditional risk factors for kidney disease progression and cardiovascular complications of kidney disease among African Americans in the Jackson Heart Study.
R01 DK094891-01 (Kestenbaum, PI)
NIH/NIDDK (09/01/2012 – 08/31/2015)
Mineral Metabolism disturbances and arteriovenous fistula maturation
R21-DK081315-01A2 (Kestenbaum, PI)
NIH/NIDDK (07/01/2011 – 08/31/2014)
Serum calcification activity in patients with chronic kidney disease
R01 DK087726 (de Boer, PI)
Insulin resistance in chronic kidney disease
R01 DK102134 (Young, PI)
NIH/NHLBI (09/01/2013 – 08/31/2016)
CKD targeted analyses of the Jackson Heart Study
R01DK094434 (Rosenfeld, PI)
NIH/NIDDK (08/01/2012 – 06/30/2017)
RANK-RANKL and vascular complications in chronic kidney disease
A74915 (Giachelli, PI)
Daiichi Sankyo Pharmaceuticals Inc. (05/01/2012 – 04/30/2014)
Candidate vascular calcification genes in human smooth muscle tissue
R01 HL096875 (Kestenbaum, de Boer, Co- PIs)
NIH/NHLBI (04/01/2010 – 06/30/2014)
Phosphorous, vitamin D, and cardiovascular outcomes
R01HL084443 (Kestenbaum, PI)
NIH/NHLBI (09/01/2007 – 05/31/2011)
Mineral Metabolism and Cardiovascular Risk among Older Adults
NIH/ARRA (Kestenbaum, PI)
(09/01/2009 – 05/31/2011)
Administrative supplement to Mineral Metabolism and Cardiovascular Risk
K23DK63274 (Kestenbaum, PI)
NIH/NIDDK (04/01/2003 – 03/31/2008)
Cardiac outcomes associated with renal osteodystrophy
Northwest Kidney Centers (Kestenbaum, PI)
The Seattle Kidney Study
Amgen Corp (Kestenbaum, PI)
(03/01/2004 - 08/31/2005)
Hip fracture rates among U.S. dialysis patients
Genzyme Corp (Kestenbaum, PI)
(01/01/2003 - 12/31/2005)
Serum phosphate levels and mortality risk
Current Research Members
Christine Flogel, MD, MS:
Christine completed her Med/Peds Nephrology training at the University of Washington and Seattle Childrens Hospital. She completed her MS in Epidemiology at the University of Washington. Her research themes involve maternal risk factors for acute and chronic kidney disease and trials to prevents acute kidney injury in children.
Astrid Suchy-Dicey, MA:
Astrid is a PhD candidate in Epidemiology at the University of Washington. Her research themes involve the measurement of novel markers of kidney proximal tubule function using mass spectrometry and determining the relevance of proximal tubule function in chronic kidney disease.
Leila Zelnick, MS:
Leila is a PhD candidate in Biostatistics at the University of Washington. Her research themes involve the analysis of longitudinal measurements of kidney and cardiac biomarkers across multiple cohort studies.
PubMed provides a list of Dr. Kestenbaum's research publications