Clinical/patient Trials
University of Washington Medical Center
Project 1: Randomized clinical trial of vitamin D3 in diabetic kidney disease
This placebo-controlled proof-of-concept clinical trial test whether cholecalciferol (vitamin D3) is safe, effectively raises serum 25-hydroxyvitamin D concentrations, and reduces albuminuria and other markers of cardiovascular risk among participants with type 2 diabetes and microalbuminuria.
Principal Investigator: Ian de Boer, MD, MS
Trial Contact: Alexandra Flynn, 221-3938
Project 2: Metabolic effects of paricalcitol
This placebo-controlled cross-over clinical trial tests effects of the active vitamin D analogue paricalcitol on glucose tolerance, immune cell function, and oxidative stress in non-diabetic stage 3-4 chronic kidney disease.
Principal Investigator: Ian de Boer, MD, MS
Trial Contact: Laura Curtin, 221-3938
Project 3: SUGAR: Study of glucose and insulin in renal disease
The overall goals of this patient-oriented research study are to define insulin resistance in moderate-severe CKD, including its severity, its relationships with beta-cell function and glucose tolerance, methods of quantitative assessment for use in future epidmiologic studies and clinical trials, and associations with endothelial function, arterial stiffness, oxidative stress, and inflammation.
Principal Investigator: Ian de Boer, MD, MS
Trial Contact: Laura Curtin, 221-3938