The Cellular Neurophysiology Laboratory

at University of Washington

Seattle, Washington USA

IR image of living CA1 hippocampal pyramidal neurons visualized in the brain slice preparation. Note faint image of recording pipette on main apical dendrite (small arrow).

Recent publications

1. Poolos, N.P. and Johnston, D. (1999). Calcium-activated potassium conductances contribute to action potential repolarization at the soma but not the dendrites of hippocampal CA1 pyramidal neurons. J. Neurosci., 19:5205-12. (PDF Format)

2. Poolos, N.P., ed. (2001). Handbook of Differential Diagnosis in Neurology. Boston: Butterworth-Heinemann.

3. Poolos, N.P., Das, S., Clark, G.D., Lardizibal, D., Noebels, J.L., Wyllie, E., and Dobyns, W.B. (2002). Males with epilepsy, complete subcortical band heterotopia, and somatic mosaicism for the DCX gene. Neurology, 58:1559-1562.

4. Poolos, N.P., Migliore, M., and Johnston, D. (2002). Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nature Neurosci., 5:767-774. (PDF format)

5. Poolos, N.P. (2004). The yin and yang of the h-channel and its role in epilepsy. Epilepsy Curr.4:3-6. (PDF format)

6. Bernard, C., Anderson A., Becker A., Poolos, N.P., Beck, H., and Johnston, D. (2004). Acquired dendritic channelopathy in temporal lobe epilepsy. Science 305:532-535 (PDF format)

7. Poolos, N.P. (2005). The h-channel: a potential channelopathy in epilepsy? Epilepsy Behav., 7: 51-56.

8. Poolos, N.P., Bullis, J.B., and Roth, M.K. (2006). Modulation of h-channels in hippocampal pyramidal neurons by p38 MAPK. J. Neurosci., 26:7995-8003. Commentary in: Wynne, P. (2006). p38 mitogen-activated protein kinase: a novel modulator of hyperpolarization-activated cyclic nucleotide-gated channels and neuronal excitability. J. Neurosci. 26:11253-4.

9. Bullis, J.B., Jones, T.D., and Poolos, N.P. (2007). Reversed somatodendritic Ih gradient in a class of hippocampal neurons with pyramidal morphology, J. Physiol., 579:431-443. Commentary in: Colbert, C.M. (2007). A circuit within a circuit? J. Physiol. 579:289.

10.Jung, S., Jones, T.D., Lugo, Jr., J.N., Sheerin, A.H., Miller, J.W., D'ambrosio, R., Anderson, A.E., and Poolos, N.P. Progressive Dendritic HCN Channelopathy during Epileptogenesis in the Rat Pilocarpine Model of Epilepsy. J. Neurosci 27(47):13012–13021

 

Contact Information: Nicholas P. Poolos, MD, PhD | University of Washington Department of
Neurology and Regional Epilepsy Center | Box 359745 | 325 9th Ave | Seattle, WA 98104
206-897-5423 (office) |206-897-5424 (fax) | Nicholas Poolos, MD, PhD

Patient care issues and appointments: 206-744-3576

 

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