Garden Laboratory

Publications

  • Kaul M, Garden G and Lipton S. (2001) Pathways to Neuronal Injury and Apoptosis in HIV-Associated Dementia. Nature 410:988-994.
  • Garden G, Budd S, Tsai E, Hanson L, Kaul M, De'Emillia D., Friedlander R, Yuan J, Masliah E and Lipton S. (2002) Caspase Cascades in Human Immunodeficiency Virus-Associated Neurodegeneration.  J. Neurosci. 22:4015-4024.
  • Garden G, Libby R, Fu Y-H, Kinoshita Y, Huang J, Possin D, Smith A, Martinez R, Fine G, Grote S, Ware C, Einum D, Morrison R, Ptacek L, Sopher B and La Spada A (2002) Polyglutamine Expanded Ataxin-7 Promotes Non-Cell Autonomous Purkinje Cell Degeneration And Displays Proteolytic Cleavage In Ataxic Transgenic Mice.  J. Neurosci. 22:4897-4905 (Selected as Cover Article)
  • Garden G. (2002) Microglia in Human Immunodeficiency Virus-Induced Neurodegeneration.  Glia  40:240-251.
  • Morrison R, Kinoshita Y, Johnson M, Guo W and Garden G (2003) p53-dependent Cell Death Signaling in Neurons.  Neurochem Res.  28:15-27
  • Hu S, Walker M, Czartoski T, Cheng A, Forghani B, Gilden D and Garden G (2004) Acyclovir-Responsive Brain Stem Disease Following the Ramsay Hunt syndrome.  J. Neurol. Sci., 217:111-113.
  • Digicaylioglu, M, Garden G, Timberlake S, Fletcher L and Lipton S (2004) Acute Neuroprotective Synergy of Erythropoietin and Insulin-Like Growth Factor-1. Proc. Natl. Acad. Sci. 101(26):9855-60.
  • Garden G, Guo W, Jayedev S, Tun C, Balcaitis S, Choi J, Montine T, Möller T and Morrison R (2004) HIV Associated Neurodegeneration Requires p53 in Neurons and Microglia. FASEB J. 18(7):U567-569. Full length version published on line at www.fasebj.org/cgi/content/abstract/04-1676fjev1.
  • Garden G and Morrison R. (2005) The Multiple Roles of p53 in the Pathogenesis of HIV Associated Dementia. Biochem. Biophys. Res. Comm. 331(3):799-809.
  • Takaya N, Yuan C, Chu G, Saam T, Underhill H, Cai J, Tran N, Polissar N, Isaac C, Ferguson M, Garden G, Cramer S, Maravilla K, Hashimoto B and Hatsukami T, (2006) Association Between Carotid Plaque Characteristics and Subsequent Ischemic Cerebrovascular Events: A Prospective Assessment with Magnetic Resonance Imaging.  Stroke 37:818-23.
  • Garden G and Möller T. (2006) Microglia Biology in Health and Disease. J. Neuroimmun. Pharmacol. 1:127-137.
  • Custer S, Garden G, Gill N, Libby R, Guyenet S, Westrum L, Sopher B, Laspada A. (2006) Bergmann glia expression of polyglutamine-expanded ataxin-7 produces Purkinje cell degeneration and implicates glial-induced impairment of glutamate transport in SCA7. Nature Neurosci. Oct 9(10):1302-11
  • Saam T, Yuan C, Chu B, Takaya N, Underhill H, Cai J, Tran N, Polissar N, Neradilek B, Jarvik G, Isaac C, Garden G, Cramer S, Maravilla K, Hashimoto B and Hatsukami T. (2006) Predictors of Carotid Athersclerotic Plaque Progression as Measured by Noninvasive Magnetic Resonance Imaging. Atherosclerosis Sep 13: doi:10.1016
  • Kinoshita Y, Uo T, Jayadev S, Garden G, Conrads T, Veenstra T and Morrison R. (2006) Potential Applications and Limitations of Proteomics in the Study of Neurological Disease. Archives of Neurol. 63:1692-1696.
  • Tun C, Guo W, Nguyen H, Yun B, Libby R, Morrison R and Garden G. (2007). Activation of the extrinsic caspase pathway in cultured cortical neurons requires p53 mediated down regulation of the X-linked inhibitor of apoptosis protein to induce apoptosis. J. Neurochem. 102:1206-1219.
  • Jayadev S, Yun B, Nguyen H, Yokoo H, Morrison R and Garden G.  (2007) The Glial Response to CNS HIV Infection Includes p53 Activation and Increased Expression of p53 Target Genes. J. Neuro. Immun. Pharmacol. 2(4):359-70.
  • Garden G and La Spada A (2008) Molecular Pathogenesis and Cellular Pathology of Spinocerebellar Ataxia Type 7 Neurodegeneration. The Cerebellum. 7(2):138-49. PMID: 17853090.
  • Young J*, Garden G*, Martinez R, Tanaka F, Sandoval C, Smith N, Sopher B, Lin A, Fischbeck K, Ellerby L, Morrison R, Taylor J, and La Spada A, (2009) Polyglutamine-expanded androgen receptor truncation fragments activate a Bax-dependent apoptotic cascade mediated by DP5/Hrk. J Neurosci. 29(7):1987-97. PMID: 19228953.  (*=Equal Contributions)
  • Jayadev S and Garden G (2009) Host and Viral Factors Influencing the Pathogenesis of HIV Associated Neurocognitive Disorders. J. Neuroimmun. Pharmacol. 4(2):175-189, PMID:19345186.
  • Klintworth H, Garden G and Xia Z (2009) Rotenone And Paraquat Do Not Directly Activate Microglia or Induce Inflammatory Cytokine Release. Neurosci Lett. 462(1):1-5. PMID: 19559752
  • Chakrabarti L, Eng J, Gill N, Garden G and La Spada A (2009) Autophagy Activation and Enhanched Mitophagy Characterize the Purkinje Cells of pcd Mice Prior to Neuronal Death. Mol. Brain. 2(1):24. PMID: 19640278.
  • Guyenet S, Furrer S, Damian V, Baughan T, La Spada A, Garden G (2010). A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia. J. Vis. Exp. http://www.jove.com/index/details.stp?id=1787, doi: 10.3791/1787. PMID: 20495529.
  • Jayadev S, Case A, Nguyen H, Möller T, Morrison R and Garden G (2010) Presenilin 2 is the Predominant γ-secretase in Microglia and Modulates Cytokine Release. PLOS One. 5(12):e15743. PMID: 21206757.
  • Jayadev S, Nessor N, Hopkins S, Myers S, Case A, Lee R, Seaburg L, Uo T, Murphy S, Morrison R and Garden G (2011) The Transcription Factor p53 Influences Microglia Activation Phenotype. Glia. 59(10):1402-13. PMID: 21598312.
  • Furrer S, Mohanachandran M, Waldherr S, Chang C, Damian V, Sopher B, Garden G* and La Spada A* (2011) SCA7 Cerebellar Disease Requires The Coordinated Action Of Mutant Ataxin-7 In Neurons And Glia, And Displays Non-Cell Autonomous Bergmann Glia Degeneration. J Neurosci. 31(45):16269-78. PMID: 22072678. (*=Equal Contributions)
  • Jebelli J, Hooper C, Garden G and Pocock J (2012) p53 in the CNS: emerging roles for Glia. Glia; 60 (4) 515-25. PMID: 22105777.
  • Garden G and La Spada A. (2012) Intercellular (Mis)communication in Neurodegenerative Diseases. Neuron. 73(5):886-901.