In 2003 we had the following presentations (the research paper is also listed):
RPM 1/27/03 Jeremy Celver, Senior Fellow (Chavkin/McKnight lab) Xu et al, (2001) Direct Removal in the Mouse of a Floxed Neo Gene From a Three-loxP Conditional Knockout Allele by Two Novel Approaches. Genesis 30:1-6.
NIDA Training Grant Retreat 2/24/03 Current trainees each gave brief (15-20 min) presentations on their research to an audience of the mentors and other trainees. Cubaback, Lowe, Willis, Heusner; Kearn, Hoplight, Ferguson.
RPM 3/24/03 Claire Matson, Senior Fellow (Palmiter lab) Smith and Sclafani (2002) Saccharin as a sugar surrogate revisited. Appetite 38, 155-160.
RPM 4/28/03 Andrew Saxon (Director of the VA Addiction Treatment Clinic came to describe the studies using methadone, LAAM and buprenorphine for drug-relapse prevention and the NIDA-Clinical Trials Network Seattle Node] Krystal et al (2001) Naltrexone in the treatment of alcohol dependence. N Engl J Med 345: 1734-9. Johnson et al, (2000) A comparison of levomethadyl acetate, buprenorphine, and methadone for opioid dependence. N Engl J Med;343:1290-7. Goldstein and Volkow (2002) Drug Addiction and Its Underlying Neurobiological Basis: Neuroimaging Evidence for the Involvement of the Frontal Cortex. Am J Psychiatry 159:1642-1652.
RPM 5/19/03 Chris Kearn, Senior Fellow (Mackie lab).
RPM 6/23/03 Mike Weisenhaus, Grad Student (McKnight lab). Self et al, (1998) Involvement of cAMP-Dependent Protein Kinase in the Nucleus Accumbens in Cocaine Self-Administration and Relapse of Cocaine-Seeking Behavior. J Neurosci 18: 1848-1859.
RPM 9/15/03 Charles Chavkin, (Chavkin Lab). Jay P. McLaughlin, Monica Marton-Popovici, and Charles Chavkin (2003) Kappa Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses. Journal of Neuroscience, 23(13):5674-5683; Yavin Shaham, Uri Shalev, Lin Lu, Harriet de Wit, Jane Stewart (2003) The reinstatement model of drug relapse: history, methodology and major findings Psychopharmacology 168:3-20.
RPM 11/17/03 Nephi Stella. Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH. (2001) Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci U S A. 98(16):9371-6.
RPM 12/15/03 Richard Palmiter. Carelli RM, Wondolowski J. (2003) Selective encoding of cocaine versus natural rewards by nucleus accumbens neurons is not related to chronic drug exposure. J Neurosci. 23:11214-11223.
Other research Seminars and program events:
Research Seminar: Edwin R. Chapman (Univ Wisconsin), 2/24/03 "Dopamine Transporter: The Molecular Mechanism that Mediates Ca+2 Triggered Exocytosis."
Research Seminar: Andrea Guiffrida (Scripps), 3/25/03 "Endocannabinoid Modulation of Basal Ganglia Functions: Implications for Schizophrenia and Parkinson's Disease."
Research Seminar: Rob Malenka (Stanford), 4/29/03 "Synaptic Plasticity: The Brain's Response to Experience."
Research Seminar: Rick Huganir (Johns Hopkins), 4/30/03 "Receptors, Synapses and Memory."
Research Seminar: Julie Kauer (Brown), 5/21/03 "Synaptic plasticity in the midbrain dopaminergic reward system."
Research Seminar: Hugh Hemmings (Cornell), 10/28/03 "Presynaptic Targets for General Anesthetics."
Research Seminar: John Neumaier (Univ Wash), 12/4/03 "Sorting out Serotonin using viral gene transfer."