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Addiction: Mechanisms, Prevention, Treatment
Conjoint 556 - Autumn 2013
Meets on Thursday's, 3:00 - 5:00 PM, South Campus Center Room 224

9/26/13 Introduction to Addiction
(Chavkin, Pharmacology)
Hyman SE, Malenka RC, Nestler EJ. (2006) Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci. 2006;29:565-98.
 
Charbogne P, Kieffer BL, Befort K. (2013) 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology. 2013 Sep 10. [Epub ahead of print]
10/3/13 Dopamine hypothesis of addiction
(Phillips, Psychiatry & Pharmacology)
Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 85:5274-8.
 
Dackis CA, O'Brien CP (2001) Cocaine dependence: a disease of the brain's reward centers. J Subst Abuse Treat 21:111-7.
10/10/13 The Study of Genes, Environment and the Development of Addiction: goals/efforts/obstacles to date.
(Karl Hill, Social Work)
Brody GH, Beach SR, Hill KG, Howe GW, Prado G, Fullerton SM. (2013) Using Genetically Informed, Randomized Prevention Trials to Test Etiological Hypotheses About Child and Adolescent Drug Use and Psychopathology. Am J Public Health[Epub ahead of print]
 
Bevilacqua L, Goldman D. (2009) Genes and addictions. Clin Pharmacol Ther. 85(4):359-61.
 
Dick DM. (2011) Gene-environment interaction in psychological traits and disorders. Annu Rev Clin Psychol. 2011;7:383-409.
10/17/13 Etiology and prevention of alcohol use disorders in young adults.
(Mary Larimer, Psychiatry)
Hingson RW. (2010) Focus on: college drinking and related problems: magnitude and prevention of college drinking and related problems. Alcohol Res Health. 33(1):45-54.
 
Cronce JM, Larimer ME. (2011) Individual-focused approaches to the prevention of college student drinking./strong> Alcohol Res Health. 34(2):210-21.
10/24/13 Animal models of comorbid addiction & depression.
(John Neumaier, Psychiatry & Pharmacology)
George O, Le Moal M, Koob GF. (2012) Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiol Behav. 106(1):58-64.
 
Russo SJ, Nestler EJ. (2013) The brain reward circuitry in mood disorders Nat Rev Neurosci. Sep;14(9):609-25.
10/31/13 Harm reduction interventions for alcohol-use disorders.
(Susan Collins, Psychiatry)
Collins, E.S, Clifasefi, SL, Logan, DE, Samples, LS, Somers, JM, Marlatt, GA (2012) Current status, Historical Highlights and Basic Principles of Harm reduction. Chapter 1, Harm Reduction, eds. Marlatt, Larimer & Witkiewitz. Guilford Press.
 
Degenhardt L, Mathers B, Vickerman P, Rhodes T, Latkin C, Hickman M. (2010) Prevention of HIV infection for people who inject drugs: why individual, structural, and combination approaches are needed. Lancet. 376(9737):285-301.
11/7/13 Utilizing the research base for prevention science to change developmental environments.
(Rico Catalano, Social Work)
Catalano RF, Fagan, A. A., Gavin, L. E., Greenberg MT, Irwin CE, Ross DA, Shek DTL. (2012). Worldwide application of the prevention science research base in adolescent health. The Lancet. 379(9826), 1653-1664.
 
OConnell ME, Boat T, Warner KE. (2009). Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and Possibilities. Washington D.C. National Academies Press. Chapter 1 pp 15-27, Chapter 2 pp 35 -57, and Chapter 3 pp 59-69.
11/14/13 Pharmacologic treatments and medical consequences of addiction.
(Andrew Saxon, Psychiatry)
Litten RZ, Egli M, Heilig M, Cui C, Fertig JB, Ryan ML, Falk DE, Moss H, Huebner R, Noronha A. (2012) MaMedications development to treat alcohol dependence: a vision for the next decade. Addict Biol. 17(3):513-27
 
Rehm J, Room R, Graham K, Monteiro M, Gmel G, Sempos CT. (2003) The relationship of average volume of alcohol consumption and patterns of drinking to burden of disease: an overview. Addiction. 98(9):1209-28.
 
Kakko J, Svanborg KD, Kreek MJ, Heilig M. (2003) 1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial. Lancet. 361(9358):662-8.
11/21/13 Treatment approaches and matching
(Dennis Donovan, Psychiatry)
Witkiewitz K, Hartzler B, Donovan D. (2010) Matching motivation enhancement treatment to client motivation: re-examining the Project MATCH motivation matching hypothesis. Addiction. 105(8):1403-13.
 
Matching alcoholism treatments to client heterogeneity: Project MATCH three-year drinking outcomes. Alcohol Clin Exp Res. Sep;22(6):1300-11.
 
Martin GW, Rehm J. (2012) The effectiveness of psychosocial modalities in the treatment of alcohol problems in adults: a review of the evidence. Can J Psychiatry. 57(6):350-8.
 
Tober G. (2010) Commentary on Witkiewitz et al. (2010): evidence for matching - at last. Addiction. 105(8):1414-5.
11/28/13 Thanksgiving Holiday
 
12/5/13 Instructors: Wrap up discussion. Take a reasoned position on “Is Addiction a Curable disease? If so, how might a cure be envisioned? If not, what are the principal impediments?”
 
"Addiction Treatment With a Dark Side" Journalist: Deborah Sontag, NY Times article published 11/16/13 with readers' comments.
 
4-5PM Guests visiting from 1811 Eastlake "Wet-House" Alcohol Rehab Residence