Caroline Mitchell Dept web

Caroline M Mitchell, MD, MPH

Assistant Professor

Joined UW Medicine:


Clinical Focus:

Women's Health Care:
• Sexually transmitted diseases
• International women's health
• Immigrant health care


Washington, 2006


Obstetrics and Gynecology, 2008


• MD Degree
   (Harvard Medical School, 2002)
• Residency in Obstetrics and Gynecology
   (University of Washington, 2006)
• Masters in Public Health, Epidemiology
   (University of Washington, 2009)
• Women's Reproductive Health Research Career Development Scholar:
   HIV-1 and the Female Genital Tract
   (University of Washington, July 2006–March 2010)

Current Research:

• The Female Genital Innate Immune Response to Vaginal Microbiota (K08)
• Immune Response of the Upper Genital Tract Mucosa to Bacterial Colonization
• Development of New Tools to Examine Host-Microbe Interactions
   in the Reproductive Tract
• Modeling Intracellular and Extracellular Raltegravir (RAL) Pharmacokinetics
   in the Female Genital Tract and Blood after a Twice Daily 400 mg Dose
   over the Course of a Menstrual Cycle


• American Congress of Obstetricians and Gynecologists
• American Society for Microbiology
• Institute for Translational Health Sciences, University of Washington

Selected Publications:

Reed S, Laya M, Melville J, Ismail S, Mitchell C, Ackerman D. Prevalence of vitamin D deficiency and clinical associations among veiled East African women in Washington State. J Womens Health Mar 2007;16(2):206-13.

Mitchell C, Balkus J, Agnew K, Cohn S, Luque A, Lawler R, Coombs R, Hitti J.  Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of pro-inflammatory cytokines. AIDS Research and Human Retroviruses May 2008;24(5):667-71.

Mitchell C, Jennings C, Brambilla D, Aldrovandi G, Amedee AM, Beck I, Bremer J, Coombs R, Decker D, Fiscus S, Fitzgibbon J, Luzuriaga K, Moye J, Palumbo P, Reichelderfer P, Somasundaran M, Stevens W, Frenkel L for the Dried Blood Spot Working Group of the Infant Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) Network. HIV-1 DNA yield from dried blood spots is diminished after storage in a humid incubator at 37°C compared to -20°C. J Clin Microbiol Sept 2008;46(9):2945-9.

Fredricks D, Fiedler T, Thomas K, Mitchell C, Marrazzo J. Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. Journal of Clinical Microbiology Mar 2009;47(3):721-6.

Mitchell C, Hitti J, Agnew K, Fredricks D. Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteria. BMC Infectious Disease June 10, 2009;9(1):89.

Mitchell C, Balkus J, Agnew K, Lawler R, Hitti J. Changes in the vaginal microenvironment with metronidazole treatment for bacterial vaginosis in early pregnancy.  J Women's Health Nov 2009;18(11):1817-24.

Mitchell C, Moreira C, Fredricks D, Paul K, Caliendo A, Kurpewski J, Cu-Uvin S. Detection of fastidious vaginal bacteria in women with HIV infection and bacterial vaginosis. Infectious Diseases in Obstetrics & Gynecology 2009:236919. Epub 2009 Nov 12.

Mitchell C, Kraft K, Peterson D, Frenkel L. Cross-contamination during processing of dried blood spots used for rapid diagnosis of HIV-1 infection of infants is rare and avoidable. J Virological Methods Oct 28, 2009. [Epub ahead of print]

Srinivasan S, Liu C, Mitchell CM, Fiedler T, Thomas KK, Agnew KJ, Marrazzo JM, Fredricks DN. Temporal variations in human vaginal bacteria and relationship with bacterial vaginosis PloS One 2010; 5(4): e10197.

Mitchell C, Hitti J, Paul K, Agnew K, Cohn S, Luque A, Coombs R. Cervicovaginal shedding of HIV-1 is related to genital tract inflammation independent of changes in vaginal microbiota. AIDS Res Hum Retroviruses 2011 Jan;27(1):35–9. doi: 10.1089/aid.2010.0129. Epub 2010 Oct 7.

Appointments & Practice Locations

Harborview Women's Clinic (HMC)
325 Ninth Ave, Ground Floor, West Clinic
Seattle WA 98104-2499

Appointments:   206.744.3367


Columbia Health Center
4400 – 37th Ave South
Seattle, WA 98118

Appointments:   206.296.4650