Evidence for p53-Mediated Modulation of Neuronal Viability
Morrison, R.S.,Wenzel, H.J., Kinoshita, Y., Robbins,
C.A.,Donehower, L.A., Schwartzkroin, P.A. Loss of the p53 Tumor Suppressor
Gene Protects Neurons From Kainate Induced Cell Death. J. Neurosci.16:1337-1345,
1996.
Xiang, H., Hochman, D.W., Saya, H., Fujiwara, T., Schwartzkroin,
P.A. and Morrison, R.S.: Evidence for p53-Mediated Modulation of Neuronal
Viability. J. Neurosci., 16:6753-6765, 1996.
Photomicrographs of kainate-induced cell damage in
the hippocampus of p53 (+/+) (A,C,E) and (-/-) (B,D,F) mice. Kainate
administration produced seizures, which induced a significant degree of
neuronal damage in all pyramidal cell subfields of the hippocampus (except
in CA2) in wild-type mice (+/+). Figures A, C and E respectively use a
cresyl violet stain (CV), Fink-Heimer (FH) silver impregnation and TUNEL
labeling (T) (for DNA strand breaks) to illustrate the extensive cell
and terminal degeneration of pyramidal neurons in the CA3 and CA1 subregions
seven days following kainate administration. Except for a small amount
of damage in the CA3 region, p53 (-/-) mice show protection from kainate-induced
cell damage.
|
