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Opioid Systems Journal Club

Meets Fridays 9AM in D423 HSB
Course number: PHCOL 562

5/23/14 Selena Schattauer Mahalingam D, Keane M, Pirianov G, Mehmet H, Samali A, Szegezdi E. (2009) Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines. Br J Cancer. 100(9):1415-24.

5/16/14 Jamie Rose Levin Jamie Rose Kuhar, Andrea Bedini, Erica Melief, Jenny Chiu, and Charles Chavkin (In Preparation for JBC) Mu Opioid Receptor Stimulation Activates c-Jun N-Terminal Kinase 2 by Arrestin-Dependent and Independent Mechanisms

5/9/14 Josh Cohen Zhu CB, Lindler KM, Owens AW, Daws LC, Blakely RD, Hewlett WA. (2010) Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology. 35(13):2510-20.

5/2/14 Jonathan Ehrich Sorge RE, Martin LJ, Isbester KA, Sotocinal SG, Rosen S, Tuttle AH, Wieskopf JS, Acland EL, Dokova A, Kadoura B, Leger P, Mapplebeck JC, McPhail M, Delaney A, Wigerblad G, Schumann AP, Quinn T, Frasnelli J, Svensson CI, Sternberg WF, Mogil JS. (2014) Olfactory exposure to males, including men, causes stress and related analgesia in rodents. Nat Methods. 2014 Apr 28. doi: 10.1038/nmeth.2935. [Epub ahead of print]

3/21/14 Toni Hsu Yamaguchi T, Danjo T, Pastan I, Hikida T, Nakanishi S. (2013) Distinct roles of segregated transmission of the septo-habenular pathway in anxiety and fear. Neuron. 78(3):537-44.

3/14/14 Eedann McCord Practice pharmacology departmental rotation talk.

3/7/14 Jamie Rose Levin Practice annual progress report to Thesis Committee.

2/28/14 Selena Schattauer Wannemacher KM, Terskiy A, Bian S, Yadav PN, Li H, Howells RD. (2008) Purification and mass spectrometric analysis of the kappa opioid receptor. Brain Res. 1230:13-26.

2/14/14 Jonathan Ehrich Ehrich, JM et al. (in prep) The aversive properties of kappa opioid receptor agonists include p38alpha MAPK activation in dopaminergic neurons of the ventral tegmental area.

2/7/14 Andrea Bedini Fenalti G, Giguere PM, Katritch V, Huang XP, Thompson AA, Cherezov V, Roth BL, Stevens RC. (2014) Molecular control of δ-opioid receptor signalling. Nature. 506(7487):191-6.

1/12/14 Josh Cohen Mannangatti P, Arapulisamy O, Shippenberg TS, Ramamoorthy S, Jayanthi LD. (2011) Cocaine up-regulation of the norepinephrine transporter requires threonine 30 phosphorylation by p38 mitogen-activated protein kinase. J Biol Chem. 286(23):20239-50.

1/10/14 Charles Chavkin Corder G, Doolen S, Donahue RR, Winter MK, Jutras BL, He Y, Hu X, Wieskopf JS, Mogil JS, Storm DR, Wang ZJ, McCarson KE, Taylor BK. (2013) Constitutive μ-opioid receptor activity leads to long-term endogenous analgesia and dependence. Science. 341(6152):1394-9.

12/13/13 Jamie Rose Levin Kook S, Zhan X, Kaoud TS, Dalby KN, Gurevich VV, Gurevich EV. (2013) Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding. J Biol Chem. 288(52):37332-42.

11/22/13 Selena Schattauer Lane JR, Sexton PM, Christopoulos A. (2103) Bridging the gap: bitopic ligands of G-protein-coupled receptors. Trends Pharmacol Sci. 34(1):59-66.

11/15/13 Sabrina Kamran Molinari P, Vezzi V, Sbraccia M, Grò C, Riitano D, Ambrosio C, Casella I, Costa T. (2010) Morphine-like opiates selectively antagonize receptor-arrestin interactions. J Biol Chem. 285(17):12522-35

10/25/13 Joshua Cohen Cavalli V, Vilbois F, Corti M, Marcote MJ, Tamura K, Karin M, Arkinstall S, Gruenberg J. (2001) The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex. Mol Cell. 7(2):421-32.

10/17/13 Charles Chavkin Vardy E, Mosier PD, Frankowski KJ, Wu H, Katritch V, Westkaemper RB, Aube J, Stevens RC, Roth BL. (2013) Chemotype-Selective Modes of Action of kappa-Opioid Receptor Agonists. J Biol Chem. [Epub ahead of print]

White KL, Scopton AP, Rives ML, Bikbulatov RV, Polepally PR, Brown PJ, Kenakin T, Javitch JA, Zjawiony JK, Roth BL. (2013) Identification of Novel Functionally Selective Kappa Opioid Receptor Scaffolds. Mol Pharmacol. [Epub ahead of print]

10/11/13 Jamie Rose Levin Zhan X, Kaoud TS, Kook S, Dalby KN, Gurevich VV. (2013) JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinases. J Biol Chem. 288(40):28535-47.

9/27/13 Selena Schattauer Nonaka H, Fujishima SH, Uchinomiya SH, Ojida A, Hamachi I. (2010) Selective covalent labeling of tag-fused GPCR proteins on live cell surface with a synthetic probe for their functional analysis. J Am Chem Soc. 132(27):9301-9.

8/30/13 Joshua Cohen Gibson DG, Young L, Chuang RY, Venter JC, Hutchison CA 3rd, Smith HO. (2009) Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat Methods. 6(5):343-5.

8/9/13 Jamie Rose Levin Dykstra LA, Fischer BD, Balter RE, Henry FE, Schmidt KT, Miller LL. (2011) Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice. Behav Pharmacol. 22(5-6):540-7.

7/26/13 Pete Groblewski Graf EN, Wheeler RA, Baker DA, Ebben AL, Hill JE, McReynolds JR, Robble MA, Vranjkovic O, Wheeler DS, Mantsch JR, Gasser PJ. (2013) Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking. J Neurosci. 33(29):11800-10.

7/12/13 Andrea Bedini DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD. (2013) A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther. 344(3):708-17.

6/14/13 Selena Schattauer Rose M, Dütting E, Enz R. (2008) Band 4.1 proteins are expressed in the retina and interact with both isoforms of the metabotropic glutamate receptor type 8. J Neurochem. 2008 Jun 1;105(6):2375-87.

6/7/13 Charles Chavkin Wang Y, Barker K, Shi S, Diaz M, Mo B, Gutstein HB. (2012) Blockade of PDGFR-β activation eliminates morphine analgesic tolerance. Nat Med. 2012 Feb 19;18(3):385-7.

5/31/13 Pete Groblewski Chen BT, Yau HJ, Hatch C, Kusumoto-Yoshida I, Cho SL, Hopf FW, Bonci A. (2013) Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature. 496(7445):359-62.

5/17/13 Brooke Jarvie Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C. (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci. 28(2):407-14

5/10/13 Marta Soden Stuber GD, Klanker M, de Ridder B, Bowers MS, Joosten RN, Feenstra MG, Bonci A. (2008) Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. Science. 321(5896):1690-2.

4/5/13 Toni Hsu Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ. (2011) Habenular α5 nicotinic receptor subunit signalling controls nicotine intake. Nature. 471(7340):597-601.

3/22/13 Jonathan Ehrich Graziane NM, Polter AM, Briand LA, Pierce RC, Kauer JA. (2013) Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity. Neuron. 77(5):942-54.

3/1/13 Jessica Cao Milan-Lobo L, Gsandtner I, Gaubitzer E, Rünzler D, Buchmayer F, Köhler G, Bonci A, Freissmuth M, Sitte HH. (2009) Subtype-specific differences in corticotropin-releasing factor receptor complexes detected by fluorescence spectroscopy. Mol Pharmacol. 76(6):1196-210.

2/22/13 Pete Groblewski Piazza PV, Deroche-Gamonent V, Rouge-Pont F, Le Moal M. (2000) Vertical shifts in self-administration dose-response functions predict a drug-vulnerable phenotype predisposed to addiction. J Neurosci. 20:4226-4232.

2/15/13 Jamie Rose Levin Mittal N, Tan M, Egbuta O, Desai N, Crawford C, Xie CW, Evans C, Walwyn W. (2012) Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling. Neuropsychopharmacology. 37:1953-1962.

2/8/13 Marta Soden Niwa M, Jaaro-Peled H, Tankou S, Seshadri S, Hikida T, Matsumoto Y, Cascella NG, Kano S, Ozaki N, Nabeshima T, Sawa A. (2013) Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science. 339:335-339.

1/25/13 Toni Hsu Habenula cholinergic neurons corelease glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. In preparation for submission.

1/18/13 Selena Schattauer Mori T, Nomura M, Nagase H, Narita M, Suzuki T. (2009) Effects of a newly synthesized kappa-opioid receptor agonist, TRK-820, on the discriminative stimulus and rewarding effects of cocaine in rats. Psychopharmacology (Berl). 161:17-22.

1/10/13 Jonathan Ehrich Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel DJ, Nectow AR, Ekstrand M, Domingos A, Mazei-Robison MS, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH. (2013) Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature. 493:532-526.

11/30/12 Pete Groblewski Mihindou C, Guillem K, Navailles S, Vouillac C, Ahmed SH. (2012) Discriminative Inhibitory Control of Cocaine Seeking Involves the Prelimbic Prefrontal Cortex. Biol Psychiatry. [Epub ahead of print]

11/16/12 Selena Schattauer Prasad HC, Zhu CB, McCauley JL, Samuvel DJ, Ramamoorthy S, Shelton RC, Hewlett WA, Sutcliffe JS, Blakely RD. (2005) Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Proc Natl Acad Sci U S A. 102(32):11545-50.

11/9/12 Marta Soden Schizophrenia-associated mutation in KCNN3 evokes a dopamine neuron hyperphasic activation state (in preparation for publication)

11/2/12 Jamie Rose Levin Breitman M, Kook S, Gimenez LE, Lizama BN, Palazzo MC, Gurevich EV, Gurevich VV. (2012) Silent scaffolds: inhibition OF c-Jun N-terminal kinase 3 activity in cell by dominant-negative arrestin-3 mutant. J Biol Chem. 287(23):19653-64.

10/26/12 Josh Cohen Pisarchik A, Slominski A. (2004) Molecular and functional characterization of novel CRFR1 isoforms from the skin. Eur J Biochem. 271(13):2821-30.

10/19/12 Matt Soleiman Cachope R, Mateo Y, Mathur BN, Irving J, Wang HL, Morales M, Lovinger DM, Cheer JF. (2012) Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing. Cell Rep. 2(1):33-41.

10/12/12 Pete Groblewski Wee S, Vendruscolo LF Misra KKSchlosburg JEKoob GF (2012) A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence. 4(146):146ra110.

10/5/12 Charles Chavkin Li JG, Chen C, Huang P, Wang Y, Liu-Chen LY. (2012) 14-3-3zeta Protein Regulates Anterograde Transport of the Human ?-Opioid Receptor (hKOPR). J Biol Chem. 287(45):37778-92.

9/28/12 Jonathan Ehrich Maroteaux M, Mameli M. (2012) Cocaine evokes projection-specific synaptic plasticity of lateral habenula neurons. J Neurosci. 32(36):12641-6.

9/21/12 Selena Schattauer Schattauer SS, Miyatake M, Shankar H, Zietz C, Levin JR, Liu-Chen LY, Gurevich VV, Rieder MJ, Chavkin C. (2012) Ligand Directed Signaling Differences between Rodent and Human ?-Opioid Receptors. J Biol Chem. 287(50):41595-607.

8/24/12 Marta Soden Ngo-Anh TJ, Bloodgood BL, Lin M, Sabatini BL, Maylie J, Adelman JP. (2005) SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines. Nat Neurosci. 8(5):642-9.

8/10/12 Josh Cohen Waselus M, Nazzaro C, Valentino RJ, Van Bockstaele EJ. (2009) Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus. Biol Psychiatry. 66(1):76-83.

8/3/12 Jamie Rose Levin Giguère PMOestreich EADuncan JASiderovski DP. (2012) Regulation of the subcellular localization of the G-protein subunit regulator GPSM3 through direct association with 14-3-3 protein. J Biol Chem. 287(37):31270-9.

7/27/12 Abbie Schndler Mechanisms underlying the adverse consequences of stress: a role for the dynorphin/kappa opioid receptor system, p38alpha MAPK, and the serotonin transporter (Thesis defense)

6/21/12 Julia Lemos The impact of repeated stress on neuropeptidergic regulation of monoamine systems (Thesis defense)

6/15/12 Pete Groblewski Oleson EB, Richardson JM, Roberts DC. (2011) A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid. Psychopharmacology (Berl). 214(2):567-77.

6/8/12 Selena Schattauer Molecular Regulation of opioid receptor signaling (Thesis defense)

6/1/12 Jonathan Ehrich Shabel SJ, Proulx CD, Trias A, Murphy RT, Malinow R. (2012) Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin. Neuron. 74(3):475-81.

5/25/12 Charles Chavkin Urizar E, Yano H, Kolster R, Galés C, Lambert N, Javitch JA. (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nat Chem Biol. 2011 Jul 24;7(9):624-30.

5/11/12 Marta Soden Tan KR, Yvon C, Turiault M, Mirzabekov JJ, Doehner J, Labouèbe G, Deisseroth K, Tye KM, Lüscher C. (2012) GABA neurons of the VTA drive conditioned place aversion. Neuron. 73(6):1173-83.

5/4/12 Julia Lemos Kravitz AV, Tye LD, Kreitzer AC. (2012) Distinct roles for direct and indirect pathway striatal neurons in reinforcement. Nat Neurosci. Apr 29. doi: 10.1038/nn.3100. [Epub ahead of print]

4/27/12 Pete Groblewski Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Bao YP, Shi J, Epstein DH, Shaham Y, Lu L. (2012) A memory retrieval-extinction procedure to prevent drug craving and relapse. Science. 336(6078):241-5.

4/20/12 Jamie Rose Levin Xie WY, He Y, Yang YR, Li YF, Kang K, Xing BM, Wang Y. (2009) Disruption of Cdk5-associated phosphorylation of residue threonine-161 of the delta-opioid receptor: impaired receptor function and attenuated morphine antinociceptive tolerance. J Neurosci. 29(11):3551-64.

4/6/12 Rich Gustin Bach ME, Hawkins RD, Osman M, Kandel ER, Mayford M. (1995) Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency. Cell. 81(6):905-15.

3/30/12 Selena Schattauer Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. (2012) Structure of the human ?-opioid receptor in complex with JDTic. Nature. 485(7398):327-32.

3/16/12 Jonathan Ehrich Cohen JY, Haesler S, Vong L, Lowell BB, Uchida N. (2012) Neuron-type-specific signals for reward and punishment in the ventral tegmental area. Nature. 482(7383):85-8.

3/9/12 Julia Lemos Li C, Pleil KE, Stamatakis AM, Busan S, Vong L, Lowell BB, Stuber GD, Kash TL. (2012) Presynaptic inhibition of gamma-aminobutyric acid release in the bed nucleus of the stria terminalis by kappa opioid receptor signaling. Biol Psychiatry. 71(8):725-32.

3/2/12 Marta Soden Grube S, Gerchen MF, Adamcio B, Pardo LA, Martin S, Malzahn D, Papiol S, Begemann M, Ribbe K, Friedrichs H, Radyushkin KA, Müller M, Benseler F, Riggert J, Falkai P, Bickeböller H, Nave KA, Brose N, Stühmer W, Ehrenreich H. (2011) A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia. EMBO Mol Med 3(6):309-19.

2/24/12 Charles Chavkin Cruz FC, Quadros IM, Hogenelst K, Planeta CS, Miczek KA. (2011) Social defeat stress in rats: escalation of cocaine and "speedball" binge self-administration, but not heroin. Psychopharmacology (Berl). 215(1):165-75.

2/17/12 Jeff Smith Yan Y, Pushparaj A, Le Strat Y, Gamaleddin I, Barnes C, Justinova Z, Goldberg SR, Le Foll B. (2012) Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats. Neuropsychopharmacology. 37:685-96.

2/10/12 Jamie Rose Levin Terzi D, Cao Y, Agrimaki I, Martemyanov KA, Zachariou V. (2012) R7BP Modulates Opiate Analgesia and Tolerance but not Withdrawal. Neuropsychopharmacology. 37(4):1005-12.

2/3/12 Pete Groblewski Beckmann JS, Gipson CD, Marusich JA, Bardo MT. (2012) Escalation of cocaine intake with extended access in rats: dysregulated addiction or regulated acquisition? Psychopharmacology (Berl). 2012 Jan 17. [Epub ahead of print]

1/27/12 Dan Messinger Czéh B, Simon M, Schmelting B, Hiemke C, Fuchs E. (2006) Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment. Neuropsychopharmacology. 31(8):1616-26.

1/13/12 Priya Shankar Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW. (2008) Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal. 1(47):ra14.

1/13/12 Older Opioid JC Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW. (2008) Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal. 1(47):ra14.

See older Opioid Systems Journal Club events