PATTON, PhD, Dorothy L
Professor
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Education:
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• BS, Biology
(University of Puget Sound, 1971) • MS, Biology (University of Puget Sound, 1973) • PhD, Biological Structure (University of Washington, 1981) |
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Research Interests:
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• Sexually transmitted infections (STI’s)—
Chlamydia trachomatis, Trichomonas vaginalis, Mycoplasma genitalium • Pathogenesis of PID and infertility • Evaluating topical microbicides for vaginal/rectal application • Topical microbicides: post-coital assessments |
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Current Research:
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Professional Organizations:
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• American Sexually Transmitted Disease Association
• American Society of Microbiology • Infectious Diseases Society of Obstetrics and Gynecology
• Pacific Coast Reproductive Society • Phi Sigma Society |
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Honors:
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• Squibb Award Recipient, Pacific Coast Reproductive
Society, 1986, 1989 • Abbott Award Recipient, Pacific Coast Reproductive Society, 1988 • Tap Award Recipient, Pacific Coast Reproductive Society, 1996 • Wyeth-Ayerst Best Paper Award Recipient, Pacific Coast Reproductive Society, 1998 • Departmental Recognition Initiative Award, University of Washington Dept of Ob/Gyn, 2000 |
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Selected Publications:
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Patton DL, Cosgrove Sweeney YT, Paul KJ. A summary of preclinical topical microbicide vaginal safety and Chlamydial efficacy evaluations in a pigtailed Macaque model. Sex Trans Dis 35(10):889-97, 2008.
PMID: 18607310
Patton DL, Cosgrove Sweeney YT, Paul KJ. A summary of preclinical topical microbicide rectal safety and efficacy evaluations in a pigtailed macaque model. Sex Trans Dis 36(6):350-56, 2009.
PMID: 19556929. PMCID: PMC2749653
Miyairi I, Ramsey KH, Patton DL. Duration of untreated Chamydia infection and factors associated with clearance: Review of animal studies. J Infect Dis. 201(S2):S96-S103, 2010
Sassi AB, Cost MR, Cole AL, Cole AM, Patton DL, Gupta P, Rohan LC. Formulation development of Retrocyclin-1 (RC-101) as an anti-HIV vaginal microbicide product. In Press. Antimicrob Agents Chemother. 55(5):2282-9, 2011. PMID 21321138. doi:10.1128/AAC.01190-10
Cole AM, Patton DL, Rohan LC, Cole AL, Cosgrove-Sweeney Y, Rogers NA, Sassi A, Tarwater P, Ruchia P, Lehrer RI, Waring AJ, Gupta P. The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. PloS ONE, 5(11):e15111.doi:10.137/journal.pone.0015111. 2010 PMID: 21124745
Sweeney YT, Cosgrove, Angeles RO, Cummings PK, Smith AD, Patton DL. Pigtailed Macaque model refinement: Topical microbicide safety in the presence of coitus. J Med Primatol. 2011 Mar 28. doi: 10.1111/j.1600-0684.2011.00478.x. PMID:21443565. PMCID: PMC3128681
Bell JD, Bergin IL, Harris LH, Chai D, Muller I, Mwenda J, Dalton VK, Vahratian AM, LeBar B, Zochowski M, Kiulia N, Aronoff DM, Patton DL. The effects of a single cervical inoculation of Chlamydia trachomatis on the femal reproductive tract of the Baboon (Papio Anubis). J Infect Dis
doi:10.1093/infdis/jir541
Henning T, Fakile Y, Phillips C, Sweeney E, Mitchell J, Patton DL, Sturdevant G, Caldwell HD, Secor WE, Papp J, Hendry RM, McNicholl J, Kersh E. Development of a pigtail Macaque model of sexually transmitted infection/HIV coinfection using Chamydia trachomatis, Trichomonas vaginalis and SHIV SF162P3.J Med Primatol, 40(2011) 214-223. doi:10.1111/j.1600-0684.2011.00488.x
Bell JD, Bergin IL, Schmidt K, Zochowski MK, Aronoff DM, Patton DL: Non-human primate models used to study pelvic inflammatory disease caused by Chlamydia trachomatis. Infect Dis in Obstet & Gynecol. 2011 (2011) 675360. Epub 2011 Aug 17Article ID 675360. doi:10.1155/2011/675360.
Patton DL: A guide for standardizing colposcopic observations for the evaluation of topical microbicide products in the Pigtailed Macaque model. J Med Primatol. In Press
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