Investigators - Clinical/Translational - kestenbaum

Bryan Kestenbaum, MD, MS

Project 1: Mineral metabolism disturbances and arteriovenous fistula maturation

This project is determining the role of mineral metabolism disturbances in arteriovenous fistula maturation in a multi-site study of end stage renal disease patients.

Project 2: Mineral metabolism and cardiovascular outcomes

This project is evaluating serum, urine, and genetic markers of mineral metabolism in association with cardiovascular disease outcomes in the Multi-Ethnic Study of Atherosclerosis.

Project 3: Markers of proximal tubule secretion

This project is quantifying renal proximal tubule secretion function from specific serologic and urine markers and determining associations with kidney disease progression and cardiovascular outcomes.

Project 4: Skeletal muscle dysfunction in chronic kidney disease

This project is measuring skeletal muscle mitochondrial oxidative phosphorylation and coupling capacity in chronic kidney disease patients using magnetic resonance spectroscopy and optical spectroscopy.

Project 5: Insulin resistance in chronic kidney disease

This project is characterizing insulin sensitivity, beta-cell function, and glucose tolerance using gold-standard methods among individuals who have moderate-severe chronic kidney disease.

Project 6: CKD targeted analyses of the Jackson Heart Study

This project is determining novel and traditional risk factors for kidney disease progression and cardiovascular complications of kidney disease among African Americans in the Jackson Heart Study.

Current Funding

R01 DK094891-01 (Kestenbaum, PI)
NIH/NIDDK (09/01/2012 – 08/31/2015)
Mineral Metabolism disturbances and arteriovenous fistula maturation

R21-DK081315-01A2 (Kestenbaum, PI)
NIH/NIDDK (07/01/2011 – 08/31/2014)
Serum calcification activity in patients with chronic kidney disease

R01 DK087726 (de Boer, PI)
NIH/NIDDK (8/15/10-7/31/14)
Insulin resistance in chronic kidney disease

R01 DK102134 (Young, PI)
NIH/NHLBI (09/01/2013 – 08/31/2016)
CKD targeted analyses of the Jackson Heart Study

R01DK094434 (Rosenfeld, PI)
NIH/NIDDK (08/01/2012 – 06/30/2017)
RANK-RANKL and vascular complications in chronic kidney disease

A74915 (Giachelli, PI)
Daiichi Sankyo Pharmaceuticals Inc. (05/01/2012 – 04/30/2014)
Candidate vascular calcification genes in human smooth muscle tissue

Past Funding

R01 HL096875 (Kestenbaum, de Boer, Co- PIs)
NIH/NHLBI (04/01/2010 – 06/30/2014)
Phosphorous, vitamin D, and cardiovascular outcomes

R01HL084443 (Kestenbaum, PI)
NIH/NHLBI (09/01/2007 – 05/31/2011)
Mineral Metabolism and Cardiovascular Risk among Older Adults

NIH/ARRA (Kestenbaum, PI)
(09/01/2009 – 05/31/2011)
Administrative supplement to Mineral Metabolism and Cardiovascular Risk

K23DK63274 (Kestenbaum, PI)  
NIH/NIDDK (04/01/2003 – 03/31/2008)
Cardiac outcomes associated with renal osteodystrophy

Northwest Kidney Centers (Kestenbaum, PI)
(01/01/2006 –12/31/2008)
The Seattle Kidney Study

Amgen Corp (Kestenbaum, PI)
(03/01/2004 - 08/31/2005)
Hip fracture rates among U.S. dialysis patients

Genzyme Corp (Kestenbaum, PI)
(01/01/2003 - 12/31/2005)
Serum phosphate levels and mortality risk

Current Research Members

Christine Flogel, MD, MS:
Christine completed her Med/Peds Nephrology training at the University of Washington and Seattle Childrens Hospital. She completed her MS in Epidemiology at the University of Washington. Her research themes involve maternal risk factors for acute and chronic kidney disease and trials to prevents acute kidney injury in children.

Astrid Suchy-Dicey, MA:
Astrid is a PhD candidate in Epidemiology at the University of Washington. Her research themes involve the measurement of novel markers of kidney proximal tubule function using mass spectrometry and determining the relevance of proximal tubule function in chronic kidney disease.

Leila Zelnick, MS:
Leila is a PhD candidate in Biostatistics at the University of Washington. Her research themes involve the analysis of longitudinal measurements of kidney and cardiac biomarkers across multiple cohort studies.

Publications

PubMed provides a list of Dr. Kestenbaum's research publications

[top]