James Bales, M.D., Ph.D.

James Bales' portrait
Job Title
Resident
Biography

As an MD/PhD student at the University of Pittsburgh, James was the institutional representative to the American Physician Scientist Association, and a graduate teaching assistant in the undergraduate neurophysiology course. He was also elected student chair of the MD/PhD program. 

Research Interests

Traumatic Brain Injury

Personal Interests

Biking, fencing, computer and writing.

Education

Undergraduate Education

Washington State University

Doctorate of Philosophy

University of Pittsburgh

Medical Education

University of Pittsburgh

Contact Information

 

    Publications

    Articles; Chapters;

     

    1. Bales., J.W. Trans-anal presentation of a distal ventriculoperitoneal shunt catheter: Management of bowel perforation without laparotomy. Submitted Pediatric Neurosurgery.

    2. Bonow, R., Bales, J.W., Morton, R., Levitt, M., Zhang, F. Intracranial Hypotension in the setting of a history of laminectomy. Journal of Neurosurgery: Spine, 2015.

    3. Yan, H.Q., Osier, N.D., Korpon, J., Bales, J.W., Kline, A.E., Wagner, A.K., Dixon, C.E. Persistent Cognitive Deficits: Implications of Altered Dopamine in Traumatic Brain Injury. Chapter in Brain Neurotrauma. 2015

    4. Shin, S.S., Bales, J.W., Yan, H.Q., Kline, A.E., Wagner, A.K., Lyons-Weiler, J., Dixon, C.E. The effect of environmental enrichment in substantia nigra gene expression following a traumatic brain injury in rats. J. Neurotrauma 2013.

    5. Bales, J.W., Yan, H.Q., Ma, X., Li, Y., Samarasinghe, R., Dixon, C.E. Dopamine and cAMP regulated phosphoprotein, 32 kDA: A novel therapeutic target in traumatic brain injury. Exp Neurol. 2011 Jun;229(2):300-7.

    6. Bales, J.W., Ma, X., Yan, H.Q., Jenkins, L.W., Dixon, C.E. Alterations in calcineurin subunit B isoform expression in rat hippocampus following a traumatic brain injury. Brain Res. 2010 Oct 28;1358:211-20.

    7. Bales, J.W., Macfarlane, Kristin, Dixon, C.E. Neurobehavioral Assessments of Traumatic Brain Injury. In: Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments. Chen, J.; Xu, X.-M.; Xu, Z.C.; Zhang, J.H. (Eds.) 2011. Springer.

    8. Bales, J.W., Macfarlane, Kristin, Dixon, C.E. Vestibular – Beam Walking, Beam Balance, Grip Strength. In: Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments. Chen, J.; Xu, X.-M.; Xu, Z.C.; Zhang, J.H. (Eds.) 2011. Springer.

    9. Bales, J.W., Kline, A.E., Wagner, A.K., Dixon, C.E. Targeting Dopamine in Acute Traumatic Brain Injury. The Open Drug Discovery Journal, 2010.

    10. Bales, J.W., Ma, X., Yan, H.Q., Jenkins, L.W., Dixon, C.E. Expression of protein phosphatase 2b (calcineurin) subunit a isoforms in rat hippocampus following a traumatic brain injury. Journal of Neurotrauma. 2010 Jan;27(1):109-20.

    11. Bales, J.W., Wagner, A.K., Kline, A.E., Dixon, C.E. Persistent Cognitive Dysfunction After Traumatic Brain Injury: A Dopamine Hypothesis. Neuroscience and Biobehavioral Rev. 2009 Jul;33(7):981-1003

    12. Schmitter-Edgecombe, M; Bales, J. Understanding text after severe closed-head injury: Assessing inferences and memory operations with a think-aloud procedure. Brain Lang. 2005 Sep;94(3):331-46.

     

    Abstracts:

     

    1. Bales, J., Cho, S., Korab, G., Khandelwal, N., Thao, T., Joffe, A. Sodium Variance and Hyponatremia as Predictors of Functional Outcome in Subarachnoid Hemorrhage patients. (Abstract for AANS 2015)

    2.  

    3. Cho, S., Bales, J., Korab, G., Khandelwal, N., Thao, T., Joffe, A. Nimodipine 14 versus 21 Days in Aneurysmal Subarachnoid Hemmorhage. (Abstract for ACCP 2015)

    4. Bales, J., Ochalski, P., Caltagarone, J., Chang, Y., Fellows-Mayle, W., Okonkwo, D., Stafford, P., Dixon, C.E., Treiman, L., Adelson. P.D. Microarray based gene expression analysis following Controlled Cortical Impact injury and post injury flumazenil treatment in Immature (Post Natal Day 17) Rats. (Abstract for poster presentation: Neurotrauma 2012)

    5. Bales, J., Macfarlane, K., Dixon, C.E. FK-506 and Amantadine: A Combined treatment strategy targeting DARPP-32 following an Experimental Traumatic Brain Injury. (Abstract for poster presentation: Neurotrauma 2012)

    6. Bales, J., Garringer, J., Conley, Y., Puccio, A., Okonkwo, D., Dixon, C.E. Association between the PPP3CC gene, coding for the calcineurin gamma catalytic subunit, and severity of traumatic brain injury in humans. (Abstract for poster presentation: Neurotrauma 2011)

    7. Bales, J., Yan, H., Ma, X., Li, Y., Macfarlane, K., Samarasinghe, R., Dixon, C.E. Striatal DARPP-32/PP-1 signaling dysfunction: A novel therapeutic target in traumatic brain injury. (Abstract for poster presentation: Society for Neuroscience 2010)

    8. Bales, J., Yan, H., Ma, X., Li, Y., Macfarlane, K., Samarasinghe, R., Dixon, C.E. Chronic striatal p-DARPP-32-thr34/PP-1 signaling alterations following a traumatic brain injury. (Abstract for poster presentation: Neurotrauma 2010)

    9. Bales, J., Ma, X., Yan, H., Jenkins, L., Dixon, C.E. Regional alterations in protein phosphatase 2B (calcineurin) subunit isoform distribution in rat hippocampus following traumatic brain injury. (Abstract for poster presentation: Society for Neuroscience 2009; Neurotrauma 2009)

    10. Bales, J., Yan, H., Kochanek, P., Dixon, C.E. In Vivo Adenosine A2a-Receptor and Dopamine D2-Receptor Heterodimer Expression Following Controlled Cortical Impact in Rat Striatum. (Abstract for poster presentation: Society for Neuroscience 2008; Neurotrauma 2008)

    11. Bales, J., Yan, H., Li, Y., Ma, X., Kochanek, P.M., Dixon, C.E. Effects of traumatic brain injury on adenosine A2A-receptor expression in rat striatum. (Abstract for poster presentation: Society for Neuroscience, 2007)

    12. Yan, H., Ma, X., Li, Y., Bales, J., Dixon, C.E. Down-regulation of dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDA phosphorylation at threonine 34 (pDARPP32-T34) in rat striatum after traumatic brain injury. (Abstract for poster presentation: Society for Neuroscience, 2007)

    13. Sices, L; Bales, J; Mercer, MB; Serna, S. Communication About Developmental Concerns and Delays in Early Childhood: Parent and Early Intervention Specialist Perspectives. (Abstract for poster presentation: Pediatric Academic Societies meeting in San Francisco on 4/29/06)

    14. Bales, J; Schmitter-Edgecombe, M. Understanding Text: On-line Inferences and Memory Operations after Severe Closed Head Injury. (Abstract for poster presentation: Cognitive Neuroscience Society Symposium, 2004)

    15. Hinson, J; Whitney, P; Bales, J. The Role of Somatic Markers in Behavioral Inhibition. (Abstract for poster presentation: Cognitive Neuroscience Society Symposium, 2004)