Investigators - Clinical/Translational - Roshanravan

Baback Roshranravan, MD, MS, MSPH

Project 1: Skeletal muscle mitochondrial function is impaired in chronic kidney disease

CKD is associated with sarcopenia and impaired physical performance culminating in increased risk of disability and death. Skeletal muscle dysfunction is a devastating and underappreciated target-organ complication of CKD.  Here we compare skeletal muscle mitochondrial energetics using novel, non-invasive magnetic resonance spectroscopy among persons with moderate-severe CKD compared with healthy controls. We also investigate associations of mitochondrial dysfunction with insulin resistance.

Project 2: Creatinine Clearance and walking speed and muscle atrophy: a cohort study

Chronic kidney disease (CKD) is associated with malnutrition and inflammation. These processes may lead to loss of skeletal muscle and reduced physical performance. Associations of kidney function with muscle composition and longitudinal measures of physical performance are unknown. We are currently evaluating community-dwelling older adults enrolled in the InCHIANTI Study free of baseline stroke or ADL disability.  We are investigating the association of baseline renal function measured by 24 hour creatinine clearance with walking speed, calf muscle composition by CT at baseline. We are also investigating how lower renal function impacts changes in walking speed and knee strength over time.

Project 3: Lower eGFRcysc is associated with worse muscle fatigue and muscle quality among older adults

Little is known of the association of CKD with objective muscle fatigue and dynamic muscle impairment. In the current study we investigate the association of renal function with dynamic muscle function using isokinetic fatigue testing and assess the potential contribution of body composition in older adults. We are currently studying 1993 older adults enrolled in the Health, Aging and Body Composition Study who had isokinetic muscle fatigue testing and had kidney function measurement. DXA scans were performed to assess body composition. We estimated associations of GFRcysc with total knee extension work and fatigue and the potential contributions of body composition.

Project 4: A Randomized, Double-blind, Pilot Study of PINTA 745, an Anti-myostatin Peptibody, in Patients with End Stage Renal Disease who Require Maintenance Hemodialysis and have Protein Energy Wasting

This is a pilot study to assess the safety, pharmacokinetics and effectiveness of PINTA 745 or placebo in treating protein energy wasting (PEW) in patients receiving maintenance hemodialysis (MHD).

Project 5: Randomized controlled trial of glutamine in chronic kidney disease

This is a pilot study to test the impact of glutamine supplementation on skeletal muscle mitochondrial function using non-invasive magnetic resonance spectroscopy and optical spectroscopy among persons with CKD. W will also be testing if glutamine supplementation improves endothelial function. Secondary aims include investigating the effects of glutamine supplementation on metabolic response profile and albuminuria.

Current Funding

K23 DK099442-01
NIDDK (9/30/2013-9/30/2018)
Skeletal muscle dysfunction in persons with CKD

Past Funding

Metabolic Imaging Pilot Award
(3/2013 – June 30/2014)
Nutrition Obesity Research Center

1F32DK093235-01A1
NIDDK F32 (01/03/2013-9/30/2013)
Skeletal muscle function and mitochondrial metabolism in non-diabetic CKD

Publications

PubMed provides a list of Dr. Roshanravan's research publications

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