Dept.: Assistant Professor, Department of Pharmacology
Neuroscience Focus Groups: Cell and Molecular Neuroscience, Developmental Neuroscience, Disorders of the nervous system, Excitable membranes and Synaptic transmission
The Yadav laboratory is interested in understanding how the human kinome controls neuronal development as well as how dysfunction in kinase pathways lead to neurodevelopmental and psychiatric disorders such as autism and schizophrenia. We utilize a combination of powerful approaches in chemical-genetics, induced pluripotent stem cell (iPSC) technology, high-resolution live cell imaging and quantitative proteomics to investigate the role of kinases and their downstream targets in neuronal development and disease. We are currently investigating the mechanisms by which abnormal gene dosage of TAOK2 kinase in 16p11.2 deletion and duplication contributes to neuronal alterations leading to autism spectrum disorders.