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Ob/Gyn Department
Division of Reproductive Endocrinology & Infertility
Donald K Clifton, PhD

Donald K Clifton, PhD
Professor

University of Washington
Department of Obstetrics & Gynecology
Box 356460
Seattle, WA 98195-6460

Main | Affiliations | Publications

Academic Office:
(206) 685-1854
Education:

• BS, Electrical Engineering
    (Oregon State University 1968)
• PhD, Neuroscience
    (Brain Research Institute, University of California, Los Angeles, 1979)

Research 
Interests:
Neuroendocrinology:
• Steroid feedback regulation of gonadotropin secretion
• Regulation of neuroendocrine functions by neuropeptides (GALP, galanin, NPY, POMC, CART, AgRP…)
• Nutritional and metabolic control of reproduction
• Image processing/analysis of in situ hybridization results
Professional 
Organizations:

• Endocrine Society
• Society for the Study of Reproduction
• Society for Neuroscience

Selected 
Publications:

Kauffman AS, Park JH, McPhie-Lalmansingh AA, Gottsch ML, Bodo C, Hohmann JG, Pavlova MN, Rohde AD, Clifton DK, Steiner RA, Rissman EF 2007 The kisspeptin receptor GPR54 is required for sexual differentiation of the brain and behavior. J Neurosci 27:8826-8835

Dungan HM, Gottsch ML, Zeng H, Gragerov A, Bergmann JE, Vassilatis DK, Clifton DK, Steiner RA 2007 The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone. J Neurosci 27:12088-12095

Kauffman AS, Gottsch ML, Roa J, Byquist AC, Crown A, Clifton DK, Hoffman GE, Steiner RA, Tena-Sempere M 2007 Sexual differentiation of Kiss1 gene expression in the brain of the rat. Endocrinology 148:1774-1783

Gottsch ML, Clifton DK, Steiner RA 2006 Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis. Mol Cell Endocrinol 254-255:91-96

Smith JT, Popa SM, Clifton DK, Hoffman GE, Steiner RA 2006 Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci 26:6687-6694

Smith JT, Acohido BV, Clifton DK, Steiner RA 2006 KiSS-1 neurones are direct targets for leptin in the ob/ob mouse. J Neuroendocrinol 18:298-303

Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, Herbison AE 2005 Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci 25:11349-11356

Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA 2005 Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146:3686-3692

Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA 2004 A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145:4073-4077

Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA 2004 Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 80:264-272


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