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Dorothy L Patton, PhD

Dorothy L Patton, PhD
Professor

University of Washington
Department of Obstetrics & Gynecology
Box 356460
Seattle, WA 98195-6460

Main | Affiliations | Honors | Publications

Academic Office:
(206) 543-5554
Education:

• BS, Biology
    (University of Puget Sound, 1971)
• MS, Biology
    (University of Puget Sound, 1973)
• PhD, Biological Structure
    (University of Washington, 1981)

Research 
Interests:
• Sexually transmitted infections (STI’s)—Chlamydia trachomatis,
   Trichomonas vaginalis
, SHIV
• Pathogenesis of PID and infertility
• Evaluating topical microbicides for vaginal/rectal application
• Topical microbicides: post-coital assessments
Current
Research :
Project 4 (LB/CV-N and RC101 Primate Testing) of CV-N Secreting Lactobacilli
  and Retrocyclin Microbicides

Lactobacilli as a Delivery Vehicle for Microbicides
Animal Models for Combination Microbicides
Improved Macaque Safety Model for Topical Microbicides:
  Post-coital Assessments

Topical Microbicide Safety and Efficacy Evaluation in Nonhuman Primates
Professional 
Organizations:

• American Sexually Transmitted Disease Association
• American Society of Microbiology
• Infectious Diseases Society of Obstetrics and Gynecology
• Pacific Coast Reproductive Society
• Phi Sigma Society

Honors:
• Squibb Award Recipient, Pacific Coast Reproductive Society, 1986, 1989
• Abbott Award Recipient, Pacific Coast Reproductive Society, 1988
• Tap Award Recipient, Pacific Coast Reproductive Society, 1996
• Wyeth-Ayerst Best Paper Award Recipient, Pacific Coast Reproductive Society, 1998
• Departmental Recognition Initiative Award, Univ Washington Dept of Ob/Gyn, 2000
Selected 
Publications:

Patton DL, Cosgrove Sweeney YT, Paul KJ. A summary of preclinical topical microbicide vaginal safety and Chlamydial efficacy evaluations in a pigtailed Macaque model. Sex Trans Dis. in press

Vincent KL, Bell BA, Rosenthal SL, Stanberry LR, Bourne N, Cosgrove-Sweeney YT, Patton DL, Montamedi M. Application of optical coherence tomography for monitoring changes in cervico vaginal epithelial morphology in Macaques: Potential for assessment of microbicide safety. Sex Trans Dis 35(3):269-75, 2008.

Patton DL, Cosgrove Sweeney YT, Balkus JE, Rohan LC, Moncla BJ, Parkiak MA, Hillier SL. Preclinical safety assessments of UC781 anti-HIV topical microbicide formulations. Antimicrobial Agents & Chemotherapy. 51(5):1608-1615, 2007.

Toth M, Patton DL, Esquenaiz B, Shevchuck M, Thaler H, Divon M. Association between Chlamydia trachomatis and abnormal uterine bleeding (AUB). Am J Reprod Immunol. 57(5):361-365, 2007.

Coleman J, Hitti J, Coombs R, Lockhart D, Mwachari C, Bukusi E, Gausman R, Jensen S, Patton D, Cohen C. Infectious correlates of HIV-1 shedding in the female upper and lower genital tracts. AIDS 21(6):755-759, 2007.

Patton DL, Cosgrove Sweeney YT, Balkus JE, Hillier SL. Vaginal and rectal topical microbicide development: Safety and efficacy of 1.0% Savvy™ (C31G) in the pigtailed macaque. Sex Trans Dis 33(11):691-695, 2006.

Patton DL, Cosgrove Sweeney YT, Agnew KJ, Balkus JE, Rabe LK, Hillier SL. Development of a non-human primate model for Trichomonas vaginalis infection. Sex Trans Dis 33(12):743-746, 2006.

Patton DL, Cosgrove Sweeney YT, McCarthy TD, Hillier SL. Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model. Antimicrob Agents Chemother 50(5):1696-1700, 2006.

Patton DL, Cosgrove Sweeney YT, Stamm WE. Significant reduction in the inflammatory response in the macaque model of chlamydial pelvic inflammatory disease with Azithromycin treatment. J Infect Dis 192:129-135, 2005.

Lichtenwalner AB, Patton DL, Van Voorhis WC, Cosgrove Sweeney YT, Kuo CC. Heat shock protein 60 is the major antigen which stimulates delayed-type hypersensitivity reaction in Macaque model of Chlamydia trachomatis salpingitis. Infect Immun 2004;72(2):1159–61.


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