Investigators - Clinical/Translational - robinson-cohen

Cassianne Robinson-Cohen, PhD

Project 1: Physical Activity and Sedentary Behavior in Chronic Kidney Disease

This project aims to describe and quantify the prevalence, risk factors, and consequences of sedentarism in patients with chronic kidney disease.

Project 2: Patient-Reported Symptoms in Chronic Kidney Disease

The goals of this project are to 1) develop a practical chronic kidney disease symptom measurement tool with high construct validity and 2) identify circulating metabolites and retained uremic toxins that predict the degree of specific symptoms in CKD.

Project 3: Mineral Metabolism Disturbances, Race, and Cardiovascular Outcomes

Within this project, we are evaluating associations of mineral metabolism markers (e.g., parathyroid hormone, 24,25-dihydroxyvitamin D, fibroblast growth factor-23) with cardiovascular events in a large, community-based, multi-ethnic population of adults free of clinical cardiovascular disease at baseline. In particular, we are examining whether these associations vary by race.

Project 4: Genetic Variation and Mineral Metabolism Disturbances

The genetic underpinnings of the regulation of mineral metabolism markers (e.g., parathyroid hormone, 24,25-dihydroxyvitamin D, fibroblast growth factor-23) remain poorly understood. We are currently conducting several large genome wide association studies to investigate associations of common genetic variants with serum concentrations of these markers.

Current Funding

R01 HL096875 (Kestenbaum, de Boer, Co- PIs)
NIH/NHLBI 1 (04/01/2010 - 06/30/2013)
Phosphorous, vitamin D, and cardiovascular outcomes
This 4-year project evaluates a comprehensive panel of serum and urine markers of mineral metabolism in association with clinical and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis.

R01DK087726 (de Boer, PI)
NIH/NIDDK (07/01/2010 - 06/30/2014)
Insulin Resistance in chronic kidney disease
This 4-year project will comprehensively characterize insulin sensitivity, beta-cell function, and glucose tolerance using gold-standard methods among individuals who have moderate-severe chronic kidney disease.

Past Funding


NIH/NHLBI 1 R01HL084442 and NIH/ARRA (Kestenbaum, PI)
(09/01/2007 – 05/31/2011)
Mineral Metabolism and Cardiovascular Risk Among Older Adults” and administrative supplement
This 3-year project examined the association of serum markers of mineral metabolism with incidentncardiovascular events in the Cardiovascular Health Study

Northwest Kidney Centers (Kestenbaum, PI)
(01/01/2006 – 12/31/2008)
The Seattle Kidney Study
An ongoing prospective, observational clinic-basd study of chronic kidney disease in Seattle, Washington.

Publications

PubMed provides a list of Dr. Robinson-Cohen's research publications

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