Frasch Martin 1-6-16 copy

Martin G Frasch, MD, PhD

Research Assistant Professor

Joined UW Medicine:



• 09/95 to 06/01 MD Degree
   School of Medicine, Friedrich-Schiller University of Jena, Germany
• 07/01 to 10/04 Dr. med. (PhD equivalent)
   Institute for Pathophysiology, School of Medicine, Friedrich-Schiller University of Jena, Germany
• 07/03 to 06/06 Residency and Research, Hans-Berger Dept. of Neurology, School of Medicine, Friedrich-Schiller University of Jena, Germany
• 07/06 to 12/09 Post-doctoral fellowship, Lawson Health Research Institute, Dept. of Obstetrics and Gynaecology, University of Western Ontario, London, ON, Canada

Research Interests:

• Prevention of fetal brain and gut injury
• Non-invasive fetal health monitoring
• Fetal neuroscience
• Fetal neuroinflammation


• Society for Reproductive Investigation
• Society for Neuroscience
• American Physiological Society
• International Society for Developmental Origins of Health and Disease

Selected Pulications:

Cortes M, Cao M, Liu HL, Moore CS, Durosier LD, Burns P, Fecteau G, Desrochers A, Barreiro LB, Antel JP, Frasch MG. α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis. Sci Rep. 2017 Sep 6;7(1):10645. doi: 10.1038/s41598-017-09439-z.PMID: 28878260.

Li R, Frasch MG, Wu HT. Efficient Fetal-Maternal ECG Signal Separation from Two Channel Maternal Abdominal ECG via Diffusion-Based Channel Selection. Front Physiol. 2017 May 16;8:277. doi: 10.3389/fphys.2017.00277. eCollection 2017.

Harwood Kwan, Luca Garzoni, Hai Lun Liu, Mingju Cao, Andre Desrochers, Gilles Fecteau, Patrick Burns, Martin G Frasch. VNS in inflammation: systematic review of animal models and clinical studies. Bioelectronic Medicine 3: 1-6, 2016. Link.

M Cao, M Cortes, HL Liu, P Burns, C Moore, G Fecteau, A Desrochers, JP Antel, MG Frasch. Deriving primary fetal microglia and astrocyte cultures and establishing RNAseq pipeline to profile transcriptome in response to an in vitro challenge in near-term ovine fetus. J Neurosci Methods. 2017 Jan 30;276:23-32. doi: 10.1016/j.jneumeth.2016.11.008. Epub 2016 Nov 14.

Paul Anegroaie, Martin G Frasch, Sven Rupprecht, Thomas Müller, Harald Schubert, Otto W Witte, Matthias Schwab. Development of somatosensory evoked potentials in fetal sheep and effects of betamethasone. Acta Physiologica. 2016. In press.

MG Frasch, M Szynkaruk, AP Prout, K Nygard, R Veldhuizen, R Hammond, BS Richardson. Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway? J of Neuroinflammation. 2016 May 10;13(1):103.

Alex Xu, Brad Matushewski, Karen Nygard, Robert Hammond, Martin G Frasch and Bryan S Richardson. Brain Injury and Inflammatory Response to Umbilical Cord Occlusions is limited with Worsening Acidosis in Near-Term Ovine Fetus. Reprod Sci. 2016 Jul;23(7):858-70.

Christophe L Herry, Marina Cortes, Hau-Tieng Wu, Lucien D Durosier, Mingju Cao, Patrick Burns, André Desrochers, Gilles Fecteau, Andrew JE Seely and Martin G Frasch. Temporal patterns in sheep fetal heart rate variability correlate to systemic cytokine inflammatory response: a methodological exploration of monitoring potential using complex signals bioinformatics. PLoS One 2016 Apr 21;11(4): e0153515.

Brian W Nielsen, Elizabeth A Bonney, Bradley D Pearce, Leah Rae Donahue and Indra Neil Sarkar for the Preterm Birth International Collaborative (PREBIC). A Cross-Species Analysis of Animal Models for the Investigation of Preterm Birth Mechanisms. Reprod Sci. 2016 Apr;23(4):482-91.

L Garzoni, H Liu, LD Durosier, M Cao, C Herry, P Burns, G Fecteau, A Desrochers, N Patay, AJE Seely, C Faure and MG Frasch. Monitoring fetal intestinal inflammation using heart rate variability analysis. Pediatr Crit Care Med. 2016 Apr;17(4):e165-76.

Ross MG, Richardson, BS, Frasch MG. Value of base deficit. Am J Obstet Gynecol. 2016 Mar;214(3):416-7.

Vézina-Audette R, Frasch M, Burns P, Herry C, Chave E, Theoret C. Heart rate variability in relation to stress in the Asian elephant (Elephas maximus). Can Vet J. 2016 Mar;57(3):289-92.

Frasch MG, Richardson BS. US patent: "EEG Monitor of Fetal Health." December 2015. US 9,215,999.

Amaya K, Matushewski B, Durosier LD, Frasch MG, Richardson BS & Ross MG. (2015). Accelerated acidosis in response to variable fetal heart rate decelerations in chronically hypoxic ovine fetuses. American journal of obstetrics and gynecology.

Burns P, Liu HL, Kuthiala S, Fecteau G, Desrochers A, Durosier LD, Cao M, Frasch MG. Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings. J Vis Exp. 2015 Oct 25;(105):e52581. doi: 10.3791/52581. PMID: 26555084

Cao M, Cortes M, Moore CS, Leong SY, Durosier LD, Burns P, Fecteau G, Desrochers A, Auer RN, Barreiro LB, Antel JP & Frasch MG. (2015). Fetal microglial phenotype in vitro carries memory of prior in vivo exposure to inflammation. Frontiers in cellular neuroscience 9, 294.

Durosier LD, Herry CL, Cortes M, Cao M, Burns P, Desrochers A, Fecteau G, Seely AJ & Frasch MG. (2015). Does heart rate variability reflect the systemic inflammatory response in a fetal sheep model of lipopolysaccharide-induced sepsis? Physiological measurement 36, 2089-2102.

Frasch MG, Durosier LD, Gold N, Cao M, Matushewski B, Keenliside L, Louzoun Y, Ross MG & Richardson BS. (2015). Adaptive shut-down of EEG activity predicts critical acidemia in the near-term ovine fetus. Physiological reports 3.

Frasch MG, Frank B, Last M & Muller T. (2012). Time scales of autonomic information flow in near-term fetal sheep. Frontiers in physiology 3, 378.

Frasch MG, Keen AE, Gagnon R, Ross MG & Richardson BS. (2011). Monitoring fetal electrocortical activity during labour for predicting worsening acidemia: a prospective study in the ovine fetus near term. PloS one 6, e22100.

Frasch MG, Mansano RZ, McPhaul L, Gagnon R, Richardson BS & Ross MG. (2009a). Measures of acidosis with repetitive umbilical cord occlusions leading to fetal asphyxia in the near-term ovine fetus. American journal of obstetrics and gynecology 200, 200.e201-207.

Frasch MG, Muller T, Hoyer D, Weiss C, Schubert H & Schwab M. (2009b). Nonlinear properties of vagal and sympathetic modulations of heart rate variability in ovine fetus near term. American journal of physiology Regulatory, integrative and comparative physiology 296, R702-707.

Frasch MG, Muller T, Weiss C, Schwab K, Schubert H & Schwab M. (2009c). Heart rate variability analysis allows early asphyxia detection in ovine fetus. Reproductive sciences (Thousand Oaks, Calif) 16, 509-517.

Frasch MG, Muller T, Wicher C, Weiss C, Lohle M, Schwab K, Schubert H, Nathanielsz PW, Witte OW & Schwab M. (2007a). Fetal body weight and the development of the control of the cardiovascular system in fetal sheep. The Journal of physiology 579, 893-907.

Frasch MG, Walter B, Friedrich H, Hoyer D, Eiselt M & Bauer R. (2007b). Detecting the signature of reticulothalamocortical communication in cerebrocortical electrical activity. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 118, 1969-1979.

Frasch MG, Xu Y, Stampalija T, Durosier LD, Herry C, Wang X, Casati D, Seely AJ, Alfirevic Z, Gao X & Ferrazzi E. (2014). Correlating multidimensional fetal heart rate variability analysis with acid-base balance at birth. Physiological measurement 35, L1-12.

Garzoni L, Faure C & Frasch MG. (2013). Fetal cholinergic anti-inflammatory pathway and necrotizing enterocolitis: the brain-gut connection begins in utero. Frontiers in integrative neuroscience 7, 57.

Keen AE, Frasch MG, Sheehan MA, Matushewski B & Richardson BS. (2011). Maturational changes and effects of chronic hypoxemia on electrocortical activity in the ovine fetus. Brain research 1402, 38-45.

Lun Liu H, Garzoni L, Herry C, Durosier LD, Cao M, Burns P, Fecteau G, Desrochers A, Patey N, Seely AJ, Faure C, Frasch MG. Can Monitoring Fetal Intestinal Inflammation Using Heart Rate Variability Analysis Signal Incipient Necrotizing Enterocolitis of the Neona

Prout AP, Frasch MG, Veldhuizen R, Hammond R, Matushewski B & Richardson BS. (2012). The impact of intermittent umbilical cord occlusions on the inflammatory response in pre-term fetal sheep. PloS one 7, e39043.

Prout AP, Frasch MG, Veldhuizen RA, Hammond R, Ross MG & Richardson BS. (2010). Systemic and cerebral inflammatory response to umbilical cord occlusions with worsening acidosis in the ovine fetus. American journal of obstetrics and gynecology 202, 82.e81-89.

Ross MG, Amaya K, Richardson B & Frasch MG. (2013a). Association of atypical decelerations with acidemia. Obstetrics and gynecology 121, 1107-1108.

Ross MG, Jessie M, Amaya K, Matushewski B, Durosier LD, Frasch MG & Richardson BS. (2013b). Correlation of arterial fetal base deficit and lactate changes with severity of variable heart rate decelerations in the near-term ovine fetus. American journal of obstetrics and gynecology 208, 285.e281-286.

Wang Q, Gold N, Frasch MG, Huang H, Thiriet M & Wang X. (2015). Mathematical Model of Cardiovascular and Metabolic Responses to Umbilical Cord Occlusions in Fetal Sheep. Bulletin of mathematical biology 77, 2264-2293.

Xu A, Durosier LD, Ross MG, Hammond R, Richardson BS & Frasch MG. (2014). Adaptive brain shut-down counteracts neuroinflammation in the near-term ovine fetus. Frontiers in neurology 5, 110.

Please click here for the complete list of the PubMed publications.