Dept.: Professor, Department of Environmental and Occupational Health Sciences (Toxicology program); Adjunct Professor, Department of Pharmacology
Neuroscience Focus Groups: Behavioral Neuroscience, Cell and Molecular Neuroscience, Disorders of the Nervous System
It has been hypothesized that exposure to environmental factors may increase Alzheimer’s disease (AD) risk. However, there is a paucity of evidence supporting this hypothesis. The hippocampus is critical for cognition and especially vulnerable to damage at early stages of AD. We are using transgenic mouse models to test the hypotheses that a gene-environment interaction between environmental exposure and the presence of gene(s) with increased risk for AD impairs adult hippocampal neurogenesis and contributes to neuronal loss and cognitive decline during aging and in neurodegeneration.