In vitro validation of computational fluid dynamics modeling of intracranial aneurysms treated with flow-diverting stents

The focus of the current proposal is patient-specific in vitro aneurysm modeling, in which benchtop models of actual patients’ aneurysms are created using high-fidelity three-dimensional printing. These aneurysms are then “treated” with the same medical devices (e.g. stents and coils) as was used in actual patient care. Direct observation of hemodynamic variables such as intraaneurysmal flow can then be observed using modalities unavailable in vivo. Direct measurement of hemodynamic changes after treatment with actual devices could better inform purely computational fluid dynamics (CFD) models, reducing error and improving CFD accuracy. Such improvement increases the likelihood that corrected CFD models alone could provide accurate calculations of the immediate hemodynamic effect of treatment as hypothesized in the overarching outcome study, which could potentially change the clinical strategy should unfavorable CFD conditions persist after endovascular treatment.

Principal Investigator(s)