Dept.: Research Assistant Professor, School of Medicine, Gerontology Division
Neuroscience Focus Groups: Behavioral Neuroscience, Disorders of the Nervous System
We work to understand the molecular mechanisms driving neurodegeneration in Alzheimer’s disease, amyotrophic lateral sclerosis and other aging related neurodegenerative disorders. One feature common to age dependent neurodegeneration is abnormal aggregation of specific pathological proteins. We use a variety of model systems including C. elegans, cultured human cells, mice, and human tissue to explore neuroprotective strategies targeted against protein aggregation. Our focus is on identifying genetic pathways and small molecules preventing protein aggregation and the resulting neurotoxicity.