Graduate Program in Neuroscience

Jobs

09/18/2018

Scientist I– Neuroanatomy and Data Analysis (The Allen Institute; Seattle)

Our mission at the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Our research goals include generating and analyzing large-scale anatomical imaging data from Alzheimer’s disease mouse models. We are seeking a Scientist to join the Neuroanatomy team and to help with image processing and data analysis related to our whole-brain projection mapping projects.

As a member of this team, the Scientist will perform computational analyses aimed at understanding the organization of whole brain connectivity patterns and pathology in aging and diseased brains. She/he should have experience working with voxel-based image data, solid programming skills, and a strong background in mathematics and statistics. The Scientist will also be responsible for generating data visualizations, establishing signal detection metrics for primary data, generating computational models, performing statistical analysis on large datasets, and assisting with analysis and visualization of single cell RNA sequencing data.

For more information on this position, please visit: Scientist-Neuroanatomy and Data Analysis

 

Postdoc Fellow- University of Maryland (Maryland)

PhD students who are 12-18 months from graduating

Start date: September 1, 2019 or later; open until filled

Position Summary:  We are looking for one or more postdoctoral fellows to study the organization and activation of neural circuits supporting perceptual learning in Mongolian gerbils. Successful applicants will use a variety of techniques, such as wireless multichannel electrophysiology, targeted pharmacological brain infusions and optogenetics to measure and manipulate neural activity in awake, freely-moving animals engaged in behavioral auditory detection tasks. Candidates will be highly involved in all aspects of the research, from design to publication, and will additionally have the opportunity to mentor graduate and undergraduate students.

For more information visit: The Caras Lab 

08/06/2018

Assistant Professor Position in Psychology (Specializing in Neuroscience)– Whitman College, WA

There is a currently a tenure track assistant professor position specializing in Neuroscience available for the upcoming year. Applications are due by September 27, 2018 and a PhD is required. For more information, please see the original post here: Assistant Professor Position

 

Science Officer Positions– Ripple Effect (Maryland)

Ripple Effect Communications, Inc is a women-owned small business that does biomedical contracting for the federal government, and hires scientists who are interested in alternative careers. Ripple Effect currently has two openings for scientists with a neuroscience background.

Ripple Effect is looking to hire Science Officers to provide grants management support to CDMRP (Congressionally Directed Medical Research Programs). We are looking for applicants with backgrounds in biomedical research, particularly in neuroscience research. We are also looking for “generalists” who can work in any biomedical field. Positions are based on-site at CDMRP in Frederick, MD. A more detailed job posting is available here: Science Officer Position

All available positions are on the the Ripple Effect website: https://ripple-effect-communications-inc.workable.com/.

08/03/2018

 Post-Doc Position (research associate)- University College London (UCL) 

The project will record place cells in dorsal CA1 and cells in prelimbic/infralimbic cortex while rats perform navigation tasks in hierarchical environments. As part of the project, in parallel, a post-doc in Chris Summerfield’s Lab in Oxford will use a VR version of the rat task to test humans during fMRI. In addition, the data from rats and humans will be integrated with
modelling done by a post-doc in Giovanni Pezzulo’s lab in Rome.

Key Requirements 
Applicants must hold a PhD, or have submitted their thesis in Neuroscience/Psychology and have experience of neural recording in animals. The ability to work as part of a research team is essential, as is the ability to problem-solve in a technical setting. Computer skills include Matlab programming are desirable. Particular importance will be given to one or more of the following: experience with animal behavior, high level analytic skills, experience with multi-electrode recording or experience with computational modeling of navigation behavior.

Further Details

Applicants will be interviewed in September and the start date is in October. For more information please see: Research associate- Reference #1740251

 

07/25/2018

 

Technician  Position – University of Washington (Lattemann’s Lab)

There will be a technician position available in Dianne Lattemann’s lab at the VAPSHCS starting approximately October 1st.
Full time or part time and is negotiable ad will be discussed.
Skill Requirements: Basic rat handling and measurement skills. Brain surgery/cannulation skills desirable but training can be provided. Some tissue- and blood-sample processing skills or experience required.
Position will also require contributions to lbasic ab logistical activities (e.g., placing orders, regulatory compliances).

Reply to: Doamme Lattemann, latte@uw.edu

 

07/13/2018

Postdoctoral Position – University of Pittsburgh

A postdoctoral position is open for highly motivated candidates in the laboratory of Dr. Bokai Zhu at the Aging Institute of University of Pittsburgh School of Medicine. The Zhu lab recently discovered a cell-autonomous mammalian 12h-clock that runs independently from the circadian clock to regulate 12h oscillations of gene expression and metabolism (Zhu et al., Cell Metabolism, 2017, Zhu et al., JES, 2018). The Zhu lab is currently investigating the regulation as well as the physiological/pathological functions of the 12h-clock, with an emphasis on its roles in maintaining hepatic metabolic homeostasis and preventing aging-associated diseases. A combination of state-of-the-art computational, biochemical, genetic, cellular, imaging and genomic approaches is currently utilized in the lab. For a detailed description of the research performed in Zhu lab, please visit http://www.bzhulab.com.

The search is primarily targeted towards scientists who recently finished their PhD. Start date is after Sep 1st, 2018 and flexible. Researchers with a passion in systemic and quantitative chronobiology, transcriptional regulation of metabolism, and ER and mitochondria biology, regardless of their training background, are welcome to apply. Expertise in any of the following areas is highly valued though not required:

* In vivo mouse circadian and hepatic metabolism techniques

* Molecular biology, biochemistry and the field of regulation of gene expression

* Bioinformatics expertise in the analysis of NGS datasets such as RNA-Seq, ChIP-Seq and GRO-Seq

* Imaging-based cell biology techniques

Pitt med is a national leader in biomedical research. University of Pittsburgh School of Medicine is currently ranked 14th in the category of research by U.S. News and is separately ranked 17th in the Academic Ranking of World Universities list of best medical schools in the world. The medical school’s NIH funding level also ranks fifth in the nation.

To apply, please send a cover letter describing your past training, research interests and career goals, a detailed CV and contact information of three referees to Dr. Bokai Zhu at BZHU@pitt.edu.

 

06/29/2018

DHHS Research Fellow – Computational Biology Core

The National Institute on Aging (NIA), Intramural Research Program (IRP), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (DHHS), is recruiting a Research Fellow (RF) for the newly created Computational Biology Core, located in the Laboratory of Genetics and Genomics (LGG), NIA, NIH, Baltimore, MD.  The RF will work with the Computational Biology Core Head and NIA/IRP Principal Investigators to convert information to knowledge in projects utilizing ‘omics’ approaches, and in training NIA staff in computational approaches through classroom instruction.  The incumbent will analyze and integrate genomics and proteomics data as well as other ‘omics’ data.  Excellent interpersonal skills and a collaborative style are required.

Eligible candidates must have a Ph.D. or M.D. (or M.D., Ph.D.) or equivalent degree in the Biomedical Sciences/Bio-Statistics/Computer Science/Engineering, and have broad experience in computational biology, bioinformatics, genomics, aging, and age-related diseases documented by publications.  Experience in teaching, managing large datasets and computational tasks, and working in a Linux environment are essential.  Expertise in data analysis using a wide array of modern, open-source bioinformatics tools and scripting languages (e.g., Bash, Perl, Python and, R/Bioconductor) and strong statistical knowledge are required.

The successful candidate will have a strong background in multiple sequencing platforms as well as methods such as RNA-seq, ChIP-seq, CLIP-seq, nucleosome-seq, whole-genome sequencing, single-cell sequencing, and bisulfite sequencing.  The ability to perform cross-platform data integration is required, and knowledge of the above-mentioned methods is highly desirable, in order to assist Principal Investigators throughout the NIA with designing, troubleshooting, and identifying strengths and drawbacks of platforms and methods.

Salary is commensurate with research experience and accomplishments, and a full Civil Service package of benefits (including retirement, health, life and long-term care insurance, Thrift Savings Plan participation, etc.) is available. All employees of the Federal Government are subject to the conflict-of-interest statutes and regulations, including the Standards of Ethical Conduct.  Additional information about LGG is available at the following website:https://www.irp.nia.nih.gov/branches/lgg/lgg.htm.

To apply, please send a cover letter, curriculum vitae, bibliography, research interests, and three letters of recommendation to: Jamie Hertzfelt, Intramural Program Specialist; Office of the Scientific Director, Vacancy #NIA-IRP-18-03, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Blvd., Suite 100, Room 04C232, Baltimore, Maryland 21224 or email niairpjobs@mail.nih.gov.  The first review of applications will begin on or about August 20, 2018, but applications will be accepted until the position is filled.

06/15/2018

Postdoc opportunity, with a target start date of Fall 2018 (flexible).
Kenway Louie, MD PhD                  
Center for Neural Science
New York University
http://www.cns.nyu.edu/~klouie/
We’re currently hiring a postdoctoral research fellow interested in studying the computational and neurophysiological basis of decision making in monkeys. This postdoc will be part of an NIH-funded project looking at canonical neural computations in value coding and their relationship to optimal choice behavior, with a particular focus on the relationship between statistical regularities in the environment and adaptive neural responses. The work will be supervised by myself and Paul Glimcher, and be conducted at the Center for Neural Science at New York University.
If you know of anyone who would be a good candidate, please let them know about this opportunity. We’re primarily looking for anyone with a good foundation in systems neuroscience and an interest in neural coding and decision making, though electrophysiology experience (of any sort) would be a plus. Interested candidates can either email me directly <klouie@cns.nyu.edu> or visit the application site at https://apply.interfolio.com/50154

05/08/2018

Postdoctoral Research Position Available

William A. Catterall

Department of Pharmacology and Neuroscience Program

University of Washington, Seattle, WA 98195-7280 USA

Sodium Channels and Dravet Syndrome, an Intractable Childhood Epilepsy

Genetically dominant loss-of-function mutations in the type-1 brain sodium channel NaV1.1 cause Dravet Syndrome, which includes intractable epilepsy, ataxia, sleep and circadian disorders, severe cognitive deficit, autistic-like behaviors, and frequent premature death. We developed a mouse model of Dravet Syndrome that recapitulates all of its features. We found that NaV1.1 channels are particularly important for electrical excitability of GABAergic interneurons and that all of the manifestations of this disease are caused by failure of firing of GABAergic interneurons and disinhibition of neural circuits.

Our current research is aimed at understanding the defects in neural circuits that lead to the different manifestations of Dravet Syndrome and at developing novel, science-based therapies. We are using the Cre-Lox method to mutate NaV1.1 in specific cell types and in specific anatomical regions. We record the functional effects of these gene deletions on neurons and neural circuits in brain slices using patch clamp and in whole animals using tetrodes. We are using optogenetics and gene editing to rescue the impaired firing of specific disease-relevant classes GABAergic neurons. We are testing novel pharmacological approaches that are based on our emerging understanding of the detailed pathophysiology of this disease.  We hope that our research will lead to new understanding and practical therapies for this devastating disease.

See Rubinsteiin, Brain 2015; Kaplan, PNAS 2017; Catterall, Current Opinion in Physiology 2018

Position Requirements

Basic molecular and cellular biology, whole-cell voltage clamp physiology, and brain slice recording are required.

Experience with in vivo recording and behavioral studies in rodents is valuable.

We seek enthusiastic well-trained neuroscientists who are excited about the opportunity to analyze a devastating neuropsychiatric disease at cellular, circuit, and systems levels and develop novel therapeutic approaches.

Please respond to wcatt@uw.edu

05/08/2018

Postdoctoral Research Position Available

William A. Catterall

Department of Pharmacology and Neuroscience Program

University of Washington, Seattle, WA 98195-7280 USA

Calcium Channel Regulation, Presynaptic Plasticity, and Spatial Learning and Memory

Presynaptic CaV2.1 channels initiate neurotransmission at synapses in the brain. They are regulated by binding of calmodulin to a bipartite regulatory site in the proximal C-terminal domain. During trains of stimuli, initial calcium binding to high-affinity EF hands 3 and 4 causes facilitation of the calcium current and subsequent calcium binding to low-affinity EF hands 1 and 2 causes inactivation. In cultured sympathetic neurons, transfected CaV2.1 channels induce short-term presynaptic plasticity that is blocked by the IM-AA mutation in their calmodulin regulatory site. We have developed an IM-AA mutant mouse line, in which presynaptic plasticity is impaired at hippocampal synapses. The deficit in presynaptic plasticity leads to altered excitation/inhibition ratio in hippocampal circuits, weakened long-term potentiation of synaptic transmission, and dramatically impaired spatial learning and memory.

Our current experiments are aimed at understanding how the IM-AA mutation impairs spatial learning and memory at the cellular, circuit, and systems levels. We will use molecular and cellular biology, whole-cell voltage clamp, and synaptic physiology to probe the underlying mechanisms for the effects of the IM-AA mutation on short-term synaptic plasticity and long-term potentiation at synapses in the hippocampus. We will study the input-output relationships of neural circuits in the hippocampal slice. We will use tetrodes and optical probes to record circuit functions of the hippocampus in vivo in awake, behaving mice, including studies of hippocampal sharp waves and sharp-wave ripples. Based on these results, we will develop realistic neural models for the changes in cellular and circuit function that impair spatial learning and memory in IM-AA mice.

See Nanou et al, PNAS 2016; J Neurosci 2018; Neuron 2018

Position Requirements

Basic molecular and cellular biology, whole-cell voltage clamp physiology, and brain slice recording are required.

Experience with in vivo electrophysiology and behavior in rodents is valuable.

We seek enthusiastic well-trained neuroscientists who are excited about the opportunity to study the mechanisms of synaptic plasticity, learning, and memory from calcium channel structure and function to neural circuits and behavior.

Please respond to wcatt@uw.edu

05/04/2018

Scientist and/or Sr. Research Associate Position – Kineta, Inc.

The open scientific position(s) will support the preclinical development of conopeptide-based therapeutics for treating neuropathic pain. The successful candidate will be responsible for the design, execution and interpretation of in vitro and in vivo experiments related to the characterization of lead compounds using electrophysiology and pharmacodynamic animal models. Hands on experience with technical methods utilized in nociception studies is required including familiarity with drug- and/or nerve injury-induced neuropathic pain, and behavioral testing including von Frey, Randal-Selitto, Hargreaves and cold plate tests. In addition, the successful candidate will participate in evaluating drug mechanism of action using in vitro and ex vivo assays.

Essential experience and skills —

Experience including whole blood and cell subtype isolation, cell culture and cell-line generation, immunohistochemistry, Luminex, FACS and ELISA, in vitro and in vivo electrophysiology are a plus. Good communication skills and ability to collaborate across multidisciplinary scientific discovery settings. The candidate will be required to work both independently and in a multidisciplinary team setting to ensure timely completion of studies and is expected to present experimental findings at internal meetings and through written reports. Good communication skills and ability to collaborate across multidisciplinary scientific discovery settings. A successful candidate will possess proven skills to adapt and quickly learn new techniques in a dynamic drug discovery environment. This person will be a highly motivated individual with excellent organizational skills. Independent thinking and excellent communications skills are desired.

Desired qualifications – 

  • Bachelors within >6 years of neuroscience working experience.
  • Master’s degree with >3 years of relevant neuroscience experience.
  • A Ph.D. with experience in the field of neuroscience required.
  • Strong experience in neuroscience and behavioral models
  • Ability to work in the vivarium.
  • Computer proficient (Windows), possess excellent written and oral communication skills.
  • Show attention to detail.
  • Experience working in a fast-paced research environment

Contact Kineta, Inc for more details – www.kinetabio.com

04/20/2018

Postdoctoral Position – Computational Modeling of Brain Networks

Stanford University’s Department of Psychiatry & Behavioral Sciences is seeking to hire a full time post-doctoral fellow for their Cognitive & Systems Neuroscience Laboratory. This lab is headed by Dr. Vinod Menon who has broad multidisciplinary expertise that spans several scientific disciplines and has published extensively on various aspects of human cognition and brain function.
 
Explore our lab website for more information: http://med.stanford.edu/scsnl.html.
Currently Available: The Stanford Cognitive and Systems Neuroscience Laboratory invites applications for a postdoctoralfellowship in computational modeling of human brain imaging data using deep neural networks. The successful candidate will be involved in a multidisciplinary project that seeks to develop novel computational frameworks for robust identification of neurobiological signatures of psychiatric and neurological disorders combining deep learning and convolution networks and dynamic brain circuit analyses with task and resting-state fMRI. Clinical disorders currently under investigation include autism, ADHD, anxiety and mood disorders, learning disabilities, schizophrenia, and Parkinson’s disease. We seek talented and highly-motivated individuals with a strong background in at least one of these areas: deep learning algorithms and optimization (theory and practical implementations); computational modeling, statistical inference, and machine learning, especially as applied to fMRI and MRI data. The candidate will have access to multiple large datasets and state-of-the-art computational resources, including HPCs and GPGPUs. Please email a CV, statement of research interests and relevant background, and have three letters of reference sent to Drs. Vinod Menon and Aarthi Padmanabhan at scsnl.stanford+postdoc@gmail.com

03/23/2018

Postdoctoral Position – Molecular Neurobiology – SCRI

The SEPS lab (http://faculty.washington.edu/seps ) at the Center for Integrative Brain Research, Seattle Children’s Research Institute and the University of Washington invites applications for a postdoctoral position. Work in the SEPS lab focuses on shared molecular pathology among the many genetic causes of autism.

The successful candidate will work closely with a technician and graduate/undergraduate students to plan and supervise several parallel lines of investigation involving primary neuronal cell culture, genetic mouse models, and human iPS cells. The candidate will be expected to independently move projects forward, write papers, and apply for F32 or equivalent grants. The ideal candidate will have the ability to perform precise wetlab work and complex bioinformatics analyses. Prior experience with human iPS cell culture and MatLab or R programming would be beneficial. Creative, big-picture thinking and dedication to autism research are essential.

The selected candidate will join the vibrant research community at CIBR, located on the top floor of a newly renovated building in downtown Seattle. A modern, open lab space, a collegial atmosphere, on-site gym and rooftop garden, and top-of-the-line equipment, office space and meeting rooms make this an ideal training environment. Initial appointment will be for one year, with extension contingent on funding and performance.