Graduate Program in Neuroscience

Stephen Smith

smith-stephenPhone: 206- 884- 7324
Deptartments: Assistant Professor, Department of Pediatrics Principle Investigator, Center for Integrative Brain Research, Seattle Children’s Research Institute Research Affiliate, Center for Human Development and Disease
Neuroscience Focus Groups: Cell and Molecular Neuroscience; Disorders of the Nervous System; Behavioral Neuroscience
Lab Link


The SEPS lab studies the molecular biology of the glutamate synapse, with a focus on the molecular mechanisms shared among different genetic causes of autism. The protein products of genes do not act in isolation, but form networks of multi-protein complexes, tiny molecular machines that function onl methods to analyze the behavior of these multi-protein complexes. We use these techniques, along with molecular and genetic approaches, to model dynamic protein interaction networks at the synapse, and to investigate how these networks are disrupted in autism.