SWISHER, MD, Elizabeth M
Professor
Adjunct Professor, Department of Medicine, Division of Medical Genetics
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Specialties:
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Gynecologic Oncology:
• Clinical trials for gynecologic malignancies • Application of biological modifiers to treatment of gynecologic malignancies • Genetics and risk reduction of hereditary cancers • Robotic surgery
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Licensure:
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• Washington, 1992
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Certification:
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• Obstetrics and Gynecology, 2001
• Gynecologic Oncology, 2003 |
| Joined UW Medicine: |
7/1/99
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Education:
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• MD degree
(University of California, San Diego, 1992) • Residency in Obstetrics and Gynecology (University of Washington, 1996) • Fellowship in Gynecologic Oncology (Washington University, 1999) • Women's Reproductive Health Research Career Development Program, Gynecologic Oncology (University of Washington, July 1999-October 2002) |
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Research Interests:
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• Molecular genetics of sporadic and familial ovarian cancer
• Development of novel diagnostic markers in ovarian cancer • Quality of life in patients with gynecologic cancers |
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Current Research:
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Function in BRCA1/2-Deficient Ovarian Carcinoma
• BRCA1/2 Restoration as a Predictor of Response in a |
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Professional Organizations:
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• American Congress of Obstetricians and Gynecologists
• American Association of Cancer Research • American Society of Clinical Oncology • Puget Sound Oncology Consortium |
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Honors:
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• Research Training Scholar Award, Women’s
Reproductive Health Research Career Development
Program, University of Washington, 1999–2002.
• Seattle's Best Doctors, 2010 and 2011
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Selected Publications:
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Norquist B, Wurz K, Pennil CC, Garcia R, Gross J, Sakai W, Karlan B, Swisher EM. Secondary Somatic Mutations Restoring BRCA1/2 Predict Chemotherapy Resistance in Hereditary Ovarian Carcinomas, J Clin Oncol 2011 Jun 27. [Epub ahead of print]. PMID:21709188
Press JZ, Wurz K, Norquist BM, Lee MK, Pennil C, Garcia R, Welcsh P, Goff BA, Swisher EM. Identification of a premalignant gene expression profile in tubal epithelium of BRCA1 mutation carriers. Neoplasia 2010 Dec; 12(12): 993-1002. PMID: 21170264 Walsh T, Lee MK, Casadei S, Thonton AM, Stray SM, Pennil C, Nord AS, Mandell JB, Swisher EM, King MC. Detection of inherited mutations for breast and ovarian cancer using genomic capture and massively parallel sequencing. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28): 12629-33. PMID: 20616022 Norquist B, Garcia R, Allison K, Jokinen C, Kernochan L, Pizzi C, Barrow B, Swisher E. The molecular pathegenesis of hereditary ovarian carcinoma: alterations in the tubal epithelium of women with BRCA1 and BRCA2 mutations. Cancer 2010 Nov 15; 116(22):5261-71. PMID: 20665887 Swisher EM, Gonzalez RM, Taniguchi, T, Garcia, RL, Walsh T, Goff BA, Welcsh P. Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas. Molecular Cancer 2009 July;8:48. PMID: 19602291 Swisher EM, Sakai W, Karlan BY, Wurz K, Urban N, Taniguchi T. Secondary BRCA1-mutated ovarian carcinomas with platinum resistance. Cancer Res 2008 April, 68(8):2581-6. PMID: 18413725 Sakai W, Swisher EM, Karlan BY, Agarwal MK, Higgins J, Friedman C, Villegas E, Jacquemont C, Farrugia DJ, Couch FJ, Urban N, Taniguchi T. Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers Nature, epub doi 10.1038/nature06633, Feb 8, 2008. Lamb JD, Garcia RL, Goff BA, Paley PP, Swisher EM. Predictors of occult neoplasia in women underging risk-reducing salpingo-oophorecotmy Am J Obstet Gynecol 2006 June;194(6):1702-9. PMID: 16731090 Walsh T, Casadei S, Coats KH, BS, Swisher E, Stray SM, Higgins J, Roach KC, Mandell J, Lee MK, Ciernikova S, Foretova L, Souck P, King MC. Spectrum of Mutations in BRCA1, BRCA2, CHEK2, and TP53 in Families at High Risk of Breast Cancer. JAMA 2006 March, 22;295(12):1379-88. PMID: 16551709 Swisher E, Wollan M, Mahtani S, Willner J, Garcia R, Goff B, King MD. Tumor-specific p53 sequences in blood and peritoneal fluid of women with epithelial ovarian cancer AM J Obstet Gynecol 2005 Sep;193(3):662-7. PMID:16150257
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