The Weinstein Laboratory
Dr. Jonathan Weinstein is the principal investigator of the Weinstein Laboratory in the Department of Neurology, University of Washington School of Medicine. The main focus of research in the Weinstein lab is to elucidate the role of microglial cell activation in the neuroinflammatory response associated with ischemic preconditioning and stroke. Ischemic preconditioning (IPC) in the brain is a robust neuroprotective phenomenon in which a brief ischemic exposure increases resistance to the injurious effects of subsequent prolonged ischemia. Microglia (Fig. 1), the brain's resident tissue macrophages, are the primary mediators of neuroinflammation and are critical in the pathophysiology of stroke. Mechanistic information on the function of microglia in ischemia is limited and the role of microglia in IPC is unknown. All projects in our laboratory focus on characterizing the role of microglia in both IPC and stroke.
Stroke is the leading cause of serious long-term disability in the United States and few stroke patients qualify for the only FDA approved therapy, IV tPA. Thus, our ultimate goal is to improve the understanding of the mechanisms of neuroinflammation in stroke and identify possible molecular targets for therapeutic intervention.