Anoop P. Patel, M.D.

Portrait of Anoop Patel, M.D.
Job Title
Assistant Professor of Neurological Surgery
Biography

Dr. Patel is a UW assistant professor of Neurosurgery who specializes in the treatment of brain tumors. Specifically, he is an expert in the treatment of malignant brain tumors, skull base tumors, vascular lesions, and cranial neuropathies through open and endoscopic approaches.

Dr. Patel earned his bachelor’s degree from Yale University and his medical degree from Harvard Medical School. He went on to do internship and residency in Neurosurgery at the Massachusetts General Hospital in Boston. He came to the UW for advanced training in skull base and cerebrovascular surgery.

Dr. Patel is a member of the American Association of Neurological Surgeons, the Congress of Neurological Surgeons, and the North American Skull Base Society. He is also a recipient of the Burroughs Wellcome Foundation Career Award in Medical Sciences for his research efforts on glioblastoma.

Clinical Interest

Treatment of tumors of the skull base, brain and spinal cord, including malignant brain tumors (low grade glioma, glioblastoma, metastatic disease); meningiomas; schwannomas (acoustic neuromas/vestibular schwannomas, trigeminal, glossopharyngeal, hypoglossal, spinal); pituitary tumors; craniopharyngiomas; neurofibromatosis type 1 and 2 (acoustic neuromas, schwannomas, meningiomas); chordomas and chondrosarcomas; hemangioblastomas; cranial nerve syndromes (trigeminal neuralgia, hemifacial spasm); hemangioblastomas; sinonasal tumors of the skull base; and cysts (epidermoid, dermoid, Rathke's cleft).

Research Interests

Using detailed profiling of patient tumors to understand how tumor heterogeneity leads to treatment resistance in glioblastoma.

Personal Interests

Scuba diving, golfing, hiking, camping.

Education

Medical Education

Harvard Medical School

Internship

Massachusetts General Hospital

Residency

Massachusetts General Hospital

Fellowship

University of Washington

Contact Information

 

    Publications

    BOOK CHAPTERS:

    • Patel AP, Amin-Hanjani S, Ogilvy CS. Surgical management of cavernous malformations. In: Quinones-Hinojosa A (ed). Schmidek, Schmidek and Sweet’s Operative Neurosurgical Techniques, 6th edition. 2012. Saunders. Chapter 81. pp 977-994

    PEER-REVIEWED ARTICLES:

    • Liau BB, Sievers C, Donohue LK, Gillespie SM, Flavahan WA, Miller TE, Venteicher AS, Hebert CH, Carey CD, Rodig SJ, Shareef SJ, Najm FJ, van Galen P, Wakimoto H, Cahill DP, Rich JN, Aster JC, Suva ML, Patel AP*, Bernstein BE*. Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Cell Stem Cell. 2017;20(2):233-46 e7. Epub 2016/12/19. doi: 10.1016/j.stem.2016.11.003. PMC5291795. *Co-senior author
    • Venteicher AS, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin MG, Hovestadt V, Escalante LE, Shaw ML, Rodman C, Gillespie SM, Dionne D, Luo CC, Ravichandran H, Mylvaganam R, Mount C, Onozato ML, Nahed BV, Wakimoto H, Curry WT, Iafrate AJ, Rivera MN, Frosch MP, Golub TR, Brastianos PK, Getz G, Patel AP, Monje M, Cahill DP, Rozenblatt-Rosen O, Louis DN, Bernstein BE, Regev A, Suva ML. Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science. 2017;355(6332). Epub 2017/04/01. doi: 10.1126/science.aai8478. PubMed PMID: 28360267.
    • Tirosh I, Venteicher AS, Hebert C, Escalante LE, Patel AP, Yizhak K, Fisher JM, Rodman C, Mount C, Filbin MG, Neftel C, Desai N, Nyman J, Izar B, Luo CC, Francis JM, Patel AA, Onozato ML, Riggi N, Livak KJ, Gennert D, Satija R, Nahed BV, Curry WT, Martuza RL, Mylvaganam R, Iafrate AJ, Frosch MP, Golub TR, Rivera MN, Getz G, Rozenblatt-Rosen O, Cahill DP, Monje M, Bernstein BE, Louis DN, Regev A, Suva ML. Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature. 2016;539(7628):309-13. Epub 2016/11/05. doi: 10.1038/nature20123.  PMC5465819.
    • Nigim F, Cavanaugh J, Patel AP, Curry WT, Jr., Esaki S, Kasper EM, Chi AS, Louis DN, Martuza RL, Rabkin SD, Wakimoto H. Targeting Hypoxia-Inducible Factor 1alpha in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment. Journal of Neuropathology and Experimental Neurology. 2015;74(7):710-22. Epub 2015/06/18. doi: 10.1097/NEN.0000000000000210. PMC4473779.
    • Riggi N, Knoechel B, Gillespie SM, Rheinbay E, Boulay G, Suva ML, Rossetti NE, Boonseng WE, Oksuz O, Cook EB, Formey A, Patel A, Gymrek M, Thapar V, Deshpande V, Ting DT, Hornicek FJ, Nielsen GP, Stamenkovic I, Aryee MJ, Bernstein BE, Rivera MN. EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma. Cancer Cell. 2014;26(5):668-81. Epub 2014/12/03. doi: 10.1016/j.ccell.2014.10.004. PMC4492343
    • Patel AP*, Tirosh I*, Trombetta JJ, Shalek AK, Gillespie SM, Wakimoto H, Cahill DP, Nahed BV, Curry WT, Martuza RL, Louis DN, Rozenblatt-Rosen O, Suva ML, Regev A, Bernstein BE. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014;344(6190):1396-401. Epub 2014/06/14. doi: 10.1126/science.1254257. PMC4123637.  *Co-first author
    • Walcott BP*, Patel AP*, Stapleton CJ, Trivedi RA, Young AMH, Ogilvy CS. Multiplexed protein profiling after aneurysmal subarachnoid hemorrhage: characterization of differential expression patterns in cerebral vasospasm. Journal of Clinical Neuroscience : Official journal of the Neurosurgical Society of Australasia. 2014;21(12):2135-9. Epub 2014/08/02. doi: 10.1016/j.jocn.2014.06.004. PMC4250356. *Co-first author
    • Suva ML, Rheinbay E, Gillespie SM, Patel AP, Wakimoto H, Rabkin SD, Riggi N, Chi AS, Cahill DP, Nahed BV, Curry WT, Martuza RL, Rivera MN, Rossetti N, Kasif S, Beik S, Kadri S, Tirosh I, Wortman I, Shalek AK, Rozenblatt-Rosen O, Regev A, Louis DN, Bernstein BE. Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. Cell. 2014;157(3):580-94. Epub 2014/04/15. doi: 10.1016/j.cell.2014.02.030. PMC4004670.
    • Rheinbay E, Suva ML, Gillespie SM, Wakimoto H, Patel AP, Shahid M, Oksuz O, Rabkin SD, Martuza RL, Rivera MN, Louis DN, Kasif S, Chis AS, Berstein BE.  An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma.  Cell Rep.  2013; 3:1567-1579.
    • Venteicher AS, Walcott BP, Sheth SA, Snuderl M, Patel AP, Curry WT, Nahed BV. Clinical features of brain metastasis from salivary gland tumors. Journal of Clinical Neuroscience: official journal of the Neurosurgical Society of Australasia. 2013;20(11):1533-7. PMC3749258.
    • Barnard Z, Wakimoto H, Zaupa C, Patel AP, Klehm J, Martuza RL, Rabkin SD, Curry WT, Jr. Expression of FMS-like tyrosine kinase 3 ligand by oncolytic herpes simplex virus type I prolongs survival in mice bearing established syngeneic intracranial malignant glioma. Neurosurgery. 2012;71(3):741-8; discussion 8. PMC3921689.
    • Wakimoto H, Mohapatra G, Kanai R, Curry WT, Jr., Yip S, Nitta M, Patel AP, Barnard ZR, Stemmer-Rachamimov AO, Louis DN, Martuza RL, Rabkin SD. Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells. Neuro-oncology. 2012;14(2):132-44. Epub 2011/11/10. doi: 10.1093/neuonc/nor195. PMC3266381.
    • Chan JL, Tang KC, Patel AP, Bonilla LM, Pierobon N, Ponzio NM, Rameshwar P.  Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma.  Blood.  2006; 107:4817-24.