EDUCATION AND TRAINING

Nephrology Fellowship (1986-88)
University of Texas Health Sciences Center, San Antonio, TX

Endocrinology and Metabolism Fellowship (1985-86)
Washington University
St. Louis, MO 

Internal Medicine Residency (1982-85)
Northwestern University Medical School
Chicago, IL

Medical School (1978-82)
Northwestern University Medical School
Chicago, IL

SITE OF PRACTICE:
Sacred Heart Medical Center
Spokane, WA

CONTACT INFORMATION
Providence Medical Research Center
104 W. 5^th Avenue; Suite 350E
Spokane, WA 99204
Phone: (509) 474-4345
Fax:  (509) 474-4325
Email: ktuttle@shmc.org

Administrative Contact: Charlotte Gray
Email: grayca1@shmc.org 

Administrative Contacts:
http://depts.washington.edu/nephron/
admin.htm

Katherine R. Tuttle, M.D., F.A.S.N., F.A.C.P.

Clinical Professor
Medical & Scientific Director, Providence Medical Research Center/Sacred Heart Medical Center
Professor of Basic Medical Sciences, WWAMI Program
Washington State University


 

CLINICAL INTERESTS

• Diabetic kidney disease
• Hypertension
• Renal vascular disease
• Chronic kidney diseases (CKD)

RESEARCH INTERESTS and CURRENT RESEARCH PROJECTS

• Diabetic kidney disease: cellular and molecular mechanisms, clinical research in novel therapeutic agents
• Nutrition: cellular and molecular mechanisms of dietary protein-induced kidney damage, clinical research on optimal dietary interventions
• Hypertension: clinical research in defining selection of therapeutic combinations
• Renal vascular disease: randomized clinical trial of medical versus interventional strategy
• Chronic kidney disease: randomized clinical trial of statins to evaluate effects on CKD and cardiovascular outcomes
• Glycemic management in diabetic patients with CKD: clinical trial

SELECTED PUBLICATIONS (from over 100 contributions):
Tuttle KR, Bruton JL, Perusek M, Lancaster JL, Kopp DT, DeFronzo RA. Effect of strict glycemic control on renal hemodynamic response to amino acids and renal enlargement in insulin-dependent diabetes mellitus. N Engl J Med 324:1626-1632,1991. 

Tuttle KR, Chouinard RF, Webber JT, Dahlstrom LR, Short RA, Henneberry KJ, Dunham LA, Raabe RD. Treatment of atherosclerotic ostial renal artery stenosis with the intravascular stent. Am J Kidney Dis 32:611-622,1998. 

Tuttle KR, Johnson EC, Cooney SK, Anderberg RJ, Johnson EK, Clifton GD, Meek RL. Amino acids injure mesangial cells by advanced glycation end products, oxidative stress, and protein kinase C. Kidney Int 67:953-968,2005. 

Tuttle KR, Bakris G, Toto R, McGill J, Hu K, Anderson PW. The effect of ruboxistaurin on nephropathy in type 2 diabetes. Diabetes Care 28:2686-2690,2005. 

Tuttle KR and Nelson RG (Eds.) for the KDOQI Work Group.  National Kidney Foundation – Kidney Disease Outcomes Quality Initiative (KDOQI), clinical practice guidelines and recommendations for diabetes and chronic kidney disease.  Am J Kidney Dis 49:S1-S179,2007.

AWARDS

• Fellow of the American Society of Nephrology, 2004
• Fellowship:  American College of Physicians-American Society of Internal Medicine, 2001
• Woman of Distinction:  Girl Scouts Inland Empire Council, 2000
• Outstanding Clinical Faculty, Internal Medicine-Spokane, 1992
• Alpha Omega Alpha, 1986

NATIONAL and INTERNATIONAL RESPONSIBILITIES

• Member, Executive Council on Hypertension, National Kidney Foundation 1998-current

• Member, Consensus Panel on Treatment of High Blood Pressure in Diabetes, National Kidney Foundation 1999

• Co-Chair, Diabetes and Chronic Kidney Disease Workgroup, National Kidney Foundation-Kidney Disease Outcomes Quality Initiative (KDOQI), 2003-current

• Chair, 2007-current, Member 2004-current, Health Care Provider Work Group, National Diabetes Education Program, National Institutes of Health, National Institute of Diabetes, Digestive, and Kidney Diseases

• Member, Operations and Steering Committees for the CORAL Trial, National Institutes of Health, National Heart, Lung, and Blood Institute, 2006-current

• Chair, Risk Factor Committee for the CORAL Trial, National Institutes of Health, National Heart, Lung, and Blood Institute, 2006-current

• Member, Planning Committee, Proteinuria as a Surrogate Outcome in Chronic Kidney Disease, National Kidney Foundation and United States Food and Drug Administration Consensus Panel, 2007-current