Daniel L. Silbergeld, M.D.
Arthur A. Ward, Jr. Professor
Chief of Neurosurgery at U.W.M.C.

Dr. Silbergeld is the Chief of Neurosurgery and an attending neurosurgeon at the University of Washington School of Medicine, holding both an Professor of Neurosurgery and an Adjunct Professor of Pathology.

He received his medical degree from the University of Cincinnati College of Medicine in 1984. Dr. Silbergeld then completed a neurosurgery residency at the University of Washington, followed by a two-year research fellowship in the Northwest Neuro-Oncology Research and Therapy Section as well as two additional fellowships -- one in neuro-oncology and the other in epilepsy surgery.  After spending five years at Washington University in St. Louis as assistant professor in the Department of Neurosurgery and Neurobiology, he returned to Seattle in 1997 after being appointed to the faculty in the Department of Neurological Surgery at the University of Washington. 

Patient Care
Dr. Silbergeld's clinical practice focuses on brain tumors as well as epilepsy surgery with special expertise in functional brain mapping for language, movement and sensation.

Research
Dr. Silbergeld’s research laboratory is currently investigating glioma invasion and motility. His laboratory is working with Dr. Pierre Mourad to investigate the use of high-intensity focused ultrasound to temporarily disrupt the blood-brain barrier to enable delivery of chemotherpeutic agents to brain tumors.

"When participating in teaching, research and patient care, caring for the patient and providing continuity of care is my primary mission. Participating in multi-disciplinary teams allow a unique patient-based system that offers excellent state-of-the-art care that cannot be provided by individual physicians." - Dr. Dan Silbergeld

Education and Training
1979 BS in Psychology, Duke University, Durham, NC

1984 MD, University of Cincinnati College of Medicine, Cincinnati, OH

1984-85 Internship in General Surgery, Department of Surgery, University of Washington, Seattle, WA

1985-90 Resident, Department of Neurological Surgery, University of Washington, Seattle, WA

1987-88 Research Fellow, Northwest Neuro-Oncology Research and Therapy Section, Department of Neurological Surgery, University of Washington, Seattle, WA

1988-89 Registrar in Neurological Surgery, Atkinson Morley’s Hospital, St. George Medical School, Wimbledon, England

1989 Fellow, Neuro-Oncology, University of Washington, Seattle, WA

1990-92 Acting Instructor, Neurological Surgery, University of Washington, Seattle, WA

1991 Fellow, Epilepsy Surgery, University of Washington, Seattle, WA

1992-97 Assistant Professor Department of Neurosurgery and Neurobiology, Washington University, St. Louis, MO

1997- Associate Professor, Department of Neurological Surgery, University of Washington, Seattle, WA

Research Grants (since 2000)
April 2000 - March 2003
National Cancer Institute Grant (co-investigator; R01 CA 82622)
National Institutes of Health
“Combating Alkylating Agent Resistance in Human Gliomas”

July 1999 - July 2001
Sponsor: National Research Service Award (CA83254)
Recipient: Dr. Paul Santiago
National Cancer Institute,
National Institutes of Health
“Quantification of Malignant Brain Tumor Invasion”

July 1999 - July 2001
Sponsor: National Research Service Award (NS10897)
Recipient: Dr. Ali Mesiwala
National Institute of Neurologic Disorders and Stroke,
National Institutes of Health
“Blood-Brain Barrier Disruption Using Ultrasound”

July 1999 - July 2001
Sponsor: American Brain Tumor Association Fellowship Award
Recipient: Dr. Ali Mesiwala
American Brain Tumor Association
“Blood-Brain Barrier Disruption Using High Intensity Focused Ultrasound”

May 1999 - May 2004
Program Project Grant (co-investigator; U01 CA81454)
National Cancer Institute,
National Institutes of Health
“Pediatric Brain Tumor Clinical Trials Consortium”

March 1998 - March 2003
Program Project Grant (co-investigator; PO1 CA42045)
National Cancer Institute,
National Institutes of Health
“Metabolic Imaging of cancer and its response to therapy”

March 1996 - March 2002
First Award (R29CA NS69640)
National Cancer Institute,
National Institutes of Health
"Astrocytoma Motility and Invasion"

May 1994 - May 2000
Career Investigator Development Award (KO8 NS01730)
National Institute of Neurologic Disorders and Stroke,
National Institutes of Health
"Invasive Nature of Malignant Astrocytomas"

Institutional Principal Investigator: Rhone-Poulenc Rorer (UWNG 98-01). Phase II Study of Concomitant Gliadel Wafer and Iodine-125 Seed Implantation Following Surgical Resection for Glioblastoma Multiforme or Gliosarcoma. University of Washington, Seattle. 1999-

Institutional Co-Principal Investigator: Cyberonics Corp. “Determination of the Effectiveness of Vagal Nerve Stimulation Therapy in the Treatment of Refractory Generalized Seizures” University of Washington, Seattle. February 1999-

Institutional Co-Principal Investigator: British Biotech, #C03/IVB/131. A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Trial of Marimastat in Patients with Glioblastoma Mutiforme or Gliosarcoma Following Completion of Conventional First-Line Treatment. University of Washington, Seattle. 1997-2000

Institutional Co-Principal Investigator: Rhone-Poulenc Rorer #250MA. Phase II Trial of Surgery with Wafer and Radiation in Patients with Operable CNS Metastases from Systemic Cancer. University of Washington, Seattle. 1997-2000

Institutional Co-Principal Investigator: A Phase III Study of Neoadjuvant Intravenous Cereport and Carboplatin in the Treatment of Newly Diagnosed Glioblastoma Multiforme: ALK01-040. University of Washington, Seattle, 1997-2000

Institutional Co-Principal Investigator: A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Trial of Marimastat in Patients with Glioblastoma Multiforme or Gliosarcoma Following Completion of Conventional First-Line Treatment. University of Washington, Seattle, 1997-2000

Institutional Co-Principal Investigator: Phase II Study of Coventional Radiotherapy Plus Radiotherapy Boost to Regions with Increased FDG/PET Uptake for Glioblastoma Multiforme or Gliosarcoma (UWNG 97-01). University of Washington, Seattle, 1997-

Selected Publications
1. Silbergeld DL, Rostomily RC, Alvord EC: The Causes of Death in Patients with Glioblastoma is Multifactorial: Clinical Factors and Autopsy Findings in 117 Cases of Supratentorial Glioblastoma in Adults. J Neuro-Oncol 1991;10:179-185 PubMed abstract

2. Silbergeld DL, Ali-Osman F: Isolation and Characterization of Microvessels from Normal Brain and Brain Tumors. J Neuro-Oncol 1991;11:49-55 PubMed abstract

3. Silbergeld DL, Ali-Osman F, Winn HR: Induction of Transformational Changes in Normal Endothelial Cells by Glioblastoma Cells in Culture. J Neurosurg 1991;75:604-612 PubMed abstract

4. Pilcher WH, Silbergeld DL, Berger MS, Ojemann GA: Intraoperative Electrocorticography During Tumor Resection: Impact on Seizure Outcome in Patients with Gangliogliomas. J Neurosurg 1993;78:891-902 PubMed abstract

5. Chicoine MR, Silbergeld DL: Assessment of Brain Tumor Cell Motility in vitro and in vivo. J Neurosurg 1995;82:615-622

6. Chicoine MR, Silbergeld DL: Modification of Human Glioma in vitro Locomotion by Cytokines EGF, FGF, PDGFbb, NGF, and _TNF. Neurosurgery 1995;36:165-171

7. Chicoine MR, Silbergeld DL: Invading C6 Glioma Cells Maintain Tumorgenicity. J Neurosurgery 1995;83:665-671

8. Silbergeld DL, Chicoine MR, Madsen CL: In vitro assessment of taxol for human glioblastoma: chemosensitivity and cellular locomotion. Anti Cancer Drugs 1995, 6:270-276 1995 PubMed abstract

9. Chicoine MR, Silbergeld DL: In Vitro Motility of Human Gliomas Increases with Increasing Grade of Malignancy. Cancer 1995;75:2904-2909 PubMed abstrat

10. Ojemann JG, Miller JW, Silbergeld: Preserved function in brain invaded by tumor. Neurosurgery 1996 39:253-259 PubMed abstract

11. Chicoine MR, Silbergeld DL: Mitogens as motogens. J Neuro-Oncol. 1997 35:249-257

12. Silbergeld DL, Chicoine MR: Isolation and characterization of human malignant glioma cells from histologically normal brain. J Neurosurg. 1997; 86(3):525-31 PubMed abstract